Lisch nodule pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Swathi Venkatesan, M.B.B.S.[2]
Pathophysiology of Lisch Nodule
- A hamartoma is defined as a benign tumor or nodular growth that is composed of proliferating mature histologically normal cells that normally reside at the affected tissue
- In ophthalmic jargon, iris hamartomas traditionally refer to Lisch nodules which are encountered in patients with neurofibromatosis type 1 (NF1).
- Histopathologically, Lisch nodules are composed of melanocytes and spindle cells, usually concentrated on the superficial layers of the iris stroma. [1]
- The spindle cells are larger than the normal iris melanocytes.
- Immunohistochemical studies show positive reaction against vimentin, smooth muscle actin and neuron specific enolase.
References
- ↑ Kiratli, H (2011). "Head and Neck: Iris Hamartomas". Atlas of Genetics and Cytogenetics in Oncology and Haematology (1). doi:10.4267/2042/44673. ISSN 1768-3262.