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{{Infobox_gene}}
{{Infobox_gene}}
'''MAP/microtubule affinity-regulating kinase 4''' is an [[enzyme]] that in humans is encoded by the ''MARK4'' [[gene]].<ref name="pmid11326310">{{cite journal | vauthors = Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, Furukawa Y | title = Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis | journal = Neoplasia | volume = 3 | issue = 1 | pages = 4–9 | date = Apr 2001 | pmid = 11326310 | pmc = 1505019 | doi = 10.1038/sj/neo/7900132 }}</ref><ref name="pmid9108484">{{cite journal | vauthors = Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E | title = MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption | journal = Cell | volume = 89 | issue = 2 | pages = 297–308 | date = May 1997 | pmid = 9108484 | pmc =  | doi = 10.1016/S0092-8674(00)80208-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57787| accessdate = }}</ref>
'''MAP/microtubule affinity-regulating kinase 4''' is an [[enzyme]] that in humans is encoded by the ''MARK4'' [[gene]].<ref name="pmid11326310">{{cite journal | vauthors = Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, Furukawa Y | title = Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis | journal = Neoplasia | volume = 3 | issue = 1 | pages = 4–9 | date = Apr 2001 | pmid = 11326310 | pmc = 1505019 | doi = 10.1038/sj/neo/7900132 }}</ref><ref name="pmid9108484">{{cite journal | vauthors = Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E | title = MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption | journal = Cell | volume = 89 | issue = 2 | pages = 297–308 | date = April 1997 | pmid = 9108484 | pmc =  | doi = 10.1016/S0092-8674(00)80208-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57787| access-date = }}</ref> MARK4 belongs to the family of serine/threonine kinases that phosphorylate [[Microtubule-associated protein|microtubule-associated proteins]] (MAP) causing their detachment from microtubules.<ref>{{cite journal | vauthors = Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E | title = MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption | journal = Cell | volume = 89 | issue = 2 | pages = 297–308 | date = April 1997 | pmid = 9108484 }}</ref> Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.<ref>{{cite journal | vauthors = Naz F, Anjum F, Islam A, Ahmad F, Hassan MI | title = Microtubule affinity-regulating kinase 4: structure, function, and regulation | journal = Cell Biochemistry and Biophysics | volume = 67 | issue = 2 | pages = 485–99 | date = November 2013 | pmid = 23471664 | doi = 10.1007/s12013-013-9550-7 }}</ref>
 
There are four members of the MARK protein family, MARK1-4, which are highly conserved. MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in [[Alzheimer's disease]] and may contribute to the pathological phosphorylation of tau in this disease.


== Interactions ==
== Interactions ==


MARK4 has been shown to [[Protein-protein interaction|interact]] with [[USP9X]]<ref name=pmid18254724>{{cite journal | vauthors = Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR | title = Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains | journal = Biochem. J. | volume = 411 | issue = 2 | pages = 249–60 | date = Apr 2008 | pmid = 18254724 | doi = 10.1042/BJ20080067 }}</ref> and [[Ubiquitin C]].<ref name=pmid18254724/>
MARK4 has been shown to [[Protein-protein interaction|interact]] with [[USP9X]]<ref name=pmid18254724>{{cite journal | vauthors = Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR | title = Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains | journal = The Biochemical Journal | volume = 411 | issue = 2 | pages = 249–60 | date = April 2008 | pmid = 18254724 | doi = 10.1042/BJ20080067 }}</ref> and [[Ubiquitin C]].<ref name=pmid18254724/>


