GLYCAM1: Difference between revisions

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'''Glycosylation-dependent [[cell adhesion molecule]]-1''' ('''GLYCAM1''') is a [[proteoglycan]] [[ligand]] expressed on cells of the [[high endothelial venule]]s in lymph nodes. It is able to bind to the receptor [[L-selectin]] during inflammation, acting as a homing beacon for [[leukocyte]]s expressing the receptor to enter the site of inflammation.<ref name="robspath">{{cite book |title=Robbins Pathologic Basis of Disease |last1=Cotran |first1=Ramzi S. |last2=Kumar |first2=Vinay |last3=Collins |first3=Tucker |publisher=W.B Saunders Company |location=Philadelphia |isbn=0-7216-7335-X}}{{pn|date=May 2016}}</ref>
'''Glycosylation-dependent [[cell adhesion molecule]]-1''' ('''GLYCAM1''') is a [[proteoglycan]] [[ligand]] expressed on cells of the [[high endothelial venule]]s in lymphoid tissues. It is the ligand for the receptor [[L-selectin]] allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.<ref name=":0">{{Cite book|url=http://linkinghub.elsevier.com/retrieve/pii/S0065277608606239|title=Leukocyte Migration and Adhesion|last=Imhof|first=Beat A.|last2=Dunon|first2=Dominique|pages=345–416|doi=10.1016/s0065-2776(08)60623-9}}</ref><ref>{{Cite journal|last=|first=|last2=|date=1 November 1992|title=Identification of a soluble form of a ligand for the lymphocyte homing receptor|pmc=2119429|journal=The Journal of Experimental Medicine|volume=176|issue=5|pages=1415–1419|pmid=1383387|via=}}</ref>
GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.{{fact|date=May 2016}}
GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.{{citation needed|date=May 2016}}
Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.<ref>{{cite journal |last1=Dowbenko |first1=D |last2=Kikuta |first2=A |last3=Fennie |first3=C |last4=Gillett |first4=N |last5=Lasky |first5=L A |title=Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk. |journal=Journal of Clinical Investigation |volume=92 |issue=2 |pages=952–60 |year=1993 |pmid=8349827 |pmc=294935 |doi=10.1172/JCI116671 }}</ref>
Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.<ref>{{cite journal | vauthors = Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA | title = Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk | journal = The Journal of Clinical Investigation | volume = 92 | issue = 2 | pages = 952–60 | date = August 1993 | pmid = 8349827 | pmc = 294935 | doi = 10.1172/JCI116671 }}</ref>


==External links==
GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.<ref name=":0" />
 
== External links ==
* {{MeshName|GlyCAM-1}}
* {{MeshName|GlyCAM-1}}


Latest revision as of 23:19, 29 November 2018

glycosylation dependent cell adhesion molecule-1
Identifiers
SymbolGLYCAM1
Entrez644076
HUGO18023
RefSeqXM_927461
UniProtQ8IVK1
Other data
LocusChr. 12 q13.2

Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.[1][2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[citation needed] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[3]

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.[1]

External links

References

  1. ↑ 1.0 1.1 Imhof, Beat A.; Dunon, Dominique. Leukocyte Migration and Adhesion. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9.
  2. ↑ "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. 1 November 1992. PMC 2119429. PMID 1383387.
  3. ↑ Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". The Journal of Clinical Investigation. 92 (2): 952–60. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.


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