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{{Infobox_gene}}
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'''Serine/threonine-protein kinase LATS1''' is an [[enzyme]] that in humans is encoded by the ''LATS1'' [[gene]].<ref name="pmid9988268">{{cite journal |vauthors=Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T | title = Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity | journal = Nat Genet | volume = 21 | issue = 2 | pages = 177–81 |date=February 1999 | pmid = 9988268 | pmc =  | doi = 10.1038/5960 }}</ref><ref name="pmid15122335">{{cite journal |vauthors=Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H | title = Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function | journal = Oncogene | volume = 23 | issue = 31 | pages = 5266–74 |date=July 2004 | pmid = 15122335 | pmc = | doi = 10.1038/sj.onc.1207623 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9113| accessdate = }}</ref>
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It has been associated with the [[Hippo signaling pathway]].<ref name="pmid18158288">{{cite journal |vauthors=Hao Y, Chun A, Cheung K, Rashidi B, Yang X |title=Tumor suppressor LATS1 is a negative regulator of oncogene YAP |journal=J. Biol. Chem. |volume=283 |issue=9 |pages=5496–509 |date=February 2008 |pmid=18158288 |doi=10.1074/jbc.M709037200 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=18158288}}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = LATS, large tumor suppressor, homolog 1 (Drosophila)
| HGNCid = 6514
| Symbol = LATS1
| AltSymbols =; WARTS; wts
| OMIM = 603473
| ECnumber = 
| Homologene = 55843
| MGIid = 1333883
| GeneAtlas_image1 = PBB_GE_LATS1_219813_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}}
| Component = {{GNF_GO|id=GO:0000922 |text = spindle pole}}
| Process = {{GNF_GO|id=GO:0000086 |text = G2/M transition of mitotic cell cycle}} {{GNF_GO|id=GO:0000819 |text = sister chromatid segregation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0009755 |text = hormone-mediated signaling}} {{GNF_GO|id=GO:0030833 |text = regulation of actin filament polymerization}} {{GNF_GO|id=GO:0045736 |text = negative regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9113
    | Hs_Ensembl = ENSG00000131023
    | Hs_RefseqProtein = NP_004681
    | Hs_RefseqmRNA = NM_004690
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 150023744
    | Hs_GenLoc_end = 150081085
    | Hs_Uniprot = O95835
    | Mm_EntrezGene = 16798
    | Mm_Ensembl = ENSMUSG00000040021
    | Mm_RefseqmRNA = XM_618738
    | Mm_RefseqProtein = XP_618738
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 7381657
    | Mm_GenLoc_end = 7403525
    | Mm_Uniprot = Q8BYR2
  }}
}}
'''LATS, large tumor suppressor, homolog 1 (Drosophila)''', also known as '''LATS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9113| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.<ref name="entrez">{{cite web | title = Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9113| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.<ref name="entrez"/>
}}
}}
==Interactions==
LATS1 has been shown to [[Protein-protein interaction|interact]] with [[Zyxin]]<ref name=pmid10831611>{{cite journal |last=Hirota |first=T |authorlink= |author2=Morisaki T |author3=Nishiyama Y |author4=Marumoto T |author5=Tada K |author6=Hara T |author7=Masuko N |author8=Inagaki M |author9=Hatakeyama K |author10=Saya H  |date=May 2000 |title=Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor |journal=J. Cell Biol. |volume=149 |issue=5 |pages=1073–86 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 10831611 | bibcode = | oclc =| id = | url = | language =  |pmc=2174824| format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.149.5.1073 }}</ref> and [[Cdk1]].<ref name=pmid9988268 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
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| citations =  
| citations =  
*{{cite journal | author=Xu T, Wang W, Zhang S, ''et al.'' |title=Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. |journal=Development |volume=121 |issue= 4 |pages= 1053-63 |year= 1995 |pmid= 7743921 |doi=  }}
*{{cite journal   |vauthors=Xu T, Wang W, Zhang S, etal |title=Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. |journal=Development |volume=121 |issue= 4 |pages= 1053–63 |year= 1995 |pmid= 7743921 |doi=  }}
*{{cite journal | author=Tao W, Zhang S, Turenchalk GS, ''et al.'' |title=Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 177-81 |year= 1999 |pmid= 9988268 |doi= 10.1038/5960 }}
*{{cite journal   |vauthors=St John MA, Tao W, Fei X, etal |title=Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 182–6 |year= 1999 |pmid= 9988269 |doi= 10.1038/5965 }}
*{{cite journal  | author=St John MA, Tao W, Fei X, ''et al.'' |title=Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 182-6 |year= 1999 |pmid= 9988269 |doi= 10.1038/5965 }}
*{{cite journal   |vauthors=Nishiyama Y, Hirota T, Morisaki T, etal |title=A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 159–65 |year= 1999 |pmid= 10518011 |doi=10.1016/S0014-5793(99)01224-7 }}
*{{cite journal | author=Nishiyama Y, Hirota T, Morisaki T, ''et al.'' |title=A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 159-65 |year= 1999 |pmid= 10518011 |doi=  }}
