Prolyl hydroxylase

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Prolyl hydroxylase (or procollagen-proline dioxygenase) is an enzyme involved in the production of collagen, acting to hydroxylate proline to hydroxyproline.

It requires vitamin C as a cofactor.

Reaction: Proline + α-ketoglutarate + O2 + Fe2+ → 4-hydroxyproline + Fe4+ + CO2 + succinate

The process requires ascorbic acid which provides Fe2+as a reductant to provide two electrons.

It is classified under EC

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