Leiomyosarcoma differential diagnosis: Difference between revisions

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Revision as of 08:18, 11 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Leiomyosarcoma must be differentiated from Peptic ulcer, Stomach cancer, Uterine cancer.

Differentiating Leiomyosarcoma from other Diseases

The table below summarizes the findings that differentiate Leiomyosarcoma from other conditions that may cause similar signs and symptoms.[1][2][3]

Disease Clinical Features Physical Examination Diagnosis
Gastric cancer Abdominal pain, Weight loss, Heartburn, Belching,Nausea,Vomiting,Weight loss,Loss of Appetite,Dysphagia,Hemetemesis,Melena Pallor,Jaundice,Acanthosis Nigrans,Leasr-Trelat signs,Left supraclavicular Lypmph adenopathy,Abdominal mass and distension,Splenomegaly,Ascites,Hepattomegaly. Esophagogastroduodenoscopy
Endometrial Cancer Abnormal Vaginal bleeding,Post coital bleeding,Fatigue,weight loss,Pelvic pain and dysparunia Tachycardia,Tachypnea,Pallor,Jaundice,Vaginal bleeding, Enlarged uterus,Pedal Edema,Hepatomegaly,Lymphadenopathy,Decreased breath sounds(depending upon the staging of the cancer) CBC,LFT,CA-125,CA,PFT,xray chest,CT,MRI,Ultrasound, Endometrial Curettage,D and C,Endometrial Biopsy and Tru test.
Peptic Ulcer Disease Episodic epigastric pain,fever,melena,hematemesis Hypotension if perforation,Abdominal guarding and rigidity,normal bowel sounds Ascites fluid analysis for LDH,glucose,and protein,chest xray if perforation,Upper GI Endoscopy,Serum gastrin level,Secretin stimulation test,Biopsy
Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging Histopathology
Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Lab 1 Lab 2 Lab 3 Imaging 1 Imaging 2 Imaging 3
Peptic Ulcer Disease Episodic Epigastric pain Melena Hematemesis Epigastric tenderness Abdominal guarding and rigidity if perforated Normal Bowel Sounds CBC Suggestive of Anemia Serum Gastrin Level or Secretin stimulation test to rule out Zollinger Ellison syndrome Urea breath test or Stool antigen done for Helicobacter pylori Chest xray suggestive of pneumoperitoneum if perforated CT scan suggestive of pneumoperitoneumif perforated peptic ulcer - Upper GI Endoscopy
Gastric Adenocarcinoma Abdominal pain Dysphagia Hematemesis or Melena Abdominal mass/Distension Pallor Left supraclavicular lyphadenopathy CBC suggestive of anemia Esophagogastrduodenoscopy
Endometrial Cancer Abnormal Vaginal bleeding or post coital bleeding Pelvic pain Dysparunia Vaginal Bleeding Enlarged uterus Lymphadenopathy Biopsy under hysteroscopic guidance
Diseases Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Lab 1 Lab 2 Lab 3 Imaging 1 Imaging 2 Imaging 3 Histopathology Gold standard Additional findings
Differential Diagnosis 4
Differential Diagnosis 5
Differential Diagnosis 6

References

  1. Cotton PB, Shorvon PJ (1984) Analysis of endoscopy and radiography in the diagnosis, follow-up and treatment of peptic ulcer disease. Clin Gastroenterol 13 (2):383-403. PMID: 6378443
  2. Wanebo HJ, Kennedy BJ, Chmiel J, Steele G, Winchester D, Osteen R (1993) Cancer of the stomach. A patient care study by the American College of Surgeons. Ann Surg 218 (5):583-92. PMID: 8239772
  3. Kimura T, Kamiura S, Yamamoto T, Seino-Noda H, Ohira H, Saji F (2004) Abnormal uterine bleeding and prognosis of endometrial cancer. Int J Gynaecol Obstet 85 (2):145-50. DOI:10.1016/j.ijgo.2003.12.001 PMID: 15099776


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