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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Glutamate [NMDA] receptor subunit 3A''' is a [[protein]] that in humans is encoded by the ''GRIN3A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116443| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
| HGNCid = 16767
| Symbol = GRIN3A
| AltSymbols =; FLJ45414; NMDAR-L; NR3A
| OMIM = 606650
| ECnumber = 
| Homologene = 15851
| MGIid = 
| GeneAtlas_image1 = PBB_GE_GRIN3A_gnf1h05166_at_tn.png
| GeneAtlas_image2 = PBB_GE_GRIN3A_gnf1h08344_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004970 |text = ionotropic glutamate receptor activity}} {{GNF_GO|id=GO:0004972 |text = N-methyl-D-aspartate selective glutamate receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005234 |text = extracellular-glutamate-gated ion channel activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0016358 |text = dendrite development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 116443
    | Hs_Ensembl = ENSG00000198785
    | Hs_RefseqProtein = NP_597702
    | Hs_RefseqmRNA = NM_133445
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 103371456
    | Hs_GenLoc_end = 103540683
    | Hs_Uniprot = Q8TCU5
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A''', also known as '''GRIN3A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116443| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a subunit of the N-methyl-D-aspartate ([[NMDAR]]) receptors, which belong to the superfamily of [[glutamate receptor|glutamate-regulated ion channels]], and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the [[knockout mouse]] deficient in this subunit suggest that this gene may be involved in the development of [[synapse|synaptic]] elements by modulating NMDA receptor activity.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
==See also==
| summary_text = This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.<ref name="entrez">{{cite web | title = Entrez Gene: GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116443| accessdate = }}</ref>
* [[NMDA receptor]]
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE | title = Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. | journal = Neurotoxicology | volume = 19 | issue = 4-5 | pages = 683–8 | year = 1998 | pmid = 9745929 | doi =  }}
| citations =
*{{cite journal |vauthors=Eriksson M, Nilsson A, Samuelsson H, Samuelsson EB, Mo L, Akesson E, Benedikz E, Sundström E | title = On the role of NR3A in human NMDA receptors. | journal = Physiol. Behav. | volume = 92 | issue = 1-2 | pages = 54–9 | year = 2007 | pmid = 17617428 | doi = 10.1016/j.physbeh.2007.05.026 }}
*{{cite journal | author=Schröder HC, Perovic S, Kavsan V, ''et al.'' |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683-8 |year= 1998 |pmid= 9745929 |doi=  }}
*{{cite journal |vauthors=Kornau HC, Schenker LT, Kennedy MB, Seeburg PH | title = Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. | journal = Science | volume = 269 | issue = 5231 | pages = 1737–40 | year = 1995 | pmid = 7569905 | doi = 10.1126/science.7569905 }}
*{{cite journal | author=Eriksson M, Nilsson A, Samuelsson H, ''et al.'' |title=On the role of NR3A in human NMDA receptors. |journal=Physiol. Behav. |volume=92 |issue= 1-2 |pages= 54-9 |year= 2007 |pmid= 17617428 |doi= 10.1016/j.physbeh.2007.05.026 }}
*{{cite journal |vauthors=Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A | title = Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. | journal = Ann. Neurol. | volume = 37 | issue = 3 | pages = 373–80 | year = 1995 | pmid = 7695237 | doi = 10.1002/ana.410370314 }}
*{{cite journal | author=Kornau HC, Schenker LT, Kennedy MB, Seeburg PH |title=Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. |journal=Science |volume=269 |issue= 5231 |pages= 1737-40 |year= 1995 |pmid= 7569905 |doi= }}
*{{cite journal |vauthors=Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M | title = HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons. | journal = Eur. J. Neurosci. | volume = 7 | issue = 11 | pages = 2285–93 | year = 1996 | pmid = 8563977 | doi = 10.1111/j.1460-9568.1995.tb00649.x }}
*{{cite journal | author=Magnuson DS, Knudsen BE, Geiger JD, ''et al.'' |title=Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. |journal=Ann. Neurol. |volume=37 |issue= 3 |pages= 373-80 |year= 1995 |pmid= 7695237 |doi= 10.1002/ana.410370314 }}
*{{cite journal |vauthors=Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G | title = Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. | journal = Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration | volume = 4 | issue = 3 | pages = 315–21 | year = 1996 | pmid = 8581564 | doi = 10.1016/1055-8330(95)90021-7 }}
*{{cite journal | author=Lannuzel A, Lledo PM, Lamghitnia HO, ''et al.'' |title=HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons. |journal=Eur. J. Neurosci. |volume=7 |issue= 11 |pages= 2285-93 |year= 1996 |pmid= 8563977 |doi= }}
*{{cite journal |vauthors=Pittaluga A, Pattarini R, Severi P, Raiteri M | title = Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120. | journal = AIDS | volume = 10 | issue = 5 | pages = 463–8 | year = 1996 | pmid = 8724036 | doi = 10.1097/00002030-199605000-00003 }}
*{{cite journal | author=Corasaniti MT, Melino G, Navarra M, ''et al.'' |title=Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. |journal=Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration |volume=4 |issue= 3 |pages= 315-21 |year= 1996 |pmid= 8581564 |doi= }}
*{{cite journal |vauthors=Wu P, Price P, Du B, Hatch WC, Terwilliger EF | title = Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. | journal = NeuroReport | volume = 7 | issue = 5 | pages = 1045–9 | year = 1996 | pmid = 8804048 | doi = 10.1097/00001756-199604100-00018 }}
*{{cite journal | author=Pittaluga A, Pattarini R, Severi P, Raiteri M |title=Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120. |journal=AIDS |volume=10 |issue= 5 |pages= 463-8 |year= 1996 |pmid= 8724036 |doi= }}
