Glioblastoma multiforme differential diagnosis: Difference between revisions

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:[[Cerebral metastasis]]
:Cerebral [[metastasis]]
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*May look identical
*May look identical
*Both may appear multifocal
*Both may appear multifocal
*Metastases are centred on grey-white matter junction and spare the overlying cortex
*Metastases are centred on [[grey-white matter]] junction and spare the overlying [[cortex]]
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:Primary CNS lymphoma
:[[Primary CNS lymphoma]]
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*Seen in patients with AIDS
*In patients with [[AIDS]]
*Central necrosis is more common
*[[Central necrosis]] is more common
*Homogeneously enhancing on MRI  
*Homogeneously enhancing on [[MRI]]
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:Cerebral abscess
:[[Cerebral abscess]]
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*Central restricted diffusion is helpful
*Central restricted diffusion is helpful
*Hemorrhagic then assessment may be difficult  
*[[Hemorrhagic]] then assessment may be difficult  
*Presence of smooth and complete SWI low intensity rim
*Presence of smooth and complete SWI low intensity rim
*Presence of dual rim sign
*Presence of dual rim sign
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:Anaplastic astrocytoma
:[[Anaplastic astrocytoma]]
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*No central necrosis
*No central [[necrosis]]
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:Tumefactive demyelination
:[[Tumefactive demyelination]]
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*Can appear similar
*Can appear similar
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:Stroke
:[[Stroke]]
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*History is suggestive of diagnosis
*History is suggestive of diagnosis
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:Cerebral toxoplasmosis
:[[Cerebral toxoplasmosis]]
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*Seen in patients with AIDS
*Seen in patients with [[AIDS]]
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:Radiation necrosis
:[[Radiation necrosis]]
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*Positive history of radiation
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:Encephalitis
:[[Encephalitis]]
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:Oligodendroglioma
:[[Oligodendroglioma]]
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:Seizures
:[[Epilepsy]]
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Revision as of 14:37, 14 September 2015

Glioblastoma multiforme Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Differentiating Glioblastoma multiforme from other Diseases

Glioblastoma must be differentiated from:[1]

Differential diagnosis Characteristic features
Cerebral metastasis
  • May look identical
  • Both may appear multifocal
  • Metastases are centred on grey-white matter junction and spare the overlying cortex
Primary CNS lymphoma
Cerebral abscess
  • Central restricted diffusion is helpful
  • Hemorrhagic then assessment may be difficult
  • Presence of smooth and complete SWI low intensity rim
  • Presence of dual rim sign
Anaplastic astrocytoma
Tumefactive demyelination
  • Can appear similar
  • Open ring pattern of enhancement
  • Younger patients
Stroke
  • History is suggestive of diagnosis
  • No elevated choline
Cerebral toxoplasmosis
  • Seen in patients with AIDS
Radiation necrosis
  • Positive history of radiation
Encephalitis
Oligodendroglioma
Epilepsy

References

  1. DDx of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma


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