Ileus medical therapy: Difference between revisions

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==Overview==
==Overview==
[[Nil per os]] (NPO or Nothing by Mouth) is mandatory in all cases. [[Nasogastric intubation|Nasogastric suction]] and [[parenteral]] feeds may be required until passage is restored. There are several options in the case of paralytic ileus. Most treatment is supportive. If caused by medication, the offending agent is discontinued or reduced. Bowel movements may be stimulated by prescribing [[lactulose]], [[erythromycin]] or in severe cases, ([[Ogilvie's syndrome]]) [[neostigmine]]. If possible the underlying cause is corrected (e.g. replace electrolytes).
The majority of cases of [[ileus]] are resolved with correction of underlying [[Electrolyte abnormalities|electrolyte disorder]] and only require supportive care. [[Intravenous]] [[Fluid replacement|hydration]] is advised with appropriate rapid supplementation for [[Electrolyte abnormalities|electrolyte abnormalities.]] [[NSAID]]<nowiki/>s are used as baseline [[analgesic]] [[medication|medications]]. In contrast, [[opiates]] and antimotility drugs (such as [[Vagus nerve|vagolytic]] agents) should be avoided generally, although [[opiates]] are sometimes used in case of severe intractable [[pain]]. [[patient|Patients]] are put on [[NPO]] and [[nasogastric tube]] is advised to relieve recurrent [[vomiting]] or [[Abdominal distension|abdominal distention]] associated with [[pain]]. [[Prokinetic|Prokinetic agents]] such as [[erythromycin]] are not routinely recommended. In [[ileus|paralytic ilues]] certain [[medication|medications]] such as [[hyoscyamine]], [[methscopolamine bromide]], [[oxycodone]], [[polyethylene glycol-electrolyte solution]] ([[polyethylene glycol-electrolyte solution|PEG-ES]]) are [[Contraindication|contraindicated]].
 
==Medical Therapy==
[[therapy|Medical therapy]] for [[ileus]] includes correcting the underlying condition and supportive [[therapy]].<ref name="pmid26703957">{{cite journal |vauthors=Bruns BR, Kozar RA |title=Feeding the Postoperative Patient on Vasopressor Support: Feeding and Pressor Support |journal=Nutr Clin Pract |volume=31 |issue=1 |pages=14–7 |year=2016 |pmid=26703957 |doi=10.1177/0884533615619932 |url=}}</ref><ref name="pmid10696888">{{cite journal |vauthors=Cali RL, Meade PG, Swanson MS, Freeman C |title=Effect of Morphine and incision length on bowel function after colectomy |journal=Dis. Colon Rectum |volume=43 |issue=2 |pages=163–8 |year=2000 |pmid=10696888 |doi= |url=}}</ref><ref name="pmid25503902">{{cite journal |vauthors=Wu Z, Boersema GS, Dereci A, Menon AG, Jeekel J, Lange JF |title=Clinical endpoint, early detection, and differential diagnosis of postoperative ileus: a systematic review of the literature |journal=Eur Surg Res |volume=54 |issue=3-4 |pages=127–38 |year=2015 |pmid=25503902 |doi=10.1159/000369529 |url=}}</ref><ref name="pmid19209273">{{cite journal |vauthors=Lubawski J, Saclarides T |title=Postoperative ileus: strategies for reduction |journal=Ther Clin Risk Manag |volume=4 |issue=5 |pages=913–7 |year=2008 |pmid=19209273 |pmc=2621410 |doi= |url=}}</ref>
 
