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{{Infobox_gene}}
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'''G protein-coupled receptor kinase 6''' is an [[enzyme]] that in humans is encoded by the ''GRK6'' [[gene]].<ref name="pmid8415712">{{cite journal |vauthors=Haribabu B, Snyderman R | title = Identification of additional members of human G-protein-coupled receptor kinase multigene family | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 20 | pages = 9398–402 |date=Nov 1993 | pmid = 8415712 | pmc = 47575 | doi =10.1073/pnas.90.20.9398 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GRK6 G protein-coupled receptor kinase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2870| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_GRK6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2acx.
| PDB = {{PDB2|2acx}}
| Name = G protein-coupled receptor kinase 6
| HGNCid = 4545
| Symbol = GRK6
| AltSymbols =; FLJ32135; GPRK6
| OMIM = 600869
| ECnumber =
| Homologene = 37570
| MGIid = 1347078
| GeneAtlas_image1 = PBB_GE_GRK6_210981_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GRK6_202848_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GRK6_202849_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004703 |text = G-protein coupled receptor kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008277 |text = regulation of G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2870
    | Hs_Ensembl = ENSG00000198055
    | Hs_RefseqProtein = NP_001004105
    | Hs_RefseqmRNA = NM_001004105
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 176786294
    | Hs_GenLoc_end = 176801434
    | Hs_Uniprot = P43250
    | Mm_EntrezGene = 26385
    | Mm_Ensembl = ENSMUSG00000074886
    | Mm_RefseqmRNA = NM_001038018
    | Mm_RefseqProtein = NP_001033107
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 55455086
    | Mm_GenLoc_end = 55469496
    | Mm_Uniprot = Q9EPB9
  }}
}}
'''G protein-coupled receptor kinase 6''', also known as '''GRK6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRK6 G protein-coupled receptor kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2870| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GRK6 G protein-coupled receptor kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2870| accessdate = }}</ref>
| summary_text = This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.<ref name="entrez" /> GRK6 appears to be involved in responses to [[morphine]].<ref name="pmid19497686">{{cite journal |vauthors=Raehal KM, Schmid CL, Medvedev IO, Gainetdinov RR, Premont RT, Bohn LM |title=Morphine-Induced Physiological and Behavioral Responses in Mice Lacking G Protein-Coupled Receptor Kinase 6 |journal=Drug and Alcohol Dependence |volume= 104|issue= 3|pages= 187–96|date=June 2009 |pmid=19497686 |doi=10.1016/j.drugalcdep.2009.04.011 |url= |pmc=2771341}}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bullrich F, Druck T, Kunapuli P, ''et al.'' |title=Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 250-4 |year= 1995 |pmid= 7789183 |doi= }}
*{{cite journal  | author=Bullrich F |title=Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6 |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3–4 |pages= 250–4 |year= 1995 |pmid= 7789183 |doi=10.1159/000134045 |name-list-format=vanc| author2=Druck T  | author3=Kunapuli P  | display-authors=3  | last4=Gomez  | first4=J. | last5=Gripp  | first5=K.W.  | last6=Schlegelberger  | first6=B.  | last7=Lasota  | first7=J. | last8=Aronson | first8=M.  | last9=Cannizzaro  | first9=L.A.  }}
*{{cite journal | author=Stoffel RH, Randall RR, Premont RT, ''et al.'' |title=Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 27791-4 |year= 1994 |pmid= 7961702 |doi=  }}
*{{cite journal  | author=Stoffel RH |title=Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 27791–4 |year= 1994 |pmid= 7961702 |doi=  |name-list-format=vanc| author2=Randall RR  | author3=Premont RT  | display-authors=3  | last4=Lefkowitz  | first4=RJ  | last5=Inglese  | first5=J }}