*{{cite journal |vauthors=Bennett BA, Rusyniak DE, Hollingsworth CK | title = HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures. | journal = Brain Res. | volume = 705 | issue = 1-2 | pages = 168–76 | year = 1996 | pmid = 8821747 | doi = 10.1016/0006-8993(95)01166-8 }}
*{{cite journal | author=Wu P, Price P, Du B, ''et al.'' |title=Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. |journal=Neuroreport |volume=7 |issue= 5 |pages= 1045-9 |year= 1996 |pmid= 8804048 |doi= }}
*{{cite journal |vauthors=Toggas SM, Masliah E, Mucke L | title = Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. | journal = Brain Res. | volume = 706 | issue = 2 | pages = 303–7 | year = 1996 | pmid = 8822372 | doi = 10.1016/0006-8993(95)01197-8 }}
*{{cite journal | author=Bennett BA, Rusyniak DE, Hollingsworth CK |title=HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures. |journal=Brain Res. |volume=705 |issue= 1-2 |pages= 168-76 |year= 1996 |pmid= 8821747 |doi= }}
*{{cite journal |vauthors=Dreyer EB, Lipton SA | title = The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. | journal = Eur. J. Neurosci. | volume = 7 | issue = 12 | pages = 2502–7 | year = 1996 | pmid = 8845955 | doi = 10.1111/j.1460-9568.1995.tb01048.x }}
*{{cite journal | author=Toggas SM, Masliah E, Mucke L |title=Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. |journal=Brain Res. |volume=706 |issue= 2 |pages= 303-7 |year= 1996 |pmid= 8822372 |doi= }}
*{{cite journal |vauthors=Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L | title = Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase. | journal = Virology | volume = 226 | issue = 2 | pages = 362–73 | year = 1997 | pmid = 8955056 | doi = 10.1006/viro.1996.0664 }}
*{{cite journal | author=Dreyer EB, Lipton SA |title=The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. |journal=Eur. J. Neurosci. |volume=7 |issue= 12 |pages= 2502-7 |year= 1996 |pmid= 8845955 |doi= }}
*{{cite journal |vauthors=Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N | title = Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. | journal = Nature | volume = 393 | issue = 6683 | pages = 377–81 | year = 1998 | pmid = 9620802 | doi = 10.1038/30748 }}
*{{cite journal | author=Raber J, Toggas SM, Lee S, ''et al.'' |title=Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase. |journal=Virology |volume=226 |issue= 2 |pages= 362-73 |year= 1997 |pmid= 8955056 |doi= 10.1006/viro.1996.0664 }}
*{{cite journal |vauthors=New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA | title = HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. | journal = J. Biol. Chem. | volume = 273 | issue = 28 | pages = 17852–8 | year = 1998 | pmid = 9651389 | doi = 10.1074/jbc.273.28.17852 }}
*{{cite journal | author=Das S, Sasaki YF, Rothe T, ''et al.'' |title=Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. |journal=Nature |volume=393 |issue= 6683 |pages= 377-81 |year= 1998 |pmid= 9620802 |doi= 10.1038/30748 }}
*{{cite journal |vauthors=Wang P, Barks JD, Silverstein FS | title = Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats. | journal = Neuroscience | volume = 88 | issue = 2 | pages = 585–97 | year = 1999 | pmid = 10197777 | doi = 10.1016/S0306-4522(98)00242-5 }}
*{{cite journal | author=New DR, Maggirwar SB, Epstein LG, ''et al.'' |title=HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17852-8 |year= 1998 |pmid= 9651389 |doi= }}
*{{cite journal |vauthors=Howard SA, Nakayama AY, Brooke SM, Sapolsky RM | title = Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures. | journal = Exp. Neurol. | volume = 158 | issue = 1 | pages = 164–70 | year = 1999 | pmid = 10448428 | doi = 10.1006/exnr.1999.7080 }}
*{{cite journal | author=Wang P, Barks JD, Silverstein FS |title=Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats. |journal=Neuroscience |volume=88 |issue= 2 |pages= 585-97 |year= 1999 |pmid= 10197777 |doi= }}
*{{cite journal |vauthors=Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K | title = Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system. | journal = AIDS Res. Hum. Retroviruses | volume = 15 | issue = 16 | pages = 1461–7 | year = 1999 | pmid = 10555109 | doi = 10.1089/088922299309973 }}
*{{cite journal | author=Howard SA, Nakayama AY, Brooke SM, Sapolsky RM |title=Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures. |journal=Exp. Neurol. |volume=158 |issue= 1 |pages= 164-70 |year= 1999 |pmid= 10448428 |doi= 10.1006/exnr.1999.7080 }}
*{{cite journal |vauthors=Perez-Otano I, Schulteis CT, Contractor A, Lipton SA, Trimmer JS, Sucher NJ, Heinemann SF | title = Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. | journal = J. Neurosci. | volume = 21 | issue = 4 | pages = 1228–37 | year = 2001 | pmid = 11160393 | doi =  }}
*{{cite journal | author=Xin KQ, Hamajima K, Hattori S, ''et al.'' |title=Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system. |journal=AIDS Res. Hum. Retroviruses |volume=15 |issue= 16 |pages= 1461-7 |year= 1999 |pmid= 10555109 |doi= 10.1089/088922299309973 }}
*{{cite journal |vauthors=Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD | title = HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. | journal = J. Neurochem. | volume = 78 | issue = 3 | pages = 457–67 | year = 2001 | pmid = 11483648 | doi = 10.1046/j.1471-4159.2001.00396.x }}
*{{cite journal | author=Perez-Otano I, Schulteis CT, Contractor A, ''et al.'' |title=Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. |journal=J. Neurosci. |volume=21 |issue= 4 |pages= 1228-37 |year= 2001 |pmid= 11160393 |doi=  }}
*{{cite journal | author=Haughey NJ, Nath A, Mattson MP, ''et al.'' |title=HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. |journal=J. Neurochem. |volume=78 |issue= 3 |pages= 457-67 |year= 2001 |pmid= 11483648 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{MeshName|GRIN3A+protein,+human}}
 
