Gliomatosis cerebri classification

Jump to navigation Jump to search

Gliomatosis cerebri Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gliomatosis cerebri from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Gliomatosis cerebri classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Gliomatosis cerebri classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Gliomatosis cerebri classification

CDC on Gliomatosis cerebri classification

Gliomatosis cerebri classification in the news

Blogs on Gliomatosis cerebri classification

Directions to Hospitals Treating Gliomatosis cerebri

Risk calculators and risk factors for Gliomatosis cerebri classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Gliomatosis cerebri may be classified into several subtypes based on the origin (primary and secondary) and the type of tumor cell (astrocytic, oligodendroglial, and mixed).

Classification

Based on the origin

Gliomatosis cerebri may be classified based on the origin into two subtypes:[1][2][3][4]

Type of gliomatosis cerebri Characteristic features

Type 1 (Primary)

  • No pre-existing primary cerebral neoplastic lesion (de novo)
  • No discrete mass
  • Diffuse spread of tumor
  • More common
  • Median age at diagnosis is 56 years
  • Mean survival time was longer than type 2 (24 months)
  • Predominantly low-grade

Type 2 (Secondary)

  • Results from a pre-existing cerebral glioma
  • Discrete mass with diffuse CNS involvement
  • Less common
  • Median age at diagnosis is 44 years
  • Mean survival time was shorter than type 1 (21 months)
  • Predominantly high-grade
  • IDH1 mutation is more common

Based on the type of tumor cell

Gliomatosis cerebri may be classified based on the predominant tumor cell type into three sub-types:[4]

  • Astrocytic - it is considered a distinct entity of astrocytic glioma as per the latest WHO classification for CNS tumors.[5]
  • Oligodendroglial - very few cases of isolated oligodendroglial GC has been reported. No difference in the signs and symptoms are noted.[6]
  • Mixed - more common than isolated oligodendroglial GC.

References

  1. Classification of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
  2. Brandão RA, de Carvalho GT, de Azeredo Coutinho CA, Christo PP, Santiago CF, Santos Mdo C; et al. (2011). "Gliomatosis cerebri: diagnostic considerations in three cases". Neurol India. 59 (1): 122–5. doi:10.4103/0028-3886.76892. PMID 21339680.
  3. Park S, Suh YL, Nam DH, Kim ST (2009). "Gliomatosis cerebri: clinicopathologic study of 33 cases and comparison of mass forming and diffuse types". Clin Neuropathol. 28 (2): 73–82. PMID 19353837.
  4. 4.0 4.1 Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J; et al. (2004). "Initial chemotherapy in gliomatosis cerebri". Neurology. 63 (2): 270–5. PMID 15277619.
  5. "Gliomatosis cerebri: no evidence for a separate brain tumor entity".
  6. "Oligodendroglial gliomatosis cerebri".


Template:WikiDoc Sources