Glanzmann's thrombasthenia history and symptoms: Difference between revisions

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==History==
==History==
History taking is one of the most important steps in diagnosing Glanzmann's thrombasthenia.
GT is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly  easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a sever hemorrhage after a surgery, such as circumcision. <ref name="pmid26185478">{{cite journal| author=Solh T, Botsford A, Solh M| title=Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. | journal=J Blood Med | year= 2015 | volume= 6 | issue=  | pages= 219-27 | pmid=26185478 | doi=10.2147/JBM.S71319 | pmc=4501245 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26185478  }}</ref> The severity of the presenting symptoms has no known relation to the affected gene.


==Symptoms==
==Symptoms==
Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage  
Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage  


It may include any of the following presentation:
It may include any of the following manifestation:


* Bruising easily
* Bruising easily (76.6%)
* Nosebleeds that do not stop easily
* Nosebleeds that do not stop easily (62.5%)
* Bleeding gums
* Bleeding gums (56.4%)
* Prolonged bleeding with minor injuries
* Prolonged bleeding with minor injuries (47.2%)
* Heavy menstrual bleeding
* Heavy menstrual bleeding
* postpartum bleeding
* postpartum bleeding
* gastrointestinal bleeding
* gastrointestinal bleeding
* Heavy bleeding during and after surgery
* Heavy bleeding during and after surgery
* bleeding into joints (rare)
* bleeding into joints (rare) <ref name="pmid27539755">{{cite journal| author=Iqbal I, Farhan S, Ahmed N| title=Glanzmann Thrombasthenia: A Clinicopathological Profile. | journal=J Coll Physicians Surg Pak | year= 2016 | volume= 26 | issue= 8 | pages= 647-50 | pmid=27539755 | doi=2396 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27539755  }}</ref>


==References==
==References==

Revision as of 09:48, 6 July 2018

Glanzmann's thrombasthenia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History

History taking is one of the most important steps in diagnosing Glanzmann's thrombasthenia.

GT is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a sever hemorrhage after a surgery, such as circumcision. [1] The severity of the presenting symptoms has no known relation to the affected gene.

Symptoms

Symptoms of Glanzmann's thrombasthenia varies from a minor bruise to a life-threatening hemorrhage

It may include any of the following manifestation:

  • Bruising easily (76.6%)
  • Nosebleeds that do not stop easily (62.5%)
  • Bleeding gums (56.4%)
  • Prolonged bleeding with minor injuries (47.2%)
  • Heavy menstrual bleeding
  • postpartum bleeding
  • gastrointestinal bleeding
  • Heavy bleeding during and after surgery
  • bleeding into joints (rare) [2]

References

  1. Solh T, Botsford A, Solh M (2015). "Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options". J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.
  2. Iqbal I, Farhan S, Ahmed N (2016). "Glanzmann Thrombasthenia: A Clinicopathological Profile". J Coll Physicians Surg Pak. 26 (8): 647–50. doi:2396 Check |doi= value (help). PMID 27539755.