Melorheostosis

Jump to: navigation, search

WikiDoc Resources for Melorheostosis

Articles

Most recent articles on Melorheostosis

Most cited articles on Melorheostosis

Review articles on Melorheostosis

Articles on Melorheostosis in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Melorheostosis

Images of Melorheostosis

Photos of Melorheostosis

Podcasts & MP3s on Melorheostosis

Videos on Melorheostosis

Evidence Based Medicine

Cochrane Collaboration on Melorheostosis

Bandolier on Melorheostosis

TRIP on Melorheostosis

Clinical Trials

Ongoing Trials on Melorheostosis at Clinical Trials.gov

Trial results on Melorheostosis

Clinical Trials on Melorheostosis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Melorheostosis

NICE Guidance on Melorheostosis

NHS PRODIGY Guidance

FDA on Melorheostosis

CDC on Melorheostosis

Books

Books on Melorheostosis

News

Melorheostosis in the news

Be alerted to news on Melorheostosis

News trends on Melorheostosis

Commentary

Blogs on Melorheostosis

Definitions

Definitions of Melorheostosis

Patient Resources / Community

Patient resources on Melorheostosis

Discussion groups on Melorheostosis

Patient Handouts on Melorheostosis

Directions to Hospitals Treating Melorheostosis

Risk calculators and risk factors for Melorheostosis

Healthcare Provider Resources

Symptoms of Melorheostosis

Causes & Risk Factors for Melorheostosis

Diagnostic studies for Melorheostosis

Treatment of Melorheostosis

Continuing Medical Education (CME)

CME Programs on Melorheostosis

International

Melorheostosis en Espanol

Melorheostosis en Francais

Business

Melorheostosis in the Marketplace

Patents on Melorheostosis

Experimental / Informatics

List of terms related to Melorheostosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Melorheostosis is usually discovered in childhood, occasionally in adulthood. The male-to-female ratio is usually 1:1. It can occur in a single limb, and the lower extremity is more commonly affected than the upper extremity. The epicenter is periosteal or endosteal. The appearance consists of cortical hyperostosis in one or multiple bones, often with intervening soft-tissue calcification or ossification. The limb involved with melorheostosis often demonstrates joint pain, swelling, and limitation of motion in childhood. There is often associated growth disturbance, muscular contraction, and limb length discrepancy. There may be overlying skin changes. At pathologic analysis, thickened and enlarged osseous trabeculae are noted, associated with fibrous tissue replacement of the marrow space. There is controversy involving the distribution of melorheostosis. It has been suggested that the distribution mimics that of the sclerotomes (zones supplied by individual spinal sensory nerves), implying a neurogenic origin.

Diagnosis

The imaging findings are

  • At radiography, contiguous bones of an extremity are often involved, although there may be involvement of a single bone.
  • There is cortical hyperostosis with intervening soft-tissue calcification or ossification. Dripping candle wax appearance.
  • There may be endosteal hyperostosis with obliteration of the medullary space.

References



Linked-in.jpg