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==Classification==
==Classification==
===Anicteric leptospirosis===
===Anicteric leptospirosis===
* More common but serious illness is uncommon<ref>{{cite web |url=http://www.ncdc.gov.in/writereaddata/mainlinkfile/File558.pdf |title= Leptospirosis |last=prasad |first=jagadeesh |date= |website= |publisher= |access-date= |quote=}}</ref>
* More common but serious [[illness]] is uncommon<ref>{{cite web |url=http://www.ncdc.gov.in/writereaddata/mainlinkfile/File558.pdf |title= Leptospirosis |last=prasad |first=jagadeesh |date= |website= |publisher= |access-date= |quote=}}</ref>
* Most of cases present either subclinical or of very mild severity.
* Most of cases present either subclinical or of very mild severity.
* Few cases present with a febrile illness of sudden onset.
* Few cases present with a [[febrile]] illness of sudden onset.
* Other symptoms include [[chills]], [[headache]] (severe with retro-orbital pain and [[photophobia]]), [[myalgia]], [[abdominal pain]], conjunctival suffusion, and [[skin rash]] (transient and last < 24 hours)
* Other symptoms include [[chills]], [[headache]] (severe with retro-orbital [[pain]] and [[photophobia]]), [[myalgia]], [[abdominal pain]], [[conjunctival]] suffusion, and [[skin rash]] (transient and last < 24 hours)
* May progress to [[aseptic meningitis]] in ≤ 25% of patients and more common in younger age group than the patients with icteric leptospirosis.
* May progress to [[aseptic meningitis]] in ≤ 25% of patients and more common in younger age group than the patients with icteric leptospirosis.
* Mortality is very less when compared to icteric leptospirosis
* Mortality is very less when compared to icteric leptospirosis
===Icteric leptospirosis===
===Icteric leptospirosis===
* Rapidly progressive and severe form of leptospirosis ([[Weil's disease]])
* Rapidly progressive and severe form of leptospirosis ([[Weil's disease]])
* In the severe form of leptospirosis [[renal failure]], [[hepatic failure]] and pulmonary haemorrhage can occur and associate with Icterohaemorrhagiae.<ref name="pmid11692294">{{cite journal| author=Katz AR, Ansdell VE, Effler PV, Middleton CR, Sasaki DM| title=Assessment of the clinical presentation and treatment of 353 cases of laboratory-confirmed leptospirosis in Hawaii, 1974-1998. | journal=Clin Infect Dis | year= 2001 | volume= 33 | issue= 11 | pages= 1834-41 | pmid=11692294 | doi=10.1086/324084 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11692294  }} </ref>
* In the severe form of leptospirosis [[renal failure]], [[hepatic failure]] and [[pulmonary]] [[hemorrhage]] can occur and associate with Icterohemorrhagiae.<ref name="pmid11692294">{{cite journal| author=Katz AR, Ansdell VE, Effler PV, Middleton CR, Sasaki DM| title=Assessment of the clinical presentation and treatment of 353 cases of laboratory-confirmed leptospirosis in Hawaii, 1974-1998. | journal=Clin Infect Dis | year= 2001 | volume= 33 | issue= 11 | pages= 1834-41 | pmid=11692294 | doi=10.1086/324084 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11692294  }} </ref>
* Less common form of leptospirosis with incidence of 5%-10%.
* Less common form of leptospirosis with incidence of 5%-10%.
* [[Jaundice]] is not associate with hepatocellular injury, eventually [[Liver function tests|LFT]] returns to normal after recovery.
* [[Jaundice]] is not associate with hepatocellular injury, eventually [[Liver function tests|LFT]] returns to normal after recovery.

Revision as of 15:49, 3 April 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [2]

Overview

Leptospirosis is classified into anicteric and icteric form of leptospirosis based on the clinical presentation.

Classification

Anicteric leptospirosis

  • More common but serious illness is uncommon[1]
  • Most of cases present either subclinical or of very mild severity.
  • Few cases present with a febrile illness of sudden onset.
  • Other symptoms include chills, headache (severe with retro-orbital pain and photophobia), myalgia, abdominal pain, conjunctival suffusion, and skin rash (transient and last < 24 hours)
  • May progress to aseptic meningitis in ≤ 25% of patients and more common in younger age group than the patients with icteric leptospirosis.
  • Mortality is very less when compared to icteric leptospirosis

Icteric leptospirosis

  • Rapidly progressive and severe form of leptospirosis (Weil's disease)
  • In the severe form of leptospirosis renal failure, hepatic failure and pulmonary hemorrhage can occur and associate with Icterohemorrhagiae.[2]
  • Less common form of leptospirosis with incidence of 5%-10%.
  • Jaundice is not associate with hepatocellular injury, eventually LFT returns to normal after recovery.
  • High mortality rate with a range of 5%-15%.

References

  1. prasad, jagadeesh. "Leptospirosis" (PDF).
  2. Katz AR, Ansdell VE, Effler PV, Middleton CR, Sasaki DM (2001). "Assessment of the clinical presentation and treatment of 353 cases of laboratory-confirmed leptospirosis in Hawaii, 1974-1998". Clin Infect Dis. 33 (11): 1834–41. doi:10.1086/324084. PMID 11692294.