Langerhans cell histiocytosis classification: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
 
(4 intermediate revisions by 3 users not shown)
Line 4: Line 4:


==Overview==
==Overview==
Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.
Langerhans cell histiocytosis may be classified according to the extent of [[Organ (anatomy)|organ]] involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.<ref name="patho">Langerhans cell histiocytosis. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis#cite_note-10 Accessed on February, 3 2016</ref><ref name="wiki">Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016</ref>
==Classification==
==Classification==
* Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.
* Langerhans cell histiocytosis may be classified according to the extent of [[Organ (anatomy)|organ]] involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.<ref name="patho">Langerhans cell histiocytosis. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis#cite_note-10 Accessed on February, 3 2016</ref><ref name="wiki">Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016</ref>
* The table below lists the features of each specific Langerhans cell histiocytosis subtype:
* The table below lists the features of each specific Langerhans cell histiocytosis subtype:<ref name="pmid25899682">{{cite journal |vauthors=Elia D, Torre O, Cassandro R, Caminati A, Harari S |title=Pulmonary Langerhans cell histiocytosis: a comprehensive analysis of 40 patients and literature review |journal=Eur. J. Intern. Med. |volume=26 |issue=5 |pages=351–6 |date=June 2015 |pmid=25899682 |doi=10.1016/j.ejim.2015.04.001 |url=}}</ref><ref name="pmid8417735">{{cite journal |vauthors=Goldsmith AJ, Myssiorek D, Valderrama E, Patel M |title=Unifocal Langerhans' cell histiocytosis (eosinophilic granuloma) of the petrous apex |journal=Arch. Otolaryngol. Head Neck Surg. |volume=119 |issue=1 |pages=113–6 |date=January 1993 |pmid=8417735 |doi= |url=}}</ref><ref name="pmid19779766">{{cite journal |vauthors=Imashuku S, Kinugawa N, Matsuzaki A, Kitoh T, Ohki K, Shioda Y, Tsunematsu Y, Imamura T, Morimoto A |title=Langerhans cell histiocytosis with multifocal bone lesions: comparative clinical features between single and multi-systems |journal=Int. J. Hematol. |volume=90 |issue=4 |pages=506–512 |date=November 2009 |pmid=19779766 |doi=10.1007/s12185-009-0420-4 |url=}}</ref>


{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
|valign=top|
| valign="top" |
|+
|+
! style="background: #4479BA; width: 650px; color: #FFFFFF;"|'''Subtype'''
! style="background: #4479BA; width: 650px; color: #FFFFFF;" |'''Subtype'''


! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Organ Involvement'''
! style="background: #4479BA; width: 600px; color: #FFFFFF;" |'''Organ Involvement'''


! style="background: #4479BA; width: 400px; color: #FFFFFF;"|'''Age'''
! style="background: #4479BA; width: 400px; color: #FFFFFF;" |'''Age'''


! style="background: #4479BA; width: 300px; color: #FFFFFF;"|'''Risk Factors'''
! style="background: #4479BA; width: 300px; color: #FFFFFF;" |'''Risk Factors'''


! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Prognosis'''
! style="background: #4479BA; width: 600px; color: #FFFFFF;" |'''Prognosis'''
|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Pulmonary Langerhans cell histiocytosis'''
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" | '''Pulmonary Langerhans cell histiocytosis'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Isolated pulmonary involvement  
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Isolated [[pulmonary]] involvement  
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Adults
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Adults
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Occurs exclusively among smokers
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Occurs exclusively among smokers
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Good prognosis with smoking cessation  
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Good [[prognosis]] with smoking cessation  
|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Unifocal Langerhans cell histiocytosis'''
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" | '''Unifocal Langerhans cell histiocytosis'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Isolated bone involvement  
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Isolated [[bone]] involvement  
| style="padding: 5px 5px; background: #F5F5F5;" align=center |2–10 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |2–10 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Familial predisposition  
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Familial predisposition  
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Good prognosis, may spontaneously regress
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Good [[prognosis]], may spontaneously regress
|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Multifocal unisystem Langerhans cell histiocytosis'''
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" | '''Multifocal unisystem Langerhans cell histiocytosis'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Triad of diabetes insipidus, exopthalmos, and lytic bone lesions
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Triad of [[diabetes insipidus]], [[Exophthalmos|exopthalmos]], and lytic bone lesions
| style="padding: 5px 5px; background: #F5F5F5;" align=center |2–10 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |2–10 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Familial predisposition  
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Familial predisposition  
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Good prognosis, may spontaneously regress
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Good [[prognosis]], may spontaneously regress
|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Multifocal multisystem Langerhans cell histiocytosis'''
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" | '''Multifocal multisystem Langerhans cell histiocytosis'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Involves skin, lungs, bone, and GI tract
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Involves [[skin]], [[lungs]], [[bone]], and [[Gastrointestinal tract|GI tract]]
| style="padding: 5px 5px; background: #F5F5F5;" align=center |< 2 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |< 2 years of age
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Familial predisposition  
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Familial predisposition  
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Poor prognosis
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Poor [[prognosis]]
|-
|-
|}
|}
Line 62: Line 62:
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Dermatology]]
[[Category:Surgery]]

Latest revision as of 18:40, 23 March 2019

Langerhans cell histiocytosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Langerhans cell histiocytosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Langerhans cell histiocytosis classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Langerhans cell histiocytosis classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Langerhans cell histiocytosis classification

on Langerhans cell histiocytosis classification

Langerhans cell histiocytosis classification in the news

Blogs on Langerhans cell histiocytosis classification

Directions to Hospitals Treating Langerhans cell histiocytosis

Risk calculators and risk factors for Langerhans cell histiocytosis classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Langerhans cell histiocytosis may be classified according to the extent of organ involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.[1][2]

Classification

  • Langerhans cell histiocytosis may be classified according to the extent of organ involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.[1][2]
  • The table below lists the features of each specific Langerhans cell histiocytosis subtype:[3][4][5]
Subtype Organ Involvement Age Risk Factors Prognosis
Pulmonary Langerhans cell histiocytosis Isolated pulmonary involvement Adults Occurs exclusively among smokers Good prognosis with smoking cessation
Unifocal Langerhans cell histiocytosis Isolated bone involvement 2–10 years of age Familial predisposition Good prognosis, may spontaneously regress
Multifocal unisystem Langerhans cell histiocytosis Triad of diabetes insipidus, exopthalmos, and lytic bone lesions 2–10 years of age Familial predisposition Good prognosis, may spontaneously regress
Multifocal multisystem Langerhans cell histiocytosis Involves skin, lungs, bone, and GI tract < 2 years of age Familial predisposition Poor prognosis

References

  1. ↑ 1.0 1.1 Langerhans cell histiocytosis. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis#cite_note-10 Accessed on February, 3 2016
  2. ↑ 2.0 2.1 Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016
  3. ↑ Elia D, Torre O, Cassandro R, Caminati A, Harari S (June 2015). "Pulmonary Langerhans cell histiocytosis: a comprehensive analysis of 40 patients and literature review". Eur. J. Intern. Med. 26 (5): 351–6. doi:10.1016/j.ejim.2015.04.001. PMID 25899682.
  4. ↑ Goldsmith AJ, Myssiorek D, Valderrama E, Patel M (January 1993). "Unifocal Langerhans' cell histiocytosis (eosinophilic granuloma) of the petrous apex". Arch. Otolaryngol. Head Neck Surg. 119 (1): 113–6. PMID 8417735.
  5. ↑ Imashuku S, Kinugawa N, Matsuzaki A, Kitoh T, Ohki K, Shioda Y, Tsunematsu Y, Imamura T, Morimoto A (November 2009). "Langerhans cell histiocytosis with multifocal bone lesions: comparative clinical features between single and multi-systems". Int. J. Hematol. 90 (4): 506–512. doi:10.1007/s12185-009-0420-4. PMID 19779766.


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Langerhans_cell_histiocytosis_classification&oldid=1558864"