Gastroparesis natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
In the Olmsted County epidemiology study, of all the incident cases of gastroparesis, one third patients died and another one third required medications hospitalization, or tube feeding related to gastroparesis. Overall survival of idiopathic gastroparesis was lower. There are limited data on long term natural history of gastroparesis.<ref name="pmid25667019">{{cite journal| author=Bharucha AE| title=Epidemiology and natural history of gastroparesis. | journal=Gastroenterol Clin North Am | year= 2015 | volume= 44 | issue= 1 | pages= 9-19 | pmid=25667019 | doi=10.1016/j.gtc.2014.11.002 | pmc=4323583 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25667019 }}</ref> | In the Olmsted County epidemiology study, of all the incident cases of gastroparesis, one third patients died and another one third required medications, hospitalization, or tube feeding related to gastroparesis. Overall survival of idiopathic gastroparesis was lower. There are limited data on long term natural history of gastroparesis.<ref name="pmid25667019">{{cite journal| author=Bharucha AE| title=Epidemiology and natural history of gastroparesis. | journal=Gastroenterol Clin North Am | year= 2015 | volume= 44 | issue= 1 | pages= 9-19 | pmid=25667019 | doi=10.1016/j.gtc.2014.11.002 | pmc=4323583 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25667019 }}</ref> | ||
==Complications== | ==Complications== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]
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Overview
Natural History
In the Olmsted County epidemiology study, of all the incident cases of gastroparesis, one third patients died and another one third required medications, hospitalization, or tube feeding related to gastroparesis. Overall survival of idiopathic gastroparesis was lower. There are limited data on long term natural history of gastroparesis.[1]
Complications
Primary complications of gastroparesis include:
- Fluctuations in blood glucose due to unpredictable digestion times (in diabetic patients)
- General malnutrition due to the symptoms of the disease (which frequently include vomiting and reduced appetite) as well as the dietary changes necessary to manage it
- Severe fatigue and weight loss due to calorie deficit
- Intestinal obstruction due to the formation of bezoars (solid masses of undigested food)
- Bacterial infection due to overgrowth in undigested food
- Dehydration
- Electrolyte imbalances
Prognosis
Many treatments seem to provide only temporary benefit. The estimated 5-year survival for gastroparesis based on Gastroparesis study in Olmsted County, MN, as of January 1, 2007 was 67% with worse prognosis for diabetic gastroparesis.[2]
References
- ↑ Bharucha AE (2015). "Epidemiology and natural history of gastroparesis". Gastroenterol Clin North Am. 44 (1): 9–19. doi:10.1016/j.gtc.2014.11.002. PMC 4323583. PMID 25667019.
- ↑ Jung HK, Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Szarka LA; et al. (2009). "The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006". Gastroenterology. 136 (4): 1225–33. doi:10.1053/j.gastro.2008.12.047. PMC 2705939. PMID 19249393.