Graft-versus-host disease: Difference between revisions

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{{Graft-versus-host disease}}
{{Graft-versus-host disease}}


{{CMG}}
{{CMG}} {{shyam}}


{{SK}} GVHD
{{SK}} GVHD
==[[Graft-versus-host disease patient information|Patient Information]]==


==[[Graft-versus-host disease overview|Overview]]==
==[[Graft-versus-host disease overview|Overview]]==
Graft-versus-host disease (GvHD) is a condition characterized by recipient tissue damage that arise from immunological activation of donor T lymphocytes. It typically occurs in the setting of bone marrow transplantation. Donor T cells mount a response against foreign host cells in the gastrointestinal system, liver, and skin.


==[[Graft-versus-host disease historical perspective|Historical Perspective]]==
==[[Graft-versus-host disease historical perspective|Historical Perspective]]==
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==Diagnosis==
==Diagnosis==
 
[[Graft-versus-host disease diagnostic study of choice|Diagnostic Study of Choice]]
[[Graft-versus-host disease history and symptoms|History and Symptoms]]
| [[Graft-versus-host disease history and symptoms|History and Symptoms]]
| [[Graft-versus-host disease physical examination|Physical Examination]]
| [[Graft-versus-host disease physical examination|Physical Examination]]
| [[Graft-versus-host disease laboratory findings|Laboratory Findings]]
| [[Graft-versus-host disease laboratory findings|Laboratory Findings]]
| [[Graft-versus-host disease electrocardiogram|Electrocardiogram]]
| [[Graft-versus-host disease chest x ray|Chest X Ray]]
| [[Graft-versus-host disease chest x ray|Chest X Ray]]
| [[Graft-versus-host disease echocardiograph and ultrasound|Echocardiograph and Ultrasound]]
| [[Graft-versus-host disease CT|CT]]
| [[Graft-versus-host disease CT|CT]]
| [[Graft-versus-host disease mri|MRI]]
| [[Graft-versus-host disease other imaging findings|Other Imaging Findings]]
| [[Graft-versus-host disease other imaging findings|Other Imaging Findings]]
| [[Graft-versus-host disease other diagnostic studies|Other Diagnostic Studies]]
| [[Graft-versus-host disease other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==
 
| [[Graft-versus-host disease medical therapy|Medical Therapy]]
[[Graft-versus-host disease medical therapy
| [[Graft-versus-host disease surgery|Surgery]]
|Medical Therapy]]
 
The treatment of GvHD focuses on immunosuppression. Immunosuppression is usually achieved by administering steroids, auch as prednisone or methylprednisolone.<ref name="pmid17784964">{{cite journal| author=Jacobsohn DA, Vogelsang GB| title=Acute graft versus host disease. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 35 | pmid=17784964 | doi=10.1186/1750-1172-2-35 | pmc=2018687 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17784964  }} </ref> Alternative agents include immunophilins like cyclosporine or tacrolimus.<ref name="pmid17784964">{{cite journal| author=Jacobsohn DA, Vogelsang GB| title=Acute graft versus host disease. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 35 | pmid=17784964 | doi=10.1186/1750-1172-2-35 | pmc=2018687 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17784964  }} </ref> Ruxolitinib has been used for GvHD that is refractory to steroids.<ref name="pmid28444730">{{cite journal| author=Assouan D, Lebon D, Charbonnier A, Royer B, Marolleau JP, Gruson B| title=Ruxolitinib as a promising treatment for corticosteroid-refractory graft-versus-host disease. | journal=Br J Haematol | year= 2017 | volume=  | issue=  | pages=  | pmid=28444730 | doi=10.1111/bjh.14679 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28444730  }} </ref>
 
| [[Graft-versus-host disease primary prevention|Primary Prevention]]
| [[Graft-versus-host disease primary prevention|Primary Prevention]]
| [[Graft-versus-host disease secondary prevention|Secondary Prevention]]
| [[Graft-versus-host disease secondary prevention|Secondary Prevention]]
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* [[Immunosuppression]]
* [[Immunosuppression]]


[[Category:Primary care]]
 
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Immunology]]
[[Category:Immunology]]

Latest revision as of 06:34, 28 July 2020

Graft-versus-host disease

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]

Synonyms and keywords: GVHD

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Graft-versus-host disease from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

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