LATS2: Difference between revisions

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'''Serine/threonine-protein kinase LATS2''' is an [[enzyme]] that in humans is encoded by the ''LATS2'' [[gene]].<ref name="pmid10673337">{{cite journal |vauthors=Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H | title = Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts | journal = Genomics | volume = 63 | issue = 2 | pages = 263–70 |date=Apr 2000 | pmid = 10673337 | pmc =  | doi = 10.1006/geno.1999.6065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = LATS, large tumor suppressor, homolog 2 (Drosophila)
| HGNCid = 6515
| Symbol = LATS2
| AltSymbols =; FLJ13161; KPM
| OMIM = 604861
| ECnumber =
| Homologene = 56678
| MGIid = 1354386
  | GeneAtlas_image1 = PBB_GE_LATS2_gnf1h02724_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0000922 |text = spindle pole}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0009755 |text = hormone-mediated signaling}} {{GNF_GO|id=GO:0045736 |text = negative regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26524
    | Hs_Ensembl = ENSG00000150457
    | Hs_RefseqProtein = NP_055387
    | Hs_RefseqmRNA = NM_014572
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 20445171
    | Hs_GenLoc_end = 20533686
    | Hs_Uniprot = Q9NRM7
    | Mm_EntrezGene = 50523
    | Mm_Ensembl = ENSMUSG00000021959
    | Mm_RefseqmRNA = NM_015771
    | Mm_RefseqProtein = NP_056586
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 56643772
    | Mm_GenLoc_end = 56700233
    | Mm_Uniprot = Q7TSJ6
  }}
}}
'''LATS, large tumor suppressor, homolog 2 (Drosophila)''', also known as '''LATS2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
| summary_text = This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a [[positive feedback]] loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yabuta N, Fujii T, Copeland NG, ''et al.'' |title=Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. |journal=Genomics |volume=63 |issue= 2 |pages= 263-70 |year= 2000 |pmid= 10673337 |doi= 10.1006/geno.1999.6065 }}
*{{cite journal  |vauthors=Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T |title=Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. |journal=Oncogene |volume=19 |issue= 27 |pages= 3101–9 |year= 2000 |pmid= 10871863 |doi= 10.1038/sj.onc.1203659 }}
*{{cite journal  | author=Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T |title=Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. |journal=Oncogene |volume=19 |issue= 27 |pages= 3101-9 |year= 2000 |pmid= 10871863 |doi= 10.1038/sj.onc.1203659 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Li Y, Pei J, Xia H, etal |title=Lats2, a putative tumor suppressor, inhibits G1/S transition. |journal=Oncogene |volume=22 |issue= 28 |pages= 4398–405 |year= 2003 |pmid= 12853976 |doi= 10.1038/sj.onc.1206603 }}
*{{cite journal | author=Li Y, Pei J, Xia H, ''et al.'' |title=Lats2, a putative tumor suppressor, inhibits G1/S transition. |journal=Oncogene |volume=22 |issue= 28 |pages= 4398-405 |year= 2003 |pmid= 12853976 |doi= 10.1038/sj.onc.1206603 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Powzaniuk M, McElwee-Witmer S, Vogel RL, etal |title=The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. |journal=Mol. Endocrinol. |volume=18 |issue= 8 |pages= 2011–23 |year= 2005 |pmid= 15131260 |doi= 10.1210/me.2004-0065 }}
*{{cite journal | author=Powzaniuk M, McElwee-Witmer S, Vogel RL, ''et al.'' |title=The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. |journal=Mol. Endocrinol. |volume=18 |issue= 8 |pages= 2011-23 |year= 2005 |pmid= 15131260 |doi= 10.1210/me.2004-0065 }}
*{{cite journal   |vauthors=Toji S, Yabuta N, Hosomi T, etal |title=The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. |journal=Genes Cells |volume=9 |issue= 5 |pages= 383–97 |year= 2005 |pmid= 15147269 |doi= 10.1111/j.1356-9597.2004.00732.x }}
*{{cite journal | author=Toji S, Yabuta N, Hosomi T, ''et al.'' |title=The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. |journal=Genes Cells |volume=9 |issue= 5 |pages= 383-97 |year= 2005 |pmid= 15147269 |doi= 10.1111/j.1356-9597.2004.00732.x }}