*{{cite journal | author=Loudon RP, Benovic JL |title=Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. |journal=J. Biol. Chem. |volume=269 |issue= 36 |pages= 22691-7 |year= 1994 |pmid= 8077221 |doi= }}
*{{cite journal  |vauthors=Loudon RP, Benovic JL |title=Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6 |journal=J. Biol. Chem. |volume=269 |issue= 36 |pages= 22691–7 |year= 1994 |pmid= 8077221 |doi=  }}
*{{cite journal  | author=Benovic JL, Gomez J |title=Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. |journal=J. Biol. Chem. |volume=268 |issue= 26 |pages= 19521-7 |year= 1993 |pmid= 8366096 |doi= }}
*{{cite journal  |vauthors=Benovic JL, Gomez J |title=Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family |journal=J. Biol. Chem. |volume=268 |issue= 26 |pages= 19521–7 |year= 1993 |pmid= 8366096 |doi=  }}
*{{cite journal | author=Haribabu B, Snyderman R |title=Identification of additional members of human G-protein-coupled receptor kinase multigene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 20 |pages= 9398-402 |year= 1993 |pmid= 8415712 |doi=  }}
*{{cite journal  | author=Freedman NJ |title=Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17734–43 |year= 1997 |pmid= 9211925 |doi=10.1074/jbc.272.28.17734 |name-list-format=vanc| author2=Ament AS  | author3=Oppermann M  | display-authors=3  | last4=Stoffel  | first4=RH  | last5=Exum  | first5=ST  | last6=Lefkowitz  | first6=RJ }}
*{{cite journal  | author=Freedman NJ, Ament AS, Oppermann M, ''et al.'' |title=Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17734-43 |year= 1997 |pmid= 9211925 |doi=  }}
*{{cite journal  |vauthors=Loudon RP, Benovic JL |title=Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6 |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27422–7 |year= 1997 |pmid= 9341194 |doi=10.1074/jbc.272.43.27422  }}
*{{cite journal  | author=Loudon RP, Benovic JL |title=Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27422-7 |year= 1997 |pmid= 9341194 |doi=  }}
*{{cite journal  | author=Stoffel RH |title=Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6 |journal=Biochemistry |volume=37 |issue= 46 |pages= 16053–9 |year= 1998 |pmid= 9819198 |doi= 10.1021/bi981432d |name-list-format=vanc| author2=Inglese J  | author3=Macrae AD  | display-authors=3  | last4=Lefkowitz  | first4=Robert J. | last5=Premont  | first5=Richard T. }}
*{{cite journal  | author=Stoffel RH, Inglese J, Macrae AD, ''et al.'' |title=Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. |journal=Biochemistry |volume=37 |issue= 46 |pages= 16053-9 |year= 1998 |pmid= 9819198 |doi= 10.1021/bi981432d }}
*{{cite journal  | author=Premont RT |title=β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 24 |pages= 14082–7 |year= 1998 |pmid= 9826657 |doi=10.1073/pnas.95.24.14082 | pmc=24330 |name-list-format=vanc| author2=Claing A  | author3=Vitale N  | display-authors=3  | last4=Freeman  | first4=JL  | last5=Pitcher  | first5=JA  | last6=Patton  | first6=WA  | last7=Moss  | first7=J  | last8=Vaughan  | first8=M  | last9=Lefkowitz  | first9=RJ }}
*{{cite journal | author=Premont RT, Claing A, Vitale N, ''et al.'' |title=beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 24 |pages= 14082-7 |year= 1998 |pmid= 9826657 |doi=  }}
*{{cite journal  | author=Milcent MD |title=Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 1 |pages= 224–9 |year= 1999 |pmid= 10334944 |doi= 10.1006/bbrc.1999.0758 |name-list-format=vanc| author2=Christophe T  | author3=Rabiet MJ  | display-authors=3  | last4=Tardif  | first4=Marianne  | last5=Boulay  | first5=François }}
*{{cite journal  | author=Milcent MD, Christophe T, Rabiet MJ, ''et al.'' |title=Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 1 |pages= 224-9 |year= 1999 |pmid= 10334944 |doi= 10.1006/bbrc.1999.0758 }}