{{Ligand-gated ion channels}}
 
 
 
{{gene-9-stub}}
 
[[Category:Ionotropic glutamate receptors]]

Latest revision as of 02:03, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glutamate [NMDA] receptor subunit 3A is a protein that in humans is encoded by the GRIN3A gene.[1]

Function

This gene encodes a subunit of the N-methyl-D-aspartate (NMDAR) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A".

Further reading

  • Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
  • Eriksson M, Nilsson A, Samuelsson H, Samuelsson EB, Mo L, Akesson E, Benedikz E, Sundström E (2007). "On the role of NR3A in human NMDA receptors". Physiol. Behav. 92 (1–2): 54–9. doi:10.1016/j.physbeh.2007.05.026. PMID 17617428.
  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. doi:10.1126/science.7569905. PMID 7569905.
  • Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.
  • Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977.
  • Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564.
  • Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036.
  • Wu P, Price P, Du B, Hatch WC, Terwilliger EF (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons". NeuroReport. 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID 8804048.
  • Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures". Brain Res. 705 (1–2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID 8821747.
  • Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372.
  • Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID 8845955.
  • Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase". Virology. 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056.
  • Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N (1998). "Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A". Nature. 393 (6683): 377–81. doi:10.1038/30748. PMID 9620802.
  • New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism". J. Biol. Chem. 273 (28): 17852–8. doi:10.1074/jbc.273.28.17852. PMID 9651389.
  • Wang P, Barks JD, Silverstein FS (1999). "Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats". Neuroscience. 88 (2): 585–97. doi:10.1016/S0306-4522(98)00242-5. PMID 10197777.
  • Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999). "Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures". Exp. Neurol. 158 (1): 164–70. doi:10.1006/exnr.1999.7080. PMID 10448428.
  • Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system". AIDS Res. Hum. Retroviruses. 15 (16): 1461–7. doi:10.1089/088922299309973. PMID 10555109.
  • Perez-Otano I, Schulteis CT, Contractor A, Lipton SA, Trimmer JS, Sucher NJ, Heinemann SF (2001). "Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors". J. Neurosci. 21 (4): 1228–37. PMID 11160393.
  • Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD (2001). "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity". J. Neurochem. 78 (3): 457–67. doi:10.1046/j.1471-4159.2001.00396.x. PMID 11483648.

External links


Retrieved from "https://www.wikidoc.org/index.php?title=GRIN3A&oldid=1422548"