Gonadoblastoma laboratory findings: Difference between revisions
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{{Gonadoblastoma}} | {{Gonadoblastoma}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{Sahar}} | ||
==Overview== | ==Overview== | ||
Gonadoblastoma has no specific laboratory feature, however, some immunohistochemistry staining can be positive. Some patients with gonadoblastoma may have elevated concentration of [[human chorionic gonadotropin]] (hCG), which is usually suggestive of [[dysgerminoma]]. | |||
Some patients with | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
Gonadoblastoma has no specific laboratory feature, however, some immunohistochemistry staining can be positive including:<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref><ref name="KaoUlbright2014">{{cite journal|last1=Kao|first1=Chia-Sui|last2=Ulbright|first2=Thomas M|last3=Idrees|first3=Muhammad T|title=Gonadoblastoma: an immunohistochemical study and comparison to Sertoli cell nodule with intratubular germ cell neoplasia, with pathogenetic implications|journal=Histopathology|volume=65|issue=6|year=2014|pages=861–867|issn=03090167|doi=10.1111/his.12444}}</ref><ref name="EsinBaser2011">{{cite journal|last1=Esin|first1=Sertac|last2=Baser|first2=Eralp|last3=Kucukozkan|first3=Tuncay|last4=Magden|first4=Hasim Ata|title=Ovarian gonadoblastoma with dysgerminoma in a 15-year-old girl with 46, XX karyotype: case report and review of the literature|journal=Archives of Gynecology and Obstetrics|volume=285|issue=2|year=2011|pages=447–451|issn=0932-0067|doi=10.1007/s00404-011-2073-9}}</ref> | |||
*TSPY | |||
*OCT3/4 | |||
*FoxL | |||
*SF-1 | |||
*Sox9 | |||
Some patients with gonadoblastoma may have elevated concentration of [[human chorionic gonadotropin]] (hCG), which is usually suggestive of [[dysgerminoma]]. | |||
* | |||
* | |||
* | |||
Some patients with | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 16:38, 14 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Gonadoblastoma has no specific laboratory feature, however, some immunohistochemistry staining can be positive. Some patients with gonadoblastoma may have elevated concentration of human chorionic gonadotropin (hCG), which is usually suggestive of dysgerminoma.
Laboratory Findings
Gonadoblastoma has no specific laboratory feature, however, some immunohistochemistry staining can be positive including:[1][2][3]
- TSPY
- OCT3/4
- FoxL
- SF-1
- Sox9
Some patients with gonadoblastoma may have elevated concentration of human chorionic gonadotropin (hCG), which is usually suggestive of dysgerminoma.
References
- ↑ Sperling, M (2014). Pediatric endocrinology. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-4858-7.
- ↑ Kao, Chia-Sui; Ulbright, Thomas M; Idrees, Muhammad T (2014). "Gonadoblastoma: an immunohistochemical study and comparison to Sertoli cell nodule with intratubular germ cell neoplasia, with pathogenetic implications". Histopathology. 65 (6): 861–867. doi:10.1111/his.12444. ISSN 0309-0167.
- ↑ Esin, Sertac; Baser, Eralp; Kucukozkan, Tuncay; Magden, Hasim Ata (2011). "Ovarian gonadoblastoma with dysgerminoma in a 15-year-old girl with 46, XX karyotype: case report and review of the literature". Archives of Gynecology and Obstetrics. 285 (2): 447–451. doi:10.1007/s00404-011-2073-9. ISSN 0932-0067.