Hemolytic-uremic syndrome classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

HUS may be classified according etiology into 4 subtypes including diarrhoea-associated HUS, non-diarrhea-associated HUS (D−HUS), Streptococcus pneumoniae‐associated HUS, diacylglycerol kinase‐ε (DGKE)‐associated HUS.

Classification

Hemolytic-Uremic syndrome (HUS) may be classified as follows:

Typical Or Diarrhea Related

  • Shiga-Toxin producing E.Coli/ Shigella infection

Atypical or Non Diarrheal

Primary Causes

  • Complement Factor abnormalities
    • Factor H Defeciency (Autosomal Dominant)
    • Factor I Defeciency (Acquired antibody mediated)
    • Membrane co-factor protein Defeciency
    • Factor B Overactivity (Complement Factor B mutation)

References

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