HAS3

Hyaluronan synthase 3
Identifiers
Symbols	HAS3 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68461
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hyaluronan synthase 3, also known as HAS3, is a human gene.

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Spicer AP, Olson JS, McDonald JA (1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J. Biol. Chem. 272 (14): 8957–61. PMID 9083017.CS1 maint: Multiple names: authors list (link)
• Spicer AP, Seldin MF, Olsen AS; et al. (1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jacobson A, Brinck J, Briskin MJ; et al. (2000). "Expression of human hyaluronan synthases in response to external stimuli". Biochem. J. 348 Pt 1: 29–35. PMID 10794710.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson MA, Reiland J, Burger SR; et al. (2001). "Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells". J. Biol. Chem. 276 (21): 17949–57. doi:10.1074/jbc.M010064200. PMID 11278609.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuroda K, Utani A, Hamasaki Y, Shinkai H (2001). "Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts". J. Dermatol. Sci. 26 (2): 156–60. PMID 11378333.CS1 maint: Multiple names: authors list (link)
• Liu N, Gao F, Han Z; et al. (2001). "Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells". Cancer Res. 61 (13): 5207–14. PMID 11431361.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson MA, Wilson CM, Furcht LT; et al. (2002). "Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells". J. Biol. Chem. 277 (12): 10050–7. doi:10.1074/jbc.M110069200. PMID 11790779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sayo T, Sugiyama Y, Takahashi Y; et al. (2002). "Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes". J. Invest. Dermatol. 118 (1): 43–8. doi:10.1046/j.0022-202x.2001.01613.x. PMID 11851874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chagnon P, Michaud J, Mitchell G; et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. PMID 12417987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bullard KM, Kim HR, Wheeler MA; et al. (2004). "Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth". Int. J. Cancer. 107 (5): 739–46. doi:10.1002/ijc.11475. PMID 14566823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki K, Yamamoto T, Usui T; et al. (2004). "Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta". Jpn. J. Ophthalmol. 47 (6): 557–64. PMID 14636845.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). "Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells". Biochim. Biophys. Acta. 1760 (6): 890–5. doi:10.1016/j.bbagen.2006.02.002. PMID 16564133.CS1 maint: Multiple names: authors list (link)
• Campo GM, Avenoso A, Campo S; et al. (2007). "TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate". Mol. Cell. Biochem. 292 (1–2): 169–78. doi:10.1007/s11010-006-9230-7. PMID 16786194.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)