*{{cite journal  | author=Lazari MF |title=Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor |journal=Mol. Endocrinol. |volume=13 |issue= 6 |pages= 866–78 |year= 1999 |pmid= 10379886 |doi=10.1210/me.13.6.866 |name-list-format=vanc| author2=Liu X  | author3=Nakamura K  | display-authors=3  | last4=Benovic  | first4=JL  | last5=Ascoli  | first5=M  }}
*{{cite journal  | author=Lazari MF, Liu X, Nakamura K, ''et al.'' |title=Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor. |journal=Mol. Endocrinol. |volume=13 |issue= 6 |pages= 866-78 |year= 1999 |pmid= 10379886 |doi= }}
*{{cite journal  | author=Hall RA |title=G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24328–34 |year= 1999 |pmid= 10446210 |doi=10.1074/jbc.274.34.24328 |name-list-format=vanc| author2=Spurney RF  | author3=Premont RT  | display-authors=3  | last4=Rahman  | first4=N  | last5=Blitzer  | first5=JT  | last6=Pitcher  | first6=JA  | last7=Lefkowitz  | first7=RJ  }}
*{{cite journal | author=Hall RA, Spurney RF, Premont RT, ''et al.'' |title=G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24328-34 |year= 1999 |pmid= 10446210 |doi=  }}
*{{cite journal  |vauthors=Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S |title=Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium |journal=J. Endocrinol. |volume=162 |issue= 3 |pages= 401–8 |year= 1999 |pmid= 10467231 |doi=10.1677/joe.0.1620401  }}
*{{cite journal  | author=Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S |title=Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium. |journal=J. Endocrinol. |volume=162 |issue= 3 |pages= 401-8 |year= 1999 |pmid= 10467231 |doi=  }}
*{{cite journal  | author=Premont RT |title=The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29381–9 |year= 1999 |pmid= 10506199 |doi=10.1074/jbc.274.41.29381  |name-list-format=vanc| author2=Macrae AD  | author3=Aparicio SA  | display-authors=3  | last4=Kendall  | first4=HE  | last5=Welch  | first5=JE  | last6=Lefkowitz  | first6=RJ  }}
*{{cite journal | author=Premont RT, Macrae AD, Aparicio SA, ''et al.'' |title=The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29381-9 |year= 1999 |pmid= 10506199 |doi=  }}
*{{cite journal  |vauthors=Pronin AN, Morris AJ, Surguchov A, Benovic JL |title=Synucleins are a novel class of substrates for G protein-coupled receptor kinases |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26515–22 |year= 2000 |pmid= 10852916 |doi= 10.1074/jbc.M003542200 }}
*{{cite journal  | author=Pronin AN, Morris AJ, Surguchov A, Benovic JL |title=Synucleins are a novel class of substrates for G protein-coupled receptor kinases. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26515-22 |year= 2000 |pmid= 10852916 |doi= 10.1074/jbc.M003542200 }}
*{{cite journal  | author=Tiruppathi C |title=G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7440–5 |year= 2000 |pmid= 10861009 |doi=10.1073/pnas.97.13.7440  | pmc=16564  |name-list-format=vanc| author2=Yan W  | author3=Sandoval R  | display-authors=3  | last4=Naqvi  | first4=T  | last5=Pronin  | first5=AN  | last6=Benovic  | first6=JL  | last7=Malik  | first7=AB  }}
*{{cite journal | author=Tiruppathi C, Yan W, Sandoval R, ''et al.'' |title=G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7440-5 |year= 2000 |pmid= 10861009 |doi=  }}
*{{cite journal  |vauthors=Zhou H, Yan F, Tai HH |title=Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases |journal=J. Pharmacol. Exp. Ther. |volume=298 |issue= 3 |pages= 1243–51 |year= 2001 |pmid= 11504827 |doi=  }}
*{{cite journal  | author=Zhou H, Yan F, Tai HH |title=Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. |journal=J. Pharmacol. Exp. Ther. |volume=298 |issue= 3 |pages= 1243-51 |year= 2001 |pmid= 11504827 |doi= }}
*{{cite journal  | author=Blaukat A |title=Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40431–40 |year= 2001 |pmid= 11517230 |doi= 10.1074/jbc.M107024200  |name-list-format=vanc| author2=Pizard A  | author3=Breit A  | display-authors=3  | last4=Wernstedt  | first4=C  | last5=Alhenc-Gelas  | first5=F  | last6=Muller-Esterl  | first6=W  | last7=Dikic  | first7=I }}