*{{cite journal   |vauthors=Ke H, Pei J, Ni Z, etal |title=Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). |journal=Exp. Cell Res. |volume=298 |issue= 2 |pages= 329–38 |year= 2004 |pmid= 15265683 |doi= 10.1016/j.yexcr.2004.04.031 }}
*{{cite journal | author=Ke H, Pei J, Ni Z, ''et al.'' |title=Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). |journal=Exp. Cell Res. |volume=298 |issue= 2 |pages= 329-38 |year= 2004 |pmid= 15265683 |doi= 10.1016/j.yexcr.2004.04.031 }}
*{{cite journal   |vauthors=Chan EH, Nousiainen M, Chalamalasetty RB, etal |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |journal=Oncogene |volume=24 |issue= 12 |pages= 2076–86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445 }}
*{{cite journal | author=Chan EH, Nousiainen M, Chalamalasetty RB, ''et al.'' |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |journal=Oncogene |volume=24 |issue= 12 |pages= 2076-86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445 }}
*{{cite journal   |vauthors=Takahashi Y, Miyoshi Y, Takahata C, etal |title=Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. |journal=Clin. Cancer Res. |volume=11 |issue= 4 |pages= 1380–5 |year= 2005 |pmid= 15746036 |doi= 10.1158/1078-0432.CCR-04-1773 }}
*{{cite journal | author=Takahashi Y, Miyoshi Y, Takahata C, ''et al.'' |title=Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. |journal=Clin. Cancer Res. |volume=11 |issue= 4 |pages= 1380-5 |year= 2005 |pmid= 15746036 |doi= 10.1158/1078-0432.CCR-04-1773 }}
*{{cite journal   |vauthors=Abe Y, Ohsugi M, Haraguchi K, etal |title=LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. |journal=FEBS Lett. |volume=580 |issue= 3 |pages= 782–8 |year= 2006 |pmid= 16413547 |doi= 10.1016/j.febslet.2005.12.096 }}
*{{cite journal | author=Abe Y, Ohsugi M, Haraguchi K, ''et al.'' |title=LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. |journal=FEBS Lett. |volume=580 |issue= 3 |pages= 782-8 |year= 2006 |pmid= 16413547 |doi= 10.1016/j.febslet.2005.12.096 }}
*{{cite journal   |vauthors=Voorhoeve PM, le Sage C, Schrier M, etal |title=A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. |journal=Cell |volume=124 |issue= 6 |pages= 1169–81 |year= 2006 |pmid= 16564011 |doi= 10.1016/j.cell.2006.02.037 }}
*{{cite journal | author=Voorhoeve PM, le Sage C, Schrier M, ''et al.'' |title=A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. |journal=Cell |volume=124 |issue= 6 |pages= 1169-81 |year= 2006 |pmid= 16564011 |doi= 10.1016/j.cell.2006.02.037 }}
*{{cite journal   |vauthors=Aylon Y, Michael D, Shmueli A, etal |title=A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. |journal=Genes Dev. |volume=20 |issue= 19 |pages= 2687–700 |year= 2007 |pmid= 17015431 |doi= 10.1101/gad.1447006 | pmc=1578695 }}
*{{cite journal | author=Aylon Y, Michael D, Shmueli A, ''et al.'' |title=A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. |journal=Genes Dev. |volume=20 |issue= 19 |pages= 2687-700 |year= 2007 |pmid= 17015431 |doi= 10.1101/gad.1447006 }}
*{{cite journal   |vauthors=Jiang Z, Li X, Hu J, etal |title=Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. |journal=Neurosci. Res. |volume=56 |issue= 4 |pages= 450–8 |year= 2007 |pmid= 17049657 |doi= 10.1016/j.neures.2006.09.006 }}
*{{cite journal | author=Jiang Z, Li X, Hu J, ''et al.'' |title=Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. |journal=Neurosci. Res. |volume=56 |issue= 4 |pages= 450-8 |year= 2007 |pmid= 17049657 |doi= 10.1016/j.neures.2006.09.006 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Serine/threonine-specific protein kinases}}
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Revision as of 17:35, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.[1][2]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.[2]

References

  1. ↑ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.
  2. ↑ 2.0 2.1 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

Further reading


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