Hypopharyngeal cancer pathophysiology
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Hypopharyngeal cancer Microchapters |
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Hypopharyngeal cancer pathophysiology On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Genes involved in the pathogenesis of hypopharyngeal cancer include p16, NOTCH1, and cyclin D1. Hypopharyngeal cancer is associated with sideropaenic dysphagia and Paterson Brown Kelly syndrome.On gross pathology, flattened plaques, mucosal ulceration, and raised margins of the lesion are characteristic findings of hypopharyngeal cancer. On microscopic histopathological analysis, spindle cells, basaloid cells, and nuclear atypia are characteristic findings of hypopharyngeal cancer.[1]
Pathophysiology
Genetics
Genes involved in the pathogenesis of hypopharyngeal cancer include:
- p16
- NOTCH1
- cyclin D1
- TP53
Associated Diseases
Hypopharyngeal carcinoma is associated with:[1]
- Sideropaenic dysphagia
- Paterson Brown Kelly syndrome
Gross Pathology
Gross pathology of hypopharyngeal cancer includes:[1]
- Flattened plaques
- Raised margins of the lesion
- Mucosal ulceration
- Tumor spread to piriform sinus
Microscopic Pathology
Microscopic features of hypopharyngeal carcinoma include:[1]
- Spindle cells
- Basaloid cells
- Nuclear atypia
- Abundant chromatin