*{{cite journal | author=Blaukat A, Pizard A, Breit A, ''et al.'' |title=Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40431-40 |year= 2001 |pmid= 11517230 |doi= 10.1074/jbc.M107024200 }}
*{{cite journal  |vauthors=Willets JM, Challiss RA, Nahorski SR |title=Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15523–9 |year= 2002 |pmid= 11856737 |doi= 10.1074/jbc.M111217200 }}
*{{cite journal  | author=Willets JM, Challiss RA, Nahorski SR |title=Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15523-9 |year= 2002 |pmid= 11856737 |doi= 10.1074/jbc.M111217200 }}
*{{cite journal  | author=Grange-Midroit M |title=G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution |journal=Brain Res. Mol. Brain Res. |volume=101 |issue= 1–2 |pages= 39–51 |year= 2002 |pmid= 12007830 |doi=10.1016/S0169-328X(02)00144-4  |name-list-format=vanc| author2=García-Sevilla JA  | author3=Ferrer-Alcón M  | display-authors=3  | last4=La Harpe  | first4=R  | last5=Walzer  | first5=C  | last6=Guimón  | first6=J }}
*{{cite journal | author=Grange-Midroit M, García-Sevilla JA, Ferrer-Alcón M, ''et al.'' |title=G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution. |journal=Brain Res. Mol. Brain Res. |volume=101 |issue= 1-2 |pages= 39-51 |year= 2002 |pmid= 12007830 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 01:52, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

G protein-coupled receptor kinase 6 is an enzyme that in humans is encoded by the GRK6 gene.[1][2]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.[2] GRK6 appears to be involved in responses to morphine.[3]

References

  1. ↑ Haribabu B, Snyderman R (Nov 1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family". Proc Natl Acad Sci U S A. 90 (20): 9398–402. doi:10.1073/pnas.90.20.9398. PMC 47575. PMID 8415712.
  2. ↑ 2.0 2.1 "Entrez Gene: GRK6 G protein-coupled receptor kinase 6".
  3. ↑ Raehal KM, Schmid CL, Medvedev IO, Gainetdinov RR, Premont RT, Bohn LM (June 2009). "Morphine-Induced Physiological and Behavioral Responses in Mice Lacking G Protein-Coupled Receptor Kinase 6". Drug and Alcohol Dependence. 104 (3): 187–96. doi:10.1016/j.drugalcdep.2009.04.011. PMC 2771341. PMID 19497686.

Further reading

  • Bullrich F, Druck T, Kunapuli P, et al. (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6". Cytogenet. Cell Genet. 70 (3–4): 250–4. doi:10.1159/000134045. PMID 7789183.
  • Stoffel RH, Randall RR, Premont RT, et al. (1994). "Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family". J. Biol. Chem. 269 (45): 27791–4. PMID 7961702.
  • Loudon RP, Benovic JL (1994). "Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6". J. Biol. Chem. 269 (36): 22691–7. PMID 8077221.
  • Benovic JL, Gomez J (1993). "Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family". J. Biol. Chem. 268 (26): 19521–7. PMID 8366096.
  • Freedman NJ, Ament AS, Oppermann M, et al. (1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity". J. Biol. Chem. 272 (28): 17734–43. doi:10.1074/jbc.272.28.17734. PMID 9211925.
  • Loudon RP, Benovic JL (1997). "Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6". J. Biol. Chem. 272 (43): 27422–7. doi:10.1074/jbc.272.43.27422. PMID 9341194.
  • Stoffel RH, Inglese J, Macrae AD, et al. (1998). "Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6". Biochemistry. 37 (46): 16053–9. doi:10.1021/bi981432d. PMID 9819198.
  • Premont RT, Claing A, Vitale N, et al. (1998). "β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14082–7. doi:10.1073/pnas.95.24.14082. PMC 24330. PMID 9826657.
  • Milcent MD, Christophe T, Rabiet MJ, et al. (1999). "Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells". Biochem. Biophys. Res. Commun. 259 (1): 224–9. doi:10.1006/bbrc.1999.0758. PMID 10334944.
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