Hamartoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2] Vamsikrishna Gunnam M.B.B.S [3]

Overview

Hamartomas may be classified into different types based on their location, such as: lung (most common), heart, hypothalamus, kidneys, or spleen. Other classifications can consider lesion class, dividing hamartomas into 4 different categories, such as: bone-forming, cartilage-forming, fiber-forming, and benign non–matrix-forming.[1]

Classification

Location

Based on the location, hamartomas can be classified into the following types:[2]

Location Type
CNS
  • Hypothalamic hamartoma
  • Neurofibromatosis in von Recklinghausen disease
  • Neuroepithelial cells in tuberous sclerosis
Hypopharynx
  • Hypopharyngeal rhabdomyomatous
Lung
  • Endobronchial pulmonary hamartoma
  • Parenchymal pulmonary hamartoma
  • Bronchial hamartoma
Heart
  • Rhabdomyoma
Bowel
  • Peutz-Jeghers polyp
  • Polyp of the large bowel
Kidneys
  • Angiomyolipoma
Spleen
  • Splenic hamartoma
Skin
  • Melanocytic nevi

Lesion class

Based on the lesion class, hamartomas can be classified into the following types:

Lesion class Tumors type
Cartilage-forming
Fiber-forming
Bone-forming
Benign non-matrix-forming

References

  1. Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. Elsevier Health Sciences; 2012.
  2. Patterson HC, Dickerson GR, Pilch BZ, Bentkover SH (December 1981). "Hamartoma of the hypopharynx". Arch Otolaryngol. 107 (12): 767–72. PMID 7316862.


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