HSPA2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Heat shock-related 70 kDa protein 2''' is a [[protein]] that in humans is encoded by the ''HSPA2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HSPA2 heat shock 70kDa protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3306| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HSPA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hpm.
| PDB = {{PDB2|1hpm}}, {{PDB2|1hx1}}, {{PDB2|1kax}}, {{PDB2|1kay}}, {{PDB2|1kaz}}, {{PDB2|1ngi}}, {{PDB2|1ngj}}, {{PDB2|1qqo}}, {{PDB2|2bup}}, {{PDB2|3hsc}}
| Name = Heat shock 70kDa protein 2
| HGNCid = 5235
| Symbol = HSPA2
| AltSymbols =;
| OMIM = 140560
| ECnumber = 
| Homologene = 68564
| MGIid = 96243
| GeneAtlas_image1 = PBB_GE_HSPA2_211538_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0009986 |text = cell surface}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}} {{GNF_GO|id=GO:0007140 |text = male meiosis}} {{GNF_GO|id=GO:0007286 |text = spermatid development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3306
    | Hs_Ensembl = ENSG00000126803
    | Hs_RefseqProtein = NP_068814
    | Hs_RefseqmRNA = NM_021979
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 64077213
    | Hs_GenLoc_end = 64079703
    | Hs_Uniprot = P54652
    | Mm_EntrezGene = 15512
    | Mm_Ensembl = ENSMUSG00000059970
    | Mm_RefseqmRNA = NM_001002012
    | Mm_RefseqProtein = NP_001002012
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 77323016
    | Mm_GenLoc_end = 77325778
    | Mm_Uniprot = Q99KD7
  }}
}}
'''Heat shock 70kDa protein 2''', also known as '''HSPA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HSPA2 heat shock 70kDa protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3306| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schwab CG, Bozak CK, Whitehouse NL, Olson VM |title=Amino acid limitation and flow to the duodenum at four stages of lactation. 2. Extent of lysine limitation. |journal=J. Dairy Sci. |volume=75 |issue= 12 |pages= 3503-18 |year= 1993 |pmid= 1474216 |doi=  }}
*{{cite journal  |vauthors=Schwab CG, Bozak CK, Whitehouse NL, Olson VM |title=Amino acid limitation and flow to the duodenum at four stages of lactation. 2. Extent of lysine limitation. |journal=J. Dairy Sci. |volume=75 |issue= 12 |pages= 3503–18 |year= 1993 |pmid= 1474216 |doi=10.3168/jds.S0022-0302(92)78126-0 }}
*{{cite journal  | author=Dworniczak B, Mirault ME |title=Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. |journal=Nucleic Acids Res. |volume=15 |issue= 13 |pages= 5181-97 |year= 1987 |pmid= 3037489 |doi=  }}
*{{cite journal  |vauthors=Dworniczak B, Mirault ME |title=Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. |journal=Nucleic Acids Res. |volume=15 |issue= 13 |pages= 5181–97 |year= 1987 |pmid= 3037489 |doi=10.1093/nar/15.13.5181  | pmc=305955 }}
*{{cite journal | author=Bonnycastle LL, Yu CE, Hunt CR, ''et al.'' |title=Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). |journal=Genomics |volume=23 |issue= 1 |pages= 85-93 |year= 1995 |pmid= 7829106 |doi= 10.1006/geno.1994.1462 }}
*{{cite journal   |vauthors=Bonnycastle LL, Yu CE, Hunt CR, etal |title=Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). |journal=Genomics |volume=23 |issue= 1 |pages= 85–93 |year= 1995 |pmid= 7829106 |doi= 10.1006/geno.1994.1462 }}
*{{cite journal  | author=Roux AF, Nguyen VT, Squire JA, Cox DW |title=A heat shock gene at 14q22: mapping and expression. |journal=Hum. Mol. Genet. |volume=3 |issue= 10 |pages= 1819-22 |year= 1995 |pmid= 7849706 |doi=  }}
*{{cite journal  |vauthors=Roux AF, Nguyen VT, Squire JA, Cox DW |title=A heat shock gene at 14q22: mapping and expression. |journal=Hum. Mol. Genet. |volume=3 |issue= 10 |pages= 1819–22 |year= 1995 |pmid= 7849706 |doi=10.1093/hmg/3.10.1819 }}
*{{cite journal | author=Furlini G, Vignoli M, Re MC, ''et al.'' |title=Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein. |journal=J. Gen. Virol. |volume=75 ( Pt 1) |issue= |pages= 193-9 |year= 1994 |pmid= 7906708 |doi=  }}
*{{cite journal   |vauthors=Furlini G, Vignoli M, Re MC, etal |title=Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein. |journal=J. Gen. Virol. |volume=75 | issue = 1 |pages= 193–9 |year= 1994 |pmid= 7906708 |doi=10.1099/0022-1317-75-1-193 }}
