Gliomatosis cerebri classification: Difference between revisions

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*Median age at diagnosis is 56 years
*Median age at diagnosis is 56 years
*Mean survival time was longer (24 months)
*Mean survival time was longer (24 months)
*Low-grade tumor is more common
*Predominantly low-grade
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*Median age at diagnosis is 44 years
*Median age at diagnosis is 44 years
*Mean survival time was shorter (21 months)
*Mean survival time was shorter (21 months)
*High-grade tumor is more common
*Predominantly high-grade
*''IDH1'' mutation is more common
*''IDH1'' mutation is more common
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Revision as of 23:42, 1 October 2015

Gliomatosis cerebri Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Classification

1. Based on the origin

Gliomatosis cerebri may be classified based on the origin into two subtypes:[1][2] [3]

Type of gliomatosis cerebri Characteristic features

Type 1 (Primary)

  • No pre-existing primary cerebral neoplastic lesion (de novo)
  • No discrete mass
  • Diffuse spread of tumor
  • More common
  • Median age at diagnosis is 56 years
  • Mean survival time was longer (24 months)
  • Predominantly low-grade

Type 2 (Secondary)

  • Results from a pre-existing cerebral glioma
  • Discrete mass with diffuse CNS involvement
  • Less common
  • Median age at diagnosis is 44 years
  • Mean survival time was shorter (21 months)
  • Predominantly high-grade
  • IDH1 mutation is more common

2. Based on the type of tumor cell

Gliomatosis cerebri may be classified based on the predominant tumor cell type into three subtypes:[4]

References

  1. Classification of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
  2. Brandão RA, de Carvalho GT, de Azeredo Coutinho CA, Christo PP, Santiago CF, Santos Mdo C; et al. (2011). "Gliomatosis cerebri: diagnostic considerations in three cases". Neurol India. 59 (1): 122–5. doi:10.4103/0028-3886.76892. PMID 21339680.
  3. Park S, Suh YL, Nam DH, Kim ST (2009). "Gliomatosis cerebri: clinicopathologic study of 33 cases and comparison of mass forming and diffuse types". Clin Neuropathol. 28 (2): 73–82. PMID 19353837.
  4. Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J; et al. (2004). "Initial chemotherapy in gliomatosis cerebri". Neurology. 63 (2): 270–5. PMID 15277619.


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