Hemolytic anemia resident survival guide
| Hemolytic anemia Resident Survival Guide |
|---|
| Overview |
| Causes |
| FIRE |
| Diagnosis |
| Treatment |
| Do's |
| Don'ts |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];
Overview
- Anemia is defined as a decrease in red blood cell population in the body.
- Hemolytic anemia results from a destruction of RBCs which is faster than the bone marrow production of them. Hemolysis can be due to either extravascular or intravascular destruction of cells[1].
- It is caused due to a wide variety of reasons which include inherited diseases like thalassemia, sickle cell disease etc, infections, autoimmune conditions, bone marrow dysfunction, blood transfusions and certain drugs can also result in hemolytic anemia [2].
- Most common presenting symptoms are fatigue, palpitations, dyspnea, tachycardia and icterus in severe cases.
- Diagnosis usually requires a battery of tests including, but not limited to a peripheral smear, CBC, serum LDH, bone marrow studies, etc.
- Treatment is directed by the specific cause and can involve bone marrow transplant, splenectomy, transfusions etc[3].
Causes
FIRE
Diagnosis
Treatment
Do's
Don'ts
References
- ↑ Phillips J, Henderson AC (2018). "Hemolytic Anemia: Evaluation and Differential Diagnosis". Am Fam Physician. 98 (6): 354–361. PMID 30215915.
- ↑ Renard D, Rosselet A (2017). "Drug-induced hemolytic anemia: Pharmacological aspects". Transfus Clin Biol. 24 (3): 110–114. doi:10.1016/j.tracli.2017.05.013. PMID 28648734.
- ↑ Morishita E (2015). "[Diagnosis and treatment of microangiopathic hemolytic anemia]". Rinsho Ketsueki. 56 (7): 795–806. doi:10.11406/rinketsu.56.795. PMID 26251142.