*{{cite journal | author=Allen JW, Dix DJ, Collins BW, ''et al.'' |title=HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes. |journal=Chromosoma |volume=104 |issue= 6 |pages= 414-21 |year= 1996 |pmid= 8601336 |doi=  }}
*{{cite journal   |vauthors=Allen JW, Dix DJ, Collins BW, etal |title=HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes. |journal=Chromosoma |volume=104 |issue= 6 |pages= 414–21 |year= 1996 |pmid= 8601336 |doi=10.1007/BF00352265 }}
*{{cite journal | author=Dix DJ, Allen JW, Collins BW, ''et al.'' |title=Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3264-8 |year= 1996 |pmid= 8622925 |doi=  }}
*{{cite journal   |vauthors=Dix DJ, Allen JW, Collins BW, etal |title=Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3264–8 |year= 1996 |pmid= 8622925 |doi=10.1073/pnas.93.8.3264  | pmc=39594 }}
*{{cite journal  | author=Zhu D, Dix DJ, Eddy EM |title=HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes. |journal=Development |volume=124 |issue= 15 |pages= 3007-14 |year= 1997 |pmid= 9247342 |doi=  }}
*{{cite journal  |vauthors=Zhu D, Dix DJ, Eddy EM |title=HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes. |journal=Development |volume=124 |issue= 15 |pages= 3007–14 |year= 1997 |pmid= 9247342 |doi=  }}
*{{cite journal | author=O'Keeffe B, Fong Y, Chen D, ''et al.'' |title=Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 279-87 |year= 2000 |pmid= 10617616 |doi=  }}
*{{cite journal   |vauthors=O'Keeffe B, Fong Y, Chen D, etal |title=Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 279–87 |year= 2000 |pmid= 10617616 |doi=10.1074/jbc.275.1.279 }}
*{{cite journal | author=Agostini I, Popov S, Li J, ''et al.'' |title=Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex. |journal=Exp. Cell Res. |volume=259 |issue= 2 |pages= 398-403 |year= 2000 |pmid= 10964507 |doi= 10.1006/excr.2000.4992 }}
*{{cite journal   |vauthors=Agostini I, Popov S, Li J, etal |title=Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex. |journal=Exp. Cell Res. |volume=259 |issue= 2 |pages= 398–403 |year= 2000 |pmid= 10964507 |doi= 10.1006/excr.2000.4992 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
*{{cite journal  | author=Gurer C, Cimarelli A, Luban J |title=Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. |journal=J. Virol. |volume=76 |issue= 9 |pages= 4666-70 |year= 2002 |pmid= 11932435 |doi= }}
*{{cite journal  |vauthors=Gurer C, Cimarelli A, Luban J |title=Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. |journal=J. Virol. |volume=76 |issue= 9 |pages= 4666–70 |year= 2002 |pmid= 11932435 |doi=10.1128/JVI.76.9.4666-4670.2002  | pmc=155079  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Shin BK, Wang H, Yim AM, ''et al.'' |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607-16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200 }}
*{{cite journal   |vauthors=Shin BK, Wang H, Yim AM, etal |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607–16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200 }}
*{{cite journal  | author=Lim MC, Brooke SM, Sapolsky RM |title=gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120. |journal=Brain Res. Bull. |volume=61 |issue= 2 |pages= 183-8 |year= 2003 |pmid= 12832005 |doi=  }}
*{{cite journal  |vauthors=Lim MC, Brooke SM, Sapolsky RM |title=gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120. |journal=Brain Res. Bull. |volume=61 |issue= 2 |pages= 183–8 |year= 2003 |pmid= 12832005 |doi=10.1016/S0361-9230(03)00113-8 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3306}}
== External links ==
* {{MeshName|HSPA2+protein,+human}}
{{Chaperones}}
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[[Category:Heat shock proteins]]


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Latest revision as of 14:06, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heat shock-related 70 kDa protein 2 is a protein that in humans is encoded by the HSPA2 gene.[1]


References

  1. ↑ "Entrez Gene: HSPA2 heat shock 70kDa protein 2".

Further reading

External links


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