GLYCAM1: Difference between revisions
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'''Glycosylation-dependent [[cell adhesion molecule]]-1''' ('''GLYCAM1''') is a [[proteoglycan]] [[ligand]] expressed on cells of the [[high endothelial venule]]s in lymph nodes. It is able to bind to the receptor [[L-selectin]] during inflammation, acting as a homing beacon for [[leukocyte]]s expressing the receptor to enter the site of inflammation.<ref name="robspath">{{cite book |title=Robbins Pathologic Basis of Disease |last1=Cotran |first1=Ramzi S. |last2=Kumar |first2=Vinay |last3=Collins |first3=Tucker |publisher=W.B Saunders Company |location=Philadelphia |isbn=0-7216-7335-X}}{{pn|date=May 2016}}</ref> | |||
GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.{{fact|date=May 2016}} | |||
Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.<ref>{{cite journal |last1=Dowbenko |first1=D |last2=Kikuta |first2=A |last3=Fennie |first3=C |last4=Gillett |first4=N |last5=Lasky |first5=L A |title=Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk. |journal=Journal of Clinical Investigation |volume=92 |issue=2 |pages=952–60 |year=1993 |pmid=8349827 |pmc=294935 |doi=10.1172/JCI116671 }}</ref> | |||
'''Glycosylation-dependent [[cell adhesion molecule]]-1''' ('''GLYCAM1''') is a [[proteoglycan]] [[ligand]] expressed on cells of the [[high endothelial venule]]s in lymph nodes. It is able to bind to the receptor [[L-selectin]] during inflammation, acting as a homing beacon for [[leukocyte]]s expressing the receptor to enter the site of inflammation<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| | |||
==External links== | ==External links== | ||
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== References == | == References == | ||
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Revision as of 18:49, 23 May 2016
| glycosylation dependent cell adhesion molecule-1 | |
|---|---|
| Identifiers | |
| Symbol | GLYCAM1 |
| Entrez | 644076 |
| HUGO | 18023 |
| RefSeq | XM_927461 |
| UniProt | Q8IVK1 |
| Other data | |
| Locus | Chr. 12 q13.2 |
Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymph nodes. It is able to bind to the receptor L-selectin during inflammation, acting as a homing beacon for leukocytes expressing the receptor to enter the site of inflammation.[1] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[citation needed] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[2]
External links
- GlyCAM-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.Template:Pn
- ↑ Dowbenko, D; Kikuta, A; Fennie, C; Gillett, N; Lasky, L A (1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". Journal of Clinical Investigation. 92 (2): 952–60. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.
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