*[[patient|Patients]] should receive [[intravenous]] [[Fluid replacement|hydration]].
*[[patient|Patients]] of [[ileus]] from [[electrolyte abnormalities]] should be treated with appropriate supplementation.
*[[intestine|Bowel]] rest and [[Nasogastric aspiration|nasogastric decompression]] can relieve recurrent [[vomiting]] or [[Abdominal distension|abdominal distention]] associated with [[pain]].<ref name="pmid15859962">{{cite journal |vauthors=Kehlet H, Williamson R, Büchler MW, Beart RW |title=A survey of perceptions and attitudes among European surgeons towards the clinical impact and management of postoperative ileus |journal=Colorectal Dis |volume=7 |issue=3 |pages=245–50 |year=2005 |pmid=15859962 |doi=10.1111/j.1463-1318.2005.00763.x |url=}}</ref><ref name="pmid16377496">{{cite journal |vauthors=Kehlet H, Büchler MW, Beart RW, Billingham RP, Williamson R |title=Care after colonic operation--is it evidence-based? Results from a multinational survey in Europe and the United States |journal=J. Am. Coll. Surg. |volume=202 |issue=1 |pages=45–54 |year=2006 |pmid=16377496 |doi=10.1016/j.jamcollsurg.2005.08.006 |url=}}</ref>
*Antimotility drugs (such as [[Vagus nerve|vagolytic]] agents ([[butylscopolamine]]) and other [[medications]] ([[narcotics]]) which may alter [[intestine|intestinal]] [[motility]] should be stopped.
*[[Prokinetic|Prokinetic agents]] such as [[erythromycin]] are not routinely recommended.
**'''1.1 - Post-[[surgey|operative]] [[pain]]'''
*** Preferred regimen (1): [[Acetaminophen]] 1000 mg [[Orally ingested|orally]] every six hours (or [[Intravenous therapy|IV]] when [[patient]] is [[NPO]]).
*** Preferred regimen (2): Add [[diclofenac]] 50 mg [[Orally ingested|orally]] twice a day with meals for two days and adjust as-needed.
*** Preferred regimen (3): Add [[oxycodone]] 5 to 10 mg [[Orally ingested|orally]] every three hours as needed for [[pain|breakthrough pain]].
*** Alternate regimen (1): [[Hydromorphone]] 0.2 to 0.5 mg [[Intravenous therapy|IV]] every four hours as needed for [[pain|severe breakthrough pain]] not responsive to [[Orally ingested|oral]] [[mediaction|medications]].
**1.2 '''[[Fluid replacement]]'''
*** Preferred regimen (1): [[Intravenous fluid|Isotonic]] [[Saline (medicine)|saline]] (1 to 2 liters) to relieve [[Symptom|symptoms]].
***: '''Note (1):''' Rapid [[infusion]] of [[isotonic]] [[fluid]] is advised until [[symptoms]] resolve.
**'''1.3 Recurrent [[vomiting]] or [[abdominal distension]]'''
*** Preferred regimen (1): [[Nasogastric tube|Nasogastric]] ([[Nasogastric tube|NG]]) tube placement until [[symptoms]] resolve.
***: '''Note (1):''' The tip of [[Nasogastric tube|NG tube]] should be placed in the [[stomach]].
***: '''Note (2):''' To prevent [[fluid]] loss, volume of [[fluid]] removed should be replaced with [[Intravenous fluid|isotonic]] [[Saline (medicine)|saline]].


===Contraindicated medications===
===Contraindicated medications===
{{MedCondContrAbs
{{MedCondContrAbs


|MedCond =Patalytic ileus|Oxycodone}}
|MedCond =[[ileus|Paralytic ileus]]|Hyoscyamine|Methscopolamine bromide|Oxycodone|Polyethylene glycol-electrolyte solution (PEG-ES)|}}


==References==
==References==
{{Reflist|2}}


{{Reflist|2}}
[[Category:Disease]]
 
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Latest revision as of 16:50, 12 October 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]

Overview

The majority of cases of ileus are resolved with correction of underlying electrolyte disorder and only require supportive care. Intravenous hydration is advised with appropriate rapid supplementation for electrolyte abnormalities. NSAIDs are used as baseline analgesic medications. In contrast, opiates and antimotility drugs (such as vagolytic agents) should be avoided generally, although opiates are sometimes used in case of severe intractable pain. Patients are put on NPO and nasogastric tube is advised to relieve recurrent vomiting or abdominal distention associated with pain. Prokinetic agents such as erythromycin are not routinely recommended. In paralytic ilues certain medications such as hyoscyamine, methscopolamine bromide, oxycodone, polyethylene glycol-electrolyte solution (PEG-ES) are contraindicated.

Medical Therapy

Medical therapy for ileus includes correcting the underlying condition and supportive therapy.[1][2][3][4]

Contraindicated medications

Paralytic ileus is considered an absolute contraindication to the use of the following medications:

References

  1. Bruns BR, Kozar RA (2016). "Feeding the Postoperative Patient on Vasopressor Support: Feeding and Pressor Support". Nutr Clin Pract. 31 (1): 14–7. doi:10.1177/0884533615619932. PMID 26703957.
  2. Cali RL, Meade PG, Swanson MS, Freeman C (2000). "Effect of Morphine and incision length on bowel function after colectomy". Dis. Colon Rectum. 43 (2): 163–8. PMID 10696888.
  3. Wu Z, Boersema GS, Dereci A, Menon AG, Jeekel J, Lange JF (2015). "Clinical endpoint, early detection, and differential diagnosis of postoperative ileus: a systematic review of the literature". Eur Surg Res. 54 (3–4): 127–38. doi:10.1159/000369529. PMID 25503902.
  4. Lubawski J, Saclarides T (2008). "Postoperative ileus: strategies for reduction". Ther Clin Risk Manag. 4 (5): 913–7. PMC 2621410. PMID 19209273.
  5. Kehlet H, Williamson R, Büchler MW, Beart RW (2005). "A survey of perceptions and attitudes among European surgeons towards the clinical impact and management of postoperative ileus". Colorectal Dis. 7 (3): 245–50. doi:10.1111/j.1463-1318.2005.00763.x. PMID 15859962.
  6. Kehlet H, Büchler MW, Beart RW, Billingham RP, Williamson R (2006). "Care after colonic operation--is it evidence-based? Results from a multinational survey in Europe and the United States". J. Am. Coll. Surg. 202 (1): 45–54. doi:10.1016/j.jamcollsurg.2005.08.006. PMID 16377496.

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