Hamman-Rich syndrome natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, | If left untreated, patients with [[Hamman-Rich syndrome|acute interstitial pneumonitis]] have high [[fatality rate]] and die because of severe respiratory failure. Most of the survivors after initial [[hospitalization]] may develop recurrent [[disease]] or chronic [[lung]] fibrosis. [[Hamman-Rich syndrome|Acute interstitial pneumonitis]] usually has a very poor [[prognosis]]. | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
* | *[[Hamman-Rich syndrome|Acute interstitial pneumonitis]] has an [[Acute (medicine)|acute]] and severe onset, progresses very rapidly and have a high [[mortality rate]]. If left untreated, patients die because of [[respiratory failure]]. Survivors after initial hospitalization may develop recurrent disease or chronic lung fibrosis.<ref name="pmid16088688">{{cite journal |vauthors=Vourlekis JS, Brown KK, Schwarz MI |title=Acute interstitial pneumonitis: current understanding regarding diagnosis, pathogenesis, and natural history |journal=Semin Respir Crit Care Med |volume=22 |issue=4 |pages=399–408 |date=August 2001 |pmid=16088688 |doi=10.1055/s-2001-17383 |url=}}</ref> | ||
===Complications=== | ===Complications=== | ||
*Common complications of [ | *Common complications of [[Hamman-Rich syndrome|acute interstitial pneumonitis]] include:<ref name="pmid16172252">{{cite journal |vauthors=Matthay MA, Zimmerman GA |title=Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management |journal=Am. J. Respir. Cell Mol. Biol. |volume=33 |issue=4 |pages=319–27 |date=October 2005 |pmid=16172252 |pmc=2715340 |doi=10.1165/rcmb.F305 |url=}}</ref> | ||
**[ | **[[Respiratory failure]] and its complications | ||
**[ | ***[[Pulmonary embolism|Pulmonary emboli]] | ||
**[ | ***[[Barotrauma]] | ||
***[[Pneumonia]] | |||
***[[Gastrointestinal bleeding|Gastrointestinal hemorrhage]] | |||
***[[Renal insufficiency|Renal failure]] | |||
**Progressive [[Interstitial lung disease|pulmonary fibrosis]] | |||
===Prognosis=== | ===Prognosis=== | ||
*Prognosis of [[Hamman-Rich syndrome|acute interstitial pneumonitis]] is poor.<ref name="pmid19095855">{{cite journal |vauthors=Avnon LS, Pikovsky O, Sion-Vardy N, Almog Y |title=Acute interstitial pneumonia-Hamman-Rich syndrome: clinical characteristics and diagnostic and therapeutic considerations |journal=Anesth. Analg. |volume=108 |issue=1 |pages=232–7 |date=January 2009 |pmid=19095855 |doi=10.1213/ane.0b013e318188af7a |url=}}</ref><ref name="pmid17475632">{{cite journal |vauthors=Parambil JG, Myers JL, Aubry MC, Ryu JH |title=Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy |journal=Chest |volume=132 |issue=1 |pages=50–7 |date=July 2007 |pmid=17475632 |doi=10.1378/chest.07-0104 |url=}}</ref> | *Prognosis of [[Hamman-Rich syndrome|acute interstitial pneumonitis]] is poor.<ref name="pmid19095855">{{cite journal |vauthors=Avnon LS, Pikovsky O, Sion-Vardy N, Almog Y |title=Acute interstitial pneumonia-Hamman-Rich syndrome: clinical characteristics and diagnostic and therapeutic considerations |journal=Anesth. Analg. |volume=108 |issue=1 |pages=232–7 |date=January 2009 |pmid=19095855 |doi=10.1213/ane.0b013e318188af7a |url=}}</ref><ref name="pmid17475632">{{cite journal |vauthors=Parambil JG, Myers JL, Aubry MC, Ryu JH |title=Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy |journal=Chest |volume=132 |issue=1 |pages=50–7 |date=July 2007 |pmid=17475632 |doi=10.1378/chest.07-0104 |url=}}</ref> | ||
*Most patients die because of acute respiratory failure or its complications. | *Most patients die because of acute [[respiratory failure]] or its complications. | ||
*Mortality rate is very high, more than half of the patients die within 2 months. Patients who survive the initial hospitalization die within six months of presentation of disease. | *[[Mortality rate]] is very high, more than half of the patients die within 2 months. [[Patient|Patients]] who survive the initial [[hospitalization]] die within six months of presentation of disease. | ||
*Recurrence of the disease and progression to chronic interstitial lung disease can occur among survivors. | *Recurrence of the disease and progression to chronic [[interstitial lung disease]] can occur among survivors. | ||
==References== | ==References== | ||
Latest revision as of 00:25, 25 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
If left untreated, patients with acute interstitial pneumonitis have high fatality rate and die because of severe respiratory failure. Most of the survivors after initial hospitalization may develop recurrent disease or chronic lung fibrosis. Acute interstitial pneumonitis usually has a very poor prognosis.
Natural History, Complications, and Prognosis
Natural History
- Acute interstitial pneumonitis has an acute and severe onset, progresses very rapidly and have a high mortality rate. If left untreated, patients die because of respiratory failure. Survivors after initial hospitalization may develop recurrent disease or chronic lung fibrosis.[1]
Complications
- Common complications of acute interstitial pneumonitis include:[2]
- Respiratory failure and its complications
- Progressive pulmonary fibrosis
Prognosis
- Prognosis of acute interstitial pneumonitis is poor.[3][4]
- Most patients die because of acute respiratory failure or its complications.
- Mortality rate is very high, more than half of the patients die within 2 months. Patients who survive the initial hospitalization die within six months of presentation of disease.
- Recurrence of the disease and progression to chronic interstitial lung disease can occur among survivors.
References
- ↑ Vourlekis JS, Brown KK, Schwarz MI (August 2001). "Acute interstitial pneumonitis: current understanding regarding diagnosis, pathogenesis, and natural history". Semin Respir Crit Care Med. 22 (4): 399–408. doi:10.1055/s-2001-17383. PMID 16088688.
- ↑ Matthay MA, Zimmerman GA (October 2005). "Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management". Am. J. Respir. Cell Mol. Biol. 33 (4): 319–27. doi:10.1165/rcmb.F305. PMC 2715340. PMID 16172252.
- ↑ Avnon LS, Pikovsky O, Sion-Vardy N, Almog Y (January 2009). "Acute interstitial pneumonia-Hamman-Rich syndrome: clinical characteristics and diagnostic and therapeutic considerations". Anesth. Analg. 108 (1): 232–7. doi:10.1213/ane.0b013e318188af7a. PMID 19095855.
- ↑ Parambil JG, Myers JL, Aubry MC, Ryu JH (July 2007). "Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy". Chest. 132 (1): 50–7. doi:10.1378/chest.07-0104. PMID 17475632.