Gliomatosis cerebri classification: Difference between revisions

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==Overview==
==Overview==
Gliomatosis cerebri may be classified into several subtypes based on the origin (primary and secondary) and the type of tumor cell ([[astrocyte|astrocytic]], [[oligodendrocyte|oligodendroglial]], and mixed).


==Classification==
==Classification==
Gliomatosis cerebri may be classified into two subtypes:<ref name=aaa>Classification of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri</ref><ref name="pmid21339680">{{cite journal| author=Brandão RA, de Carvalho GT, de Azeredo Coutinho CA, Christo PP, Santiago CF, Santos Mdo C et al.| title=Gliomatosis cerebri: diagnostic considerations in three cases. | journal=Neurol India | year= 2011 | volume= 59 | issue= 1 | pages= 122-5 | pmid=21339680 | doi=10.4103/0028-3886.76892 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21339680  }} </ref>  
 
=== Based on the origin ===
Gliomatosis cerebri may be classified based on the origin into two subtypes:<ref name="aaa">Classification of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri</ref><ref name="pmid21339680">{{cite journal| author=Brandão RA, de Carvalho GT, de Azeredo Coutinho CA, Christo PP, Santiago CF, Santos Mdo C et al.| title=Gliomatosis cerebri: diagnostic considerations in three cases. | journal=Neurol India | year= 2011 | volume= 59 | issue= 1 | pages= 122-5 | pmid=21339680 | doi=10.4103/0028-3886.76892 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21339680 }} </ref><ref name="pmid19353837">{{cite journal| author=Park S, Suh YL, Nam DH, Kim ST| title=Gliomatosis cerebri: clinicopathologic study of 33 cases and comparison of mass forming and diffuse types. | journal=Clin Neuropathol | year= 2009 | volume= 28 | issue= 2 | pages= 73-82 | pmid=19353837 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19353837  }} </ref><ref name="pmid15277619">{{cite journal| author=Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J et al.| title=Initial chemotherapy in gliomatosis cerebri. | journal=Neurology | year= 2004 | volume= 63 | issue= 2 | pages= 270-5 | pmid=15277619 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15277619 }} </ref>


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{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
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! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Characteristic features}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Characteristic features}}
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
! style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
Type 1 (Primary)
Type 1 (Primary)
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*No pre-existing primary cerebral neoplastic lesion (''de novo'')
*No discrete mass
*No discrete mass
*No pre-existing primary cerebral neoplastic lesion
*Diffuse spread of tumor
*More common  
*More common
*Median age at diagnosis is 56 years
*Mean survival time was longer than type 2 (24 months)
*Predominantly low-grade
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
! style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
Type 2 (Secondary)
Type 2 (Secondary)
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Results from a pre-existing cerebral glioma
*Discrete mass with diffuse [[CNS]] involvement
*Discrete mass with diffuse [[CNS]] involvement
*Pre-existing cerebral neoplasm progress and infiltrate other cerebral lobes.
*Less common
*Less common
*''IDH1'' mutation is more common in this subtype
*Median age at diagnosis is 44 years
*Mean survival time was shorter than type 1 (21 months)
*Predominantly high-grade
*''IDH1'' mutation is more common
|}
|}
===Based on the type of tumor cell===
Gliomatosis cerebri may be classified based on the predominant tumor cell type into three sub-types:<ref name="pmid15277619">{{cite journal| author=Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J et al.| title=Initial chemotherapy in gliomatosis cerebri. | journal=Neurology | year= 2004 | volume= 63 | issue= 2 | pages= 270-5 | pmid=15277619 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15277619  }} </ref>
*[[astrocyte|Astrocytic]] - it is considered a distinct entity of astrocytic glioma as per the latest WHO classification for CNS tumors.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pubmed/26493382|title=Gliomatosis cerebri: no evidence for a separate brain tumor entity|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>
*[[oligodendrocyte|Oligodendroglial]] - very few cases of isolated oligodendroglial GC has been reported. No difference in the signs and symptoms are noted.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/pubmed/1592395|title=Oligodendroglial gliomatosis cerebri|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>
*Mixed - more common than isolated oligodendroglial GC.


==References==
==References==
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Latest revision as of 16:17, 7 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Gliomatosis cerebri may be classified into several subtypes based on the origin (primary and secondary) and the type of tumor cell (astrocytic, oligodendroglial, and mixed).

Classification

Based on the origin

Gliomatosis cerebri may be classified based on the origin into two subtypes:[1][2][3][4]

Type of gliomatosis cerebri Characteristic features

Type 1 (Primary)

  • No pre-existing primary cerebral neoplastic lesion (de novo)
  • No discrete mass
  • Diffuse spread of tumor
  • More common
  • Median age at diagnosis is 56 years
  • Mean survival time was longer than type 2 (24 months)
  • Predominantly low-grade

Type 2 (Secondary)

  • Results from a pre-existing cerebral glioma
  • Discrete mass with diffuse CNS involvement
  • Less common
  • Median age at diagnosis is 44 years
  • Mean survival time was shorter than type 1 (21 months)
  • Predominantly high-grade
  • IDH1 mutation is more common

Based on the type of tumor cell

Gliomatosis cerebri may be classified based on the predominant tumor cell type into three sub-types:[4]

  • Astrocytic - it is considered a distinct entity of astrocytic glioma as per the latest WHO classification for CNS tumors.[5]
  • Oligodendroglial - very few cases of isolated oligodendroglial GC has been reported. No difference in the signs and symptoms are noted.[6]
  • Mixed - more common than isolated oligodendroglial GC.

References

  1. ↑ Classification of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
  2. ↑ Brandão RA, de Carvalho GT, de Azeredo Coutinho CA, Christo PP, Santiago CF, Santos Mdo C; et al. (2011). "Gliomatosis cerebri: diagnostic considerations in three cases". Neurol India. 59 (1): 122–5. doi:10.4103/0028-3886.76892. PMID 21339680.
  3. ↑ Park S, Suh YL, Nam DH, Kim ST (2009). "Gliomatosis cerebri: clinicopathologic study of 33 cases and comparison of mass forming and diffuse types". Clin Neuropathol. 28 (2): 73–82. PMID 19353837.
  4. ↑ 4.0 4.1 Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J; et al. (2004). "Initial chemotherapy in gliomatosis cerebri". Neurology. 63 (2): 270–5. PMID 15277619.
  5. ↑ "Gliomatosis cerebri: no evidence for a separate brain tumor entity".
  6. ↑ "Oligodendroglial gliomatosis cerebri".


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