Gastroparesis natural history, complications and prognosis: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 6: Line 6:


==Natural History==
==Natural History==
The natural history of gastroparesis is largely unknown. One study suggested that symptoms and gastric emptying in 20 patients with diabetes were generally stable over 12 years of follow-up. In another study of 86 diabetic patients who were followed for at least 9 years, delayed gastric emptying was not related with mortality after adjustment of comorbidities. However, other data from a tertiary setting over 6 years follow-up observed that 7% had died and 22% needed long-term parenteral or enteral feeding, suggesting gastroparesis is not a benign condition. Community studies of the outcome of gastroparesis are lacking, and studies conducted in tertiary referral centers may not reflect findings encountered in the general population.
In the Olmsted County epidemiology study, of all the incident cases of gastroparesis, one third patients died and another one third required medications, hospitalization or tube feeding related to gastroparesis.


Minimal data are available on the natural history of diabetic gastroparesis. From a group of 86 patients assessed at a tertiary referral center, 20 patients, of whom 16 had T1DM, were reevaluated 12 years later and only 13 patients (12 had T1DM) were reevaluated approximately 25 years after the first study.23,29 Although GE was not significantly different 25 years after the baseline assessment, correlation between initial and subsequent assessments was limited, as evidenced by a correlation coefficient of 0.56.23
There are limited data on long term natural history of gastroparesis.<ref name="pmid25667019">{{cite journal| author=Bharucha AE| title=Epidemiology and natural history of gastroparesis. | journal=Gastroenterol Clin North Am | year= 2015 | volume= 44 | issue= 1 | pages= 9-19 | pmid=25667019 | doi=10.1016/j.gtc.2014.11.002 | pmc=4323583 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25667019  }}</ref>
 
In the Olmsted County epidemiology study, of all the incident cases of gastroparesis, one third patients died and another one third required medications, hospitalization or tube feeding related to gastroparesis. There are limited data on long term natural history of gastroparesis.<ref name="pmid25667019">{{cite journal| author=Bharucha AE| title=Epidemiology and natural history of gastroparesis. | journal=Gastroenterol Clin North Am | year= 2015 | volume= 44 | issue= 1 | pages= 9-19 | pmid=25667019 | doi=10.1016/j.gtc.2014.11.002 | pmc=4323583 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25667019  }}</ref>


==Complications==
==Complications==

Revision as of 18:47, 7 February 2018

Gastroparesis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gastroparesis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Gastroparesis natural history, complications and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Gastroparesis natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Gastroparesis natural history, complications and prognosis

CDC on Gastroparesis natural history, complications and prognosis

Gastroparesis natural history, complications and prognosis in the news

Blogs on Gastroparesis natural history, complications and prognosis

Directions to Hospitals Treating Gastroparesis

Risk calculators and risk factors for Gastroparesis natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]

Overview

Natural History

In the Olmsted County epidemiology study, of all the incident cases of gastroparesis, one third patients died and another one third required medications, hospitalization or tube feeding related to gastroparesis.

There are limited data on long term natural history of gastroparesis.[1]

Complications

Primary complications of gastroparesis include:

Prognosis

Many treatments seem to provide only temporary benefit. The estimated 5-year survival for gastroparesis based on Gastroparesis study in Olmsted County, MN, as of January 1, 2007 was 67% with worse prognosis for diabetic gastroparesis.[2] Prognosis of diabetic gastroparesis mainly depends upon blood sugar level and duration of diabetes.

References

  1. Bharucha AE (2015). "Epidemiology and natural history of gastroparesis". Gastroenterol Clin North Am. 44 (1): 9–19. doi:10.1016/j.gtc.2014.11.002. PMC 4323583. PMID 25667019.
  2. Jung HK, Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Szarka LA; et al. (2009). "The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006". Gastroenterology. 136 (4): 1225–33. doi:10.1053/j.gastro.2008.12.047. PMC 2705939. PMID 19249393.

Template:WH Template:WS