KDM4D: Difference between revisions

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{{Infobox_gene}}
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'''Lysine-specific demethylase 4D''' is an [[enzyme]] that in humans is encoded by the ''KDM4D'' [[gene]].<ref name="pmid15138608">{{cite journal |vauthors=Katoh M, Katoh M | title = Identification and characterization of JMJD2 family genes in silico | journal = Int J Oncol | volume = 24 | issue = 6 | pages = 1623–8 |date=May 2004 | pmid = 15138608 | pmc =  | doi = 10.3892/ijo.25.3.759}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: JMJD2D jumonji domain containing 2D| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55693| accessdate = }}</ref> KDM4D belongs to the [[2-oxoglutarate (2OG)-dependent dioxygenases | 2-oxoglutarate (2OG)-dependent dioxygenase]] superfamily.
'''Lysine-specific demethylase 4D''' is an [[enzyme]] that in humans is encoded by the ''KDM4D'' [[gene]].<ref name="pmid15138608">{{cite journal | vauthors = Katoh M, Katoh M | title = Identification and characterization of JMJD2 family genes in silico | journal = International Journal of Oncology | volume = 24 | issue = 6 | pages = 1623–8 | date = June 2004 | pmid = 15138608 | pmc =  | doi = 10.3892/ijo.25.3.759 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: JMJD2D jumonji domain containing 2D| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55693| accessdate = }}</ref> KDM4D belongs to the [[alpha-ketoglutarate-dependent hydroxylase]] superfamily.


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In 2017, messenger RNA from this gene was used in the {{w|somatic cell nuclear transfer}} experiment that produced the first two cloned primates from post-embryonic donor material.<ref>{{cite journal | vauthors = Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q | title = Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer | journal = Cell | volume = 172 | issue = 4 | pages = 881–887.e7 | date = February 2018 | pmid = 29395327 | doi = 10.1016/j.cell.2018.01.020 }}</ref><ref>{{cite article | url = https://www.npr.org/sections/health-shots/2018/01/24/579925801/chinese-scientists-clone-monkeys-using-method-that-created-dolly-the-sheep |title  = Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep | first = Rob | last = Stein | name-list-format = vanc | journal = National Public Radio | date = 24 January 2018 | accessdate = 24 January 2018 }}</ref>. A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.<ref>{{cite journal | vauthors = Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y | title = H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming | journal = Development | volume = 145 | issue = 4 | date = February 2018 | pmid = 29453221 | doi = 10.1242/dev.158261 }}</ref>
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==References==
{{wikinews|Healthy cloned monkeys born in Shanghai}}
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Shin S, Janknecht R | title = Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D | journal = Biochemical and Biophysical Research Communications | volume = 359 | issue = 3 | pages = 742–6 | date = August 2007 | pmid = 17555712 | doi = 10.1016/j.bbrc.2007.05.179 }}
| citations =
* {{cite journal | vauthors = Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y | title = Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases | journal = Cell | volume = 125 | issue = 3 | pages = 467–81 | date = May 2006 | pmid = 16603238 | doi = 10.1016/j.cell.2006.03.028 }}
*{{cite journal |vauthors=Shin S, Janknecht R |title=Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 3 |pages= 742–6 |year= 2007 |pmid= 17555712 |doi= 10.1016/j.bbrc.2007.05.179 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal   |vauthors=Whetstine JR, Nottke A, Lan F, etal |title=Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. |journal=Cell |volume=125 |issue= 3 |pages= 467–81 |year= 2006 |pmid= 16603238 |doi= 10.1016/j.cell.2006.03.028 }}
*{{cite journal   |vauthors=Taylor TD, Noguchi H, Totoki Y, etal |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497–500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
}}
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{{refend}}


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{{Portal bar|Molecular and Cellular Biology|border=no}}
{{Portal bar|Molecular and Cellular Biology|border=no}}


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[[Category:Human 2OG oxygenases]]
[[Category:Human 2OG oxygenases]]
[[Category:EC 1.14.11]]
[[Category:EC 1.14.11]]


{{gene-11-stub}}
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Latest revision as of 18:35, 6 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene.[1][2] KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material.[3][4]. A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.[5]

References

  1. Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
  2. "Entrez Gene: JMJD2D jumonji domain containing 2D".
  3. Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q (February 2018). "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell. 172 (4): 881–887.e7. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
  4. Stein R (24 January 2018). "Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep". National Public Radio. Retrieved 24 January 2018.
  5. Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y (February 2018). "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming". Development. 145 (4). doi:10.1242/dev.158261. PMID 29453221.

Further reading

  • Shin S, Janknecht R (August 2007). "Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D". Biochemical and Biophysical Research Communications. 359 (3): 742–6. doi:10.1016/j.bbrc.2007.05.179. PMID 17555712.
  • Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y (May 2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10.1016/j.cell.2006.03.028. PMID 16603238.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.