Hepatocellular adenoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

The most potent risk factor in the development of hepatocellular adenoma is use of oral contraceptive pills.[1]

Hepatocellular adenoma risk factors

  • The most potent risk factor in the development of hepatocellular adenoma is use of oral contraceptive pills.[1]
  • Hormonal dose
  • Duration of medication
  • Other risk factors include:[2]

Risk factors for malignant transformation

The risk factor for malignant transformation of hepatic adenoma to hepatocellular carcinoma is:[3]

  • Gender (men)
  • Size (> 8 cm)
  • Subtype (beta-catenin-activated HCA)

References

  1. 1.0 1.1 How do oral contraceptives affect liver cancer risk. National Cancer Institute 2015. http://www.cancer.gov/about-cancer/causes-prevention/risk/hormones/oral-contraceptives-fact-sheet
  2. 2.0 2.1 Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  3. Aamann L, Schultz N, Fallentin E, Hamilton-Dutoit S, Vogel I, Grønbæk H (2015). "[Hepatocellular adenoma - new classification and recommendations]". Ugeskr Laeger. 177 (12). PMID 25786843.


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