Lisch nodule epidemiology and demographics: Difference between revisions
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*Lisch nodules are predominantly visible in children usually after the age of six years.<ref name="MaharajSingh,2014">{{cite journal|last1=Maharaj|first1=A|last2=Singh,|first2=VRS|last3=Lalchan|first3=SA|title=Lisch and the Importance of His Nodules|journal=West Indian Medical Journal|year=2014|issn=00433144|doi=10.7727/wimj.2013.323}}</ref> | *Lisch nodules are predominantly visible in children usually after the age of six years.<ref name="MaharajSingh,2014">{{cite journal|last1=Maharaj|first1=A|last2=Singh,|first2=VRS|last3=Lalchan|first3=SA|title=Lisch and the Importance of His Nodules|journal=West Indian Medical Journal|year=2014|issn=00433144|doi=10.7727/wimj.2013.323}}</ref> | ||
*Lisch Nodule incidence in NF1 increases with age and their prevalence raises by about 10% per year of life, up to age 9. | *Lisch Nodule incidence in NF1 increases with age and their prevalence raises by about 10% per year of life, up to age 9. | ||
*Lisch nodules are found in 93% of adults with NF-1 but have not been described in NF-2. | *Lisch nodules are found in 93% of adults with NF-1 but have not been described in NF-2.<ref name="Charles1989">{{cite journal|last1=Charles|first1=S. J.|title=Lisch Nodules in Neurofibromatosis Type 2|journal=Archives of Ophthalmology|volume=107|issue=11|year=1989|pages=1571|issn=0003-9950|doi=10.1001/archopht.1989.01070020649012}}</ref> | ||
*Lisch Nodules may be found in a very limited number of individuals without NF.<ref name="GreeneMale1987">{{cite journal|last1=Greene|first1=Carol L|last2=Male|first2=Wendy S|last3=Coleman|first3=Shelley H|last4=Ohrliok|first4=Martin E|last5=Gordon|first5=Robert A|title=LISCH NODULES IN AN UNSELECTED POPULATION: PREVALENCE AND USEFULNESS AS INDICATION OF NEUROFIBROMATOSIS|journal=Pediatric Research|volume=21|issue=4|year=1987|pages=227A–227A|issn=0031-3998|doi=10.1203/00006450-198704010-00368}}</ref> | *Lisch Nodules may be found in a very limited number of individuals without NF.<ref name="GreeneMale1987">{{cite journal|last1=Greene|first1=Carol L|last2=Male|first2=Wendy S|last3=Coleman|first3=Shelley H|last4=Ohrliok|first4=Martin E|last5=Gordon|first5=Robert A|title=LISCH NODULES IN AN UNSELECTED POPULATION: PREVALENCE AND USEFULNESS AS INDICATION OF NEUROFIBROMATOSIS|journal=Pediatric Research|volume=21|issue=4|year=1987|pages=227A–227A|issn=0031-3998|doi=10.1203/00006450-198704010-00368}}</ref> | ||
Revision as of 14:29, 12 June 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Swathi Venkatesan, M.B.B.S.[2]
Epidemiology & Demographics
- NF1 is an autosomal dominant genetic disorder with an incidence of approximately 1 in 2600 to 3000 individuals.
- Approximately one-half of the cases are familial (inherited)
- The remainder are the result of de novo (sporadic) mutations.
- The de novo mutations occur primarily in paternally derived chromosomes, and the likelihood of de novo NF1 increases with advanced paternal age
- Lisch nodules are predominantly visible in children usually after the age of six years.[1]
- Lisch Nodule incidence in NF1 increases with age and their prevalence raises by about 10% per year of life, up to age 9.
- Lisch nodules are found in 93% of adults with NF-1 but have not been described in NF-2.[2]
- Lisch Nodules may be found in a very limited number of individuals without NF.[3]
References
- ↑ Maharaj, A; Singh,, VRS; Lalchan, SA (2014). "Lisch and the Importance of His Nodules". West Indian Medical Journal. doi:10.7727/wimj.2013.323. ISSN 0043-3144.
- ↑ Charles, S. J. (1989). "Lisch Nodules in Neurofibromatosis Type 2". Archives of Ophthalmology. 107 (11): 1571. doi:10.1001/archopht.1989.01070020649012. ISSN 0003-9950.
- ↑ Greene, Carol L; Male, Wendy S; Coleman, Shelley H; Ohrliok, Martin E; Gordon, Robert A (1987). "LISCH NODULES IN AN UNSELECTED POPULATION: PREVALENCE AND USEFULNESS AS INDICATION OF NEUROFIBROMATOSIS". Pediatric Research. 21 (4): 227A–227A. doi:10.1203/00006450-198704010-00368. ISSN 0031-3998.