Langerhans cell histiocytosis classification: Difference between revisions
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==Overview== | ==Overview== | ||
Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis. | Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.<ref name="patho">Langerhans cell histiocytosis. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis#cite_note-10 Accessed on February, 3 2016</ref> | ||
==Classification== | ==Classification== | ||
* Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis. | * Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.<ref name="patho">Langerhans cell histiocytosis. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis#cite_note-10 Accessed on February, 3 2016</ref> | ||
* The table below lists the features of each specific Langerhans cell histiocytosis subtype: | * The table below lists the features of each specific Langerhans cell histiocytosis subtype: | ||
Revision as of 13:12, 4 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.[1]
Classification
- Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.[1]
- The table below lists the features of each specific Langerhans cell histiocytosis subtype:
| Subtype | Organ Involvement | Age | Risk Factors | Prognosis |
|---|---|---|---|---|
| Pulmonary Langerhans cell histiocytosis | Isolated pulmonary involvement | Adults | Occurs exclusively among smokers | Good prognosis with smoking cessation |
| Unifocal Langerhans cell histiocytosis | Isolated bone involvement | 2–10 years of age | Familial predisposition | Good prognosis, may spontaneously regress |
| Multifocal unisystem Langerhans cell histiocytosis | Triad of diabetes insipidus, exopthalmos, and lytic bone lesions | 2–10 years of age | Familial predisposition | Good prognosis, may spontaneously regress |
| Multifocal multisystem Langerhans cell histiocytosis | Involves skin, lungs, bone, and GI tract | < 2 years of age | Familial predisposition | Poor prognosis |
References
- ↑ 1.0 1.1 Langerhans cell histiocytosis. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis#cite_note-10 Accessed on February, 3 2016