== References ==
== References ==
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== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | journal = DNA Res. | volume = 8 | issue = 2 | pages = 85–95 | year = 2001 | pmid = 11347906 | doi = 10.1093/dnares/8.2.85 }}
* {{cite journal | vauthors = Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 8 | issue = 2 | pages = 85–95 | date = April 2001 | pmid = 11347906 | doi = 10.1093/dnares/8.2.85 }}
* {{cite journal | vauthors = Beghini A, Magnani I, Roversi G, Piepoli T, Di Terlizzi S, Moroni RF, Pollo B, Fuhrman Conti AM, Cowell JK, Finocchiaro G, Larizza L | title = The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. | journal = Oncogene | volume = 22 | issue = 17 | pages = 2581–91 | year = 2003 | pmid = 12735302 | doi = 10.1038/sj.onc.1206336 }}
* {{cite journal | vauthors = Beghini A, Magnani I, Roversi G, Piepoli T, Di Terlizzi S, Moroni RF, Pollo B, Fuhrman Conti AM, Cowell JK, Finocchiaro G, Larizza L | title = The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines | journal = Oncogene | volume = 22 | issue = 17 | pages = 2581–91 | date = May 2003 | pmid = 12735302 | doi = 10.1038/sj.onc.1206336 }}
* {{cite journal | vauthors = Trinczek B, Brajenovic M, Ebneth A, Drewes G | title = MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. | journal = J. Biol. Chem. | volume = 279 | issue = 7 | pages = 5915–23 | year = 2004 | pmid = 14594945 | doi = 10.1074/jbc.M304528200 }}
* {{cite journal | vauthors = Trinczek B, Brajenovic M, Ebneth A, Drewes G | title = MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5915–23 | date = February 2004 | pmid = 14594945 | doi = 10.1074/jbc.M304528200 }}
* {{cite journal | vauthors = Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G | title = Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. | journal = J. Biol. Chem. | volume = 279 | issue = 13 | pages = 12804–11 | year = 2004 | pmid = 14676191 | doi = 10.1074/jbc.M312171200 }}
* {{cite journal | vauthors = Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G | title = Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network | journal = The Journal of Biological Chemistry | volume = 279 | issue = 13 | pages = 12804–11 | date = March 2004 | pmid = 14676191 | doi = 10.1074/jbc.M312171200 }}
* {{cite journal | vauthors = Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grünewald S, Kuner R, Weber D, Krüger C, Klaussner B, Götz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M | title = Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4. | journal = J. Neurochem. | volume = 88 | issue = 5 | pages = 1114–26 | year = 2004 | pmid = 15009667 | doi = 10.1046/j.1471-4159.2003.02228.x }}
* {{cite journal | vauthors = Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grünewald S, Kuner R, Weber D, Krüger C, Klaussner B, Götz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M | title = Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4 | journal = Journal of Neurochemistry | volume = 88 | issue = 5 | pages = 1114–26 | date = March 2004 | pmid = 15009667 | doi = 10.1046/j.1471-4159.2003.02228.x }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | authorlink30 = Huda Zoghbi }}
* {{cite journal | vauthors = Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H | title = Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. | journal = Mol. Cell. Proteomics | volume = 6 | issue = 3 | pages = 537–47 | year = 2007 | pmid = 17192257 | doi = 10.1074/mcp.T600062-MCP200 }}
* {{cite journal | vauthors = Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H | title = Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 6 | issue = 3 | pages = 537–47 | date = March 2007 | pmid = 17192257 | doi = 10.1074/mcp.T600062-MCP200 }}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]
[[Category:EC 2.7.11]]


{{gene-19-stub}}
{{gene-19-stub}}

Latest revision as of 18:34, 25 November 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene.[1][2][3] MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules.[4] Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.[5]

There are four members of the MARK protein family, MARK1-4, which are highly conserved. MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in Alzheimer's disease and may contribute to the pathological phosphorylation of tau in this disease.

Interactions

MARK4 has been shown to interact with USP9X[6] and Ubiquitin C.[6]

References

  1. ↑ Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, Furukawa Y (Apr 2001). "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis". Neoplasia. 3 (1): 4–9. doi:10.1038/sj/neo/7900132. PMC 1505019. PMID 11326310.
  2. ↑ Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484.
  3. ↑ "Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4".
  4. ↑ Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. PMID 9108484.
  5. ↑ Naz F, Anjum F, Islam A, Ahmad F, Hassan MI (November 2013). "Microtubule affinity-regulating kinase 4: structure, function, and regulation". Cell Biochemistry and Biophysics. 67 (2): 485–99. doi:10.1007/s12013-013-9550-7. PMID 23471664.
  6. ↑ 6.0 6.1 Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (April 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains". The Biochemical Journal. 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724.

Further reading

  • Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Beghini A, Magnani I, Roversi G, Piepoli T, Di Terlizzi S, Moroni RF, Pollo B, Fuhrman Conti AM, Cowell JK, Finocchiaro G, Larizza L (May 2003). "The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines". Oncogene. 22 (17): 2581–91. doi:10.1038/sj.onc.1206336. PMID 12735302.
  • Trinczek B, Brajenovic M, Ebneth A, Drewes G (February 2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". The Journal of Biological Chemistry. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
  • Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (March 2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". The Journal of Biological Chemistry. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
  • Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grünewald S, Kuner R, Weber D, Krüger C, Klaussner B, Götz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M (March 2004). "Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4". Journal of Neurochemistry. 88 (5): 1114–26. doi:10.1046/j.1471-4159.2003.02228.x. PMID 15009667.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (March 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
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