*{{cite journal   |vauthors=Hirota T, Morisaki T, Nishiyama Y, etal |title=Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. |journal=J. Cell Biol. |volume=149 |issue= 5 |pages= 1073–86 |year= 2000 |pmid= 10831611 |doi=10.1083/jcb.149.5.1073  | pmc=2174824 }}
*{{cite journal | author=Hirota T, Morisaki T, Nishiyama Y, ''et al.'' |title=Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. |journal=J. Cell Biol. |volume=149 |issue= 5 |pages= 1073-86 |year= 2000 |pmid= 10831611 |doi=  }}
*{{cite journal   |vauthors=Morisaki T, Hirota T, Iida S, etal |title=WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. |journal=FEBS Lett. |volume=529 |issue= 2–3 |pages= 319–24 |year= 2002 |pmid= 12372621 |doi=10.1016/S0014-5793(02)03360-4 }}
*{{cite journal | author=Morisaki T, Hirota T, Iida S, ''et al.'' |title=WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 319-24 |year= 2002 |pmid= 12372621 |doi=  }}
*{{cite journal  |vauthors=Hisaoka M, Tanaka A, Hashimoto H |title=Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma |journal=Lab. Invest. |volume=82 |issue= 10 |pages= 1427–35 |year= 2002 |pmid= 12379777 |doi=  10.1097/01.lab.0000032381.68634.ca}}
*{{cite journal  | author=Hisaoka M, Tanaka A, Hashimoto H |title=Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. |journal=Lab. Invest. |volume=82 |issue= 10 |pages= 1427-35 |year= 2002 |pmid= 12379777 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Kamikubo Y, Takaori-Kondo A, Uchiyama T, Hori T |title=Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17609–14 |year= 2003 |pmid= 12624101 |doi= 10.1074/jbc.M211974200 }}
*{{cite journal  | author=Kamikubo Y, Takaori-Kondo A, Uchiyama T, Hori T |title=Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17609-14 |year= 2003 |pmid= 12624101 |doi= 10.1074/jbc.M211974200 }}
*{{cite journal   |vauthors=Brill LM, Salomon AR, Ficarro SB, etal |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Iida S, Hirota T, Morisaki T, ''et al.'' |title=Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. |journal=Oncogene |volume=23 |issue= 31 |pages= 5266-74 |year= 2004 |pmid= 15122335 |doi= 10.1038/sj.onc.1207623 }}
*{{cite journal   |vauthors=Yang X, Yu K, Hao Y, etal |title=LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 |journal=Nat. Cell Biol. |volume=6 |issue= 7 |pages= 609–17 |year= 2004 |pmid= 15220930 |doi= 10.1038/ncb1140 }}
*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Yang X, Yu K, Hao Y, ''et al.'' |title=LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. |journal=Nat. Cell Biol. |volume=6 |issue= 7 |pages= 609-17 |year= 2004 |pmid= 15220930 |doi= 10.1038/ncb1140 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Chan EH, Nousiainen M, Chalamalasetty RB, etal |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 |journal=Oncogene |volume=24 |issue= 12 |pages= 2076–86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Takahashi Y, Miyoshi Y, Takahata C, etal |title=Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers |journal=Clin. Cancer Res. |volume=11 |issue= 4 |pages= 1380–5 |year= 2005 |pmid= 15746036 |doi= 10.1158/1078-0432.CCR-04-1773 }}
*{{cite journal | author=Chan EH, Nousiainen M, Chalamalasetty RB, ''et al.'' |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |journal=Oncogene |volume=24 |issue= 12 |pages= 2076-86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445 }}
*{{cite journal   |vauthors=Kuninaka S, Nomura M, Hirota T, etal |title=The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death |journal=Oncogene |volume=24 |issue= 34 |pages= 5287–98 |year= 2005 |pmid= 16007220 |doi= 10.1038/sj.onc.1208682 }}
*{{cite journal | author=Takahashi Y, Miyoshi Y, Takahata C, ''et al.'' |title=Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. |journal=Clin. Cancer Res. |volume=11 |issue= 4 |pages= 1380-5 |year= 2005 |pmid= 15746036 |doi= 10.1158/1078-0432.CCR-04-1773 }}
*{{cite journal   |vauthors=Bothos J, Tuttle RL, Ottey M, etal |title=Human LATS1 is a mitotic exit network kinase |journal=Cancer Res. |volume=65 |issue= 15 |pages= 6568–75 |year= 2005 |pmid= 16061636 |doi= 10.1158/0008-5472.CAN-05-0862 }}
*{{cite journal | author=Kuninaka S, Nomura M, Hirota T, ''et al.'' |title=The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death. |journal=Oncogene |volume=24 |issue= 34 |pages= 5287-98 |year= 2005 |pmid= 16007220 |doi= 10.1038/sj.onc.1208682 }}
*{{cite journal   |vauthors=Jiang Z, Li X, Hu J, etal |title=Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma |journal=Neurosci. Res. |volume=56 |issue= 4 |pages= 450–8 |year= 2007 |pmid= 17049657 |doi= 10.1016/j.neures.2006.09.006 }}
*{{cite journal | author=Bothos J, Tuttle RL, Ottey M, ''et al.'' |title=Human LATS1 is a mitotic exit network kinase. |journal=Cancer Res. |volume=65 |issue= 15 |pages= 6568-75 |year= 2005 |pmid= 16061636 |doi= 10.1158/0008-5472.CAN-05-0862 }}
*{{cite journal | author=Jiang Z, Li X, Hu J, ''et al.'' |title=Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. |journal=Neurosci. Res. |volume=56 |issue= 4 |pages= 450-8 |year= 2007 |pmid= 17049657 |doi= 10.1016/j.neures.2006.09.006 }}
}}
}}
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{{refend}}


