Glycine receptor subunit beta is a protein that in humans is encoded by the GLRBgene.[1][2][3]
The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][3]
↑Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics. 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID9676428.
↑Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res. 35 (1–2): 211–9. doi:10.1016/0169-328x(95)00218-h. PMID8717357.
Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron. 15 (3): 563–72. doi:10.1016/0896-6273(95)90145-0. PMID7546736.
Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron. 82 (3): 254–60. doi:10.1159/000045410. PMID10395998.
Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. doi:10.1093/hmg/11.7.853. PMID11929858.
Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID14563849.
Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels. 9 (6): 353–61. PMID14698963.
Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering". J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMID15215304.
Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron. 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID15748848.
