Glioblastoma multiforme differential diagnosis

Glioblastoma multiforme Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Glioblastoma multiforme from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Glioblastoma multiforme differential diagnosis On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Glioblastoma multiforme differential diagnosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Glioblastoma multiforme differential diagnosis
CDC on Glioblastoma multiforme differential diagnosis
Glioblastoma multiforme differential diagnosis in the news
Blogs on Glioblastoma multiforme differential diagnosis
Directions to Hospitals Treating Glioblastoma multiforme
Risk calculators and risk factors for Glioblastoma multiforme differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Glioblastoma multiforme must be differentiated from cerebral metastasis, primary CNS lymphoma, cerebral abscess, anaplastic astrocytoma, tumefactive demyelination, stroke, cerebral toxoplasmosis, radiation necrosis, encephalitis, oligodendroglioma, and epilepsy.

Differentiating Glioblastoma multiforme from other Diseases

Glioblastoma multiforme must be differentiated from the following:

Differential diagnosis	Characteristic features of the differential diagnosis
Cerebral metastasis	May look identical Both may appear multifocal Metastases are centred on grey-white matter junction and spare the overlying cortex
Primary CNS lymphoma	In patients with AIDS Central necrosis is more common Homogeneously enhancing on MRI
Cerebral abscess	Central restricted diffusion is helpful Hemorrhagic then assessment may be difficult Presence of smooth and complete SWI low intensity rim Presence of dual rim sign
Anaplastic astrocytoma	No central necrosis
Tumefactive demyelination	Can appear similar Open ring pattern of enhancement Younger patients
Stroke	History is suggestive of diagnosis No elevated choline
Cerebral toxoplasmosis	In patients with AIDS
Radiation necrosis	History of radiation exposure
Encephalitis	History of fever Confusion Stiff neck may be present suggestive of meningoencephalitis
Oligodendroglioma	Biopsy helps in differentiation Slower growing tumor Better prognosis
Epilepsy	Multifactorial Mass may or may not be observed on MRI depending on the cause

References

Template:WikiDoc Sources