LATS2: Difference between revisions

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'''Serine/threonine-protein kinase LATS2''' is an [[enzyme]] that in humans is encoded by the ''LATS2'' [[gene]].<ref name="pmid10673337">{{cite journal |vauthors=Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H | title = Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts | journal = Genomics | volume = 63 | issue = 2 | pages = 263–70 |date=Apr 2000 | pmid = 10673337 | pmc =  | doi = 10.1006/geno.1999.6065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
'''Large tumor suppressor kinase 2 (LATS2)''' is an [[enzyme]] that in humans is encoded by the ''LATS2'' [[gene]].<ref name="pmid10673337">{{cite journal |vauthors=Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H | title = Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts | journal = Genomics | volume = 63 | issue = 2 | pages = 263–70 |date=Apr 2000 | pmid = 10673337 | pmc =  | doi = 10.1006/geno.1999.6065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>


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| summary_text = This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a [[positive feedback]] loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
| summary_text = This gene encodes a [[serine/threonine protein kinase]] belonging to the LATS [[tumor suppressor]] family. The protein localizes to [[centrosomes]] during [[interphase]], and early and late [[metaphase]]. It interacts with the centrosomal proteins [[Aurora A kinase|aurora-A]] and [[JUB (gene)|ajuba]] and is required for accumulation of [[Tubulin#γ-Tubulin|gamma-tubulin]] and [[spindle apparatus|spindle]] formation at the onset of [[mitosis]]. It also interacts with a [[negative regulator]] of [[p53]] and may function in a [[positive feedback]] loop with p53 that responds to [[cytoskeleton]] damage. Additionally, it can function as a [[corepressor]] of [[Hormone response element|androgen-responsive gene]] expression.<ref name="entrez">{{cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = }}</ref>
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Latest revision as of 11:35, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.[1][2]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a corepressor of androgen-responsive gene expression.[2]

References

  1. ↑ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.
  2. ↑ 2.0 2.1 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

Further reading


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