Lymphoplasmacytic lymphoma MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

There are no specific MRI findings associated with Waldenström macroglobulinemia.

MRI

There are no specific MRI findings associated with Waldenström macroglobulinemia. However, MRI of the brain, spinal cord and orbits is important when assessing for hyperviscosity in the presence of high IgM paraprotein in the blood especially important when diagnosing Bing-Neel syndrome.[1][2][3]

Axial T1-weighted (TR 700, TE 30) 3mm noncontrast sections through the petrous bone. Arrows indicate T1 shortening within the labyrinth.Source: Shibata DK. et al.
Coronal T1-weighted (TR 600, TE 30) 3mm noncontrast sections through the inner ear. Arrows indicate hemorrhage within the labyrinth.Source: Shibata DK. et al.
MRI brain coronal view shows diffuse meningeal enhancement.Source: Halperin D. et al, Whipps Cross Hospital, London E11 1NR, UK.

References

  1. O'Neil DS, Francescone MA, Khan K, Bachir A, O'Connor OA, Sawas A (2018). "A Case of Bing-Neel Syndrome Successfully Treated with Ibrutinib". Case Rep Hematol. 2018: 8573105. doi:10.1155/2018/8573105. PMC 6136466. PMID 30228918.
  2. Minnema MC, Kimby E, D'Sa S, Fornecker LM, Poulain S, Snijders TJ; et al. (2017). "Guideline for the diagnosis, treatment and response criteria for Bing-Neel syndrome". Haematologica. 102 (1): 43–51. doi:10.3324/haematol.2016.147728. PMC 5210231. PMID 27758817.
  3. Tallant A, Selig D, Wanko SO, Roswarski J (2018). "First-line ibrutinib for Bing-Neel syndrome". BMJ Case Rep. 2018. doi:10.1136/bcr-2018-226102. PMID 30279255.

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