Focal segmental glomerulosclerosis causes: Difference between revisions
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**Lupus nephritis | **Lupus nephritis | ||
**Pauci-immune focal necrotizing and crescentic glomerulonephritis | **Pauci-immune focal necrotizing and crescentic glomerulonephritis | ||
*Alport's syndrome (hereditary nephritis) | |||
*Membranous nephropathy | |||
*Thrombotic microangiopathy | |||
==References== | ==References== | ||
Revision as of 23:57, 3 December 2013
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Focal segmental glomerulosclerosis Microchapters |
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Differentiating Focal segmental glomerulosclerosis from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief:’’’ Cafer Zorkun, M.D., Ph.D. [2]
Overview
Causes
According to D'Agati and colleagues[1], FSGS may be primary of secondary. Primary FSGS is defined as idiopathic FSGS, whereas secondary FSGS is defined as FSGS other etiologies.[1] The following list shows all the causes of FSGS[2]:
Primary (Idiopathic) FSGS
Secondary FSGS
Familial
- Mutations in alpha actinin 4
- Mutations in NPHS1 (nephrin)
- Mutations in NPHS2 (podocin)
- Mutations in WT-1
- Mutations in TRPC6
- Mutations in SCARB2 (LIMP2)
- Mutations in INF2 (formin)
- Mutations in CD2-associated protein
- Mitochondrial cytopathies
Virus Associated
- HIV
- Parvovirus B19
- CMV
Medication
- Heroin
- Interferon-alpha
- Lithium
- Pamidronate/aledronate
- Anabolic steroids
Adaptive Structural-Functional Responses
Reduced Kidney Size
- Oligomeganephronia
- Unilateral kidney agenesis
- Kidney dysplasia
- Cortical necrosis
- Reflux nephropathy
- Surgical kidney ablation
- Chronic allograft nephropathy
- Any advanced kidney disease with reduction in functioning nephrons
Initially Normal Kidney Mass
- Diabetes mellitus
- Hypertension
- Obesity
- Cyanotic congenital heart disease
- Sickle cell anemia
Malignancy
- Lymphoma
Nonspecific Pattern of FSGS Caused by Kidney Scarring in Glomerular Disease
- Focal proliferative glomerulonephritis
- IgA nephropathy
- Lupus nephritis
- Pauci-immune focal necrotizing and crescentic glomerulonephritis
- Alport's syndrome (hereditary nephritis)
- Membranous nephropathy
- Thrombotic microangiopathy
References
- ↑ 1.0 1.1 D'Agati V (2003). "Pathologic classification of focal segmental glomerulosclerosis". Semin Nephrol. 23 (2): 117–34. doi:10.1053/snep.2003.50012. PMID 12704572.
- ↑ Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH; et al. (2013). "KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis". Am J Kidney Dis. 62 (3): 403–41. doi:10.1053/j.ajkd.2013.06.002. PMID 23871408.