Hypertriglyceridemia omega-3 fatty acids: Difference between revisions

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===Trial supportive data===
===Trial supportive data===
{|border="1" align="center" style="background:lightskyblue"
|-
| bgcolor="CadetBlue" |'''Study name'''
| bgcolor="CadetBlue" |'''Source & year'''
| bgcolor="CadetBlue" |'''Study question'''
| bgcolor="CadetBlue" |'''Study Design'''
| bgcolor="CadetBlue" |'''Study Population'''
| bgcolor="CadetBlue" |'''Time period'''
| bgcolor="CadetBlue" |'''Intervention'''
| bgcolor="CadetBlue" |'''Results'''
| bgcolor="CadetBlue" |'''Conclusions'''
|-
| Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia <ref name="pmid11303007">{{cite journal| author=Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA et al.| title=An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | journal=Heart | year= 2001 | volume= 85 | issue= 5 | pages= 544-8 | pmid=11303007 | doi= | pmc=PMC1729738 | url= }} </ref>
| Heart, 2001
| To access the safety and efficacy of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia
| Double blinded randomized controlled trial
| 59 patients with CHD, on simvastatin 10-40 mg/d, with serum triglycerides > 2.3 mmol/l
| 1 year
| Omacor (84% omega-3 fatty acid) 2 g BD or placebo
|
*Decrease in serum [[triglycerides]] by 20-30% (p<0.005)
*Decrease in very low-density lipoprotein ([[VLDL]]) cholesterol by 30-40% (p<0.005)
|
* [[Omacor]] combination with [[simvastatin]] (concentrated source of [[omega-3 fatty acid]]s) was found to be a safe and effective in decreasing serum [[triglycerides]] level in a study over one year in [[coronary heart disease]] patients and [[hypertriglyceridemia]]
|-
===Study on effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia <ref name="pmid11303007">{{cite journal| author=Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA et al.| title=An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | journal=Heart | year= 2001 | volume= 85 | issue= 5 | pages= 544-8 | pmid=11303007 | doi= | pmc=PMC1729738 | url= }} </ref>===
===Study on effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia <ref name="pmid11303007">{{cite journal| author=Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA et al.| title=An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | journal=Heart | year= 2001 | volume= 85 | issue= 5 | pages= 544-8 | pmid=11303007 | doi= | pmc=PMC1729738 | url= }} </ref>===
* '''Source & year''' – Heart, 2001


* '''Study question''' – An omega-3 polyunsaturated fatty acid concentrate (Omacor) administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia


* '''Study Population and intervention''' – 59 patients with CHD, receiving simvastatin 10-40 mg daily with serum triglycerides > 2.3 mmol/l, were either given Omacor (84% omega-3 fatty acid) 2 g BD or placebo for 24 weeks


* '''Study design''' – Double blinded randomized controlled trial


* '''Study period''' – 1 year
 
 


* '''Study results''' – Combination of Simvastatin with Omacor compared with placebo or baseline resulted in:
* '''Study results''' – Combination of Simvastatin with Omacor compared with placebo or baseline resulted in:

Revision as of 15:32, 4 October 2011

Template:Hypertriglyceridemia

For full Omega-3 fatty acid drug info click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.[1][2][3].

Trial supportive data

Study on effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia [4]

External links

http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184

References

  1. ↑ "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
  2. ↑ Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
  3. ↑ "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".
  4. ↑ 4.0 4.1 Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA; et al. (2001). "An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia". Heart. 85 (5): 544–8. PMC 1729738. PMID 11303007.


Template:WikiDoc Sources

Study name Source & year Study question Study Design Study Population Time period Intervention Results Conclusions
Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia [4] Heart, 2001 To access the safety and efficacy of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia Double blinded randomized controlled trial 59 patients with CHD, on simvastatin 10-40 mg/d, with serum triglycerides > 2.3 mmol/l 1 year Omacor (84% omega-3 fatty acid) 2 g BD or placebo
  • Decrease in serum triglycerides by 20-30% (p<0.005)
  • Decrease in very low-density lipoprotein (VLDL) cholesterol by 30-40% (p<0.005)
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