Hereditary nonpolyposis colorectal cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Hereditary nonpolyposis colorectal cancer may be classified according to MSI-H into 3 subtypes: right-sided poorly differentiated cancers, right-sided mucinous cancers, and adenocarcinomas in any location showing any measurable level of intraepithelial lymphocyte (TIL). In addition, HNPCC can be divided into Lynch syndrome I (familial colon cancer) and Lynch syndrome II (HNPCC associated with other cancers of the gastrointestinal tract or reproductive system).

Classification

Lynch syndrome I (familial colon cancer)

• Site-specific colonic cancer

Lynch syndrome II

• Extracolonic cancer
• Includes extracolonic cancer, particularly carcinoma of the stomach, endometrium
• Associated condition, Muir-Torre syndrome

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