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{{Hippo signaling pathway}}
{{Serine/threonine-specific protein kinases}}
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Revision as of 17:35, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.[1][2][3]

It has been associated with the Hippo signaling pathway.[4]

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.[3]

Interactions

LATS1 has been shown to interact with Zyxin[5] and Cdk1.[1]

References

  1. ↑ 1.0 1.1 Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T (February 1999). "Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity". Nat Genet. 21 (2): 177–81. doi:10.1038/5960. PMID 9988268.
  2. ↑ Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H (July 2004). "Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function". Oncogene. 23 (31): 5266–74. doi:10.1038/sj.onc.1207623. PMID 15122335.
  3. ↑ 3.0 3.1 "Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)".
  4. ↑ Hao Y, Chun A, Cheung K, Rashidi B, Yang X (February 2008). "Tumor suppressor LATS1 is a negative regulator of oncogene YAP". J. Biol. Chem. 283 (9): 5496–509. doi:10.1074/jbc.M709037200. PMID 18158288.
  5. ↑ Hirota, T; Morisaki T; Nishiyama Y; Marumoto T; Tada K; Hara T; Masuko N; Inagaki M; Hatakeyama K; Saya H (May 2000). "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor". J. Cell Biol. UNITED STATES. 149 (5): 1073–86. doi:10.1083/jcb.149.5.1073. ISSN 0021-9525. PMC 2174824. PMID 10831611.

Further reading



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