Gestational trophoblastic neoplasia laboratory findings: Difference between revisions
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{{ | {{Gestational trophoblastic neoplasia}} | ||
{{CMG}}{{AE}}{{MD}} | |||
==Overview== | ==Overview== | ||
Elevated serum [[human chorionic gonadotropin]] is diagnostic of choriocarcinoma.<ref name=abc> Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015</ref><ref name= aaa> Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015</ref> | |||
==Laboratory Findings== | |||
===Quantitative serum HCG=== | |||
* [[Human chorionic gonadotropin]] (HCG or b-HCG) is the most common [[tumor]] marker test used to diagnose GTD<ref name=abc> Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015</ref> | |||
* HCG is markedly elevated (usu. >10,000 IU)<ref name= aaa> Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015</ref> | |||
* HCG is a very sensitive test for diagnosing most gestational trophoblastic tumors | |||
* HCG is usually measured in the blood, but it can also be measured in the [[urine]] | |||
* HCG levels are much higher in women with complete [[hydatidiform mole]]s and gestational choriocarcinoma compared to HCG levels in women with a normal [[pregnancy]] | |||
* With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD | |||
* With [[placental]] site tumors, the HCG level may be slightly higher than normal, but it is not considered a good marker for this type of tumor | |||
* An HCG test can help find GTD after pregnancy or [[miscarriage]] as this hormone should not be present in the blood or urine soon afterward | |||
===Human placental lactogen (hPL)=== | ===Human placental lactogen (hPL)=== | ||
* Human placental lactogen (hPL) is a | * Human placental lactogen (hPL) is a tumor marker that may be used to follow women with placental site [[trophoblastic]] tumors | ||
* Elevated hPL levels are found in women with some types of GTD | |||
===Complete blood count=== | |||
* [[Complete blood count]] can check for [[anemia ]] from long-term (chronic) [[vaginal bleeding]] | |||
=== | |||
===Kidney function tests=== | |||
=== | ===Liver function tests=== | ||
==References== | ==References== | ||
{{reflist| | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Gynecology]] | [[Category:Gynecology]] | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gynecology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 23:36, 26 November 2017
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Gestational trophoblastic neoplasia Microchapters |
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Differentiating Gestational trophoblastic neoplasia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Overview
Elevated serum human chorionic gonadotropin is diagnostic of choriocarcinoma.[1][2]
Laboratory Findings
Quantitative serum HCG
- Human chorionic gonadotropin (HCG or b-HCG) is the most common tumor marker test used to diagnose GTD[1]
- HCG is markedly elevated (usu. >10,000 IU)[2]
- HCG is a very sensitive test for diagnosing most gestational trophoblastic tumors
- HCG is usually measured in the blood, but it can also be measured in the urine
- HCG levels are much higher in women with complete hydatidiform moles and gestational choriocarcinoma compared to HCG levels in women with a normal pregnancy
- With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD
- With placental site tumors, the HCG level may be slightly higher than normal, but it is not considered a good marker for this type of tumor
- An HCG test can help find GTD after pregnancy or miscarriage as this hormone should not be present in the blood or urine soon afterward
Human placental lactogen (hPL)
- Human placental lactogen (hPL) is a tumor marker that may be used to follow women with placental site trophoblastic tumors
- Elevated hPL levels are found in women with some types of GTD
Complete blood count
- Complete blood count can check for anemia from long-term (chronic) vaginal bleeding
Kidney function tests
Liver function tests
References
- ↑ 1.0 1.1 Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015
- ↑ 2.0 2.1 Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015