Lysyl hydroxylase
| procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | |
|---|---|
| Identifiers | |
| Symbol | PLOD1 |
| Alt. symbols | LLH, PLOD |
| Entrez | 5351 |
| HUGO | 9081 |
| OMIM | 153454 |
| RefSeq | NM_000302 |
| UniProt | Q02809 |
| Other data | |
| EC number | 1.14.11.4 |
| Locus | Chr. 1 p36.3-36.2 |
| procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | |
|---|---|
| Identifiers | |
| Symbol | PLOD2 |
| Entrez | 5352 |
| HUGO | 9082 |
| OMIM | 601865 |
| RefSeq | NM_000935 |
| UniProt | O00469 |
| Other data | |
| Locus | Chr. 3 q24 |
Overview
Lysyl hydroxylase (or procollagen-lysine 5-dioxygenase) is an oxygenase enzyme which catalyzes the hydroxylation of lysine to hydroxylysine. This reaction is involved in the formation and stabilization of collagen.
It requires vitamin C as a cofactor.
Pathology
A deficiency is associated with Ehlers-Danlos syndrome.
External links
- Lysyl+Hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
- Template:Dorlands