LATS2: Difference between revisions

Jump to navigation Jump to search
m (Bot: HTTP→HTTPS)
m (Fixed disambiguation link)
Line 1: Line 1:
{{expert needed|1=genetics|date=July 2017}}
{{expert needed|1=genetics|date=July 2017}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Serine/threonine-protein kinase LATS2''' is an [[enzyme]] that in humans is encoded by the ''LATS2'' [[gene]].<ref name="pmid10673337">{{cite journal |vauthors=Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H | title = Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts | journal = Genomics | volume = 63 | issue = 2 | pages = 263–70 |date=Apr 2000 | pmid = 10673337 | pmc =  | doi = 10.1006/geno.1999.6065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
'''Large tumor suppressor kinase 2 (LATS2)''' is an [[enzyme]] that in humans is encoded by the ''LATS2'' [[gene]].<ref name="pmid10673337">{{cite journal |vauthors=Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H | title = Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts | journal = Genomics | volume = 63 | issue = 2 | pages = 263–70 |date=Apr 2000 | pmid = 10673337 | pmc =  | doi = 10.1006/geno.1999.6065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a [[positive feedback]] loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
| summary_text = This gene encodes a [[serine/threonine protein kinase]] belonging to the LATS [[tumor suppressor]] family. The protein localizes to [[centrosomes]] during [[interphase]], and early and late [[metaphase]]. It interacts with the centrosomal proteins [[Aurora A kinase|aurora-A]] and [[JUB (gene)|ajuba]] and is required for accumulation of [[Tubulin#γ-Tubulin|gamma-tubulin]] and [[spindle apparatus|spindle]] formation at the onset of [[mitosis]]. It also interacts with a [[negative regulator]] of [[p53]] and may function in a [[positive feedback]] loop with p53 that responds to [[cytoskeleton]] damage. Additionally, it can function as a [[corepressor]] of [[Hormone response element|androgen-responsive gene]] expression.<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
}}
}}



Revision as of 20:27, 27 June 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.[1][2]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a corepressor of androgen-responsive gene expression.[2]

References

  1. Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.
  2. 2.0 2.1 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

Further reading