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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Fas-activated serine/threonine kinase''' is an [[enzyme]] that in humans is encoded by the ''FASTK'' [[gene]].<ref name="pmid7544399">{{cite journal | vauthors = Tian Q, Taupin J, Elledge S, Robertson M, Anderson P | title = Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis | journal = J Exp Med | volume = 182 | issue = 3 | pages = 865–74 |date=Sep 1995 | pmid = 7544399 | pmc = 2192163 | doi =10.1084/jem.182.3.865 }}</ref><ref name="pmid15572676">{{cite journal | vauthors = Li W, Simarro M, Kedersha N, Anderson P | title = FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression | journal = Mol Cell Biol | volume = 24 | issue = 24 | pages = 10718–32 |date=Dec 2004 | pmid = 15572676 | pmc = 533970 | doi = 10.1128/MCB.24.24.10718-10732.2004 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FASTK Fas-activated serine/threonine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10922| accessdate = }}</ref>
| image =
| image_source = 
| PDB =
| Name = Fas-activated serine/threonine kinase
| HGNCid = 24676
| Symbol = FASTK
| AltSymbols =; FAST
| OMIM = 606965
| ECnumber =
| Homologene = 4884
| MGIid = 1913837
| GeneAtlas_image1 = PBB_GE_FASTK_214114_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_FASTK_202676_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_FASTK_210975_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10922
    | Hs_Ensembl = ENSG00000164896
    | Hs_RefseqProtein = NP_006703
    | Hs_RefseqmRNA = NM_006712
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 150404641
    | Hs_GenLoc_end = 150408884
    | Hs_Uniprot = Q14296
    | Mm_EntrezGene = 66587
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_982275
    | Mm_RefseqProtein = XP_987369
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Fas-activated serine/threonine kinase''', also known as '''FASTK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FASTK Fas-activated serine/threonine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10922| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.<ref name="entrez">{{cite web | title = Entrez Gene: FASTK Fas-activated serine/threonine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10922| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the serine/threonine [[protein kinase]] family. This kinase was shown to be activated rapidly during Fas-mediated [[apoptosis]] in [[Jurkat cells]]. In response to [[Fas receptor]] ligation, it [[Phosphorylation|phosphorylates]] the apoptosis-promoting nuclear RNA-binding protein [[TIA1]]. The encoded protein is a strong inducer of [[lymphocyte]] apoptosis. Two [[transcript variant]]s encoding different [[isoform]]s have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Tian Q, Taupin J, Elledge S, ''et al.'' |title=Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. |journal=J. Exp. Med. |volume=182 |issue= 3 |pages= 865-74 |year= 1995 |pmid= 7544399 |doi=  }}
*{{cite journal  | vauthors=Auffray C, Behar G, Bois F |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi=  |display-authors=etal}}
*{{cite journal  | author=Auffray C, Behar G, Bois F, ''et al.'' |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=318 |issue= 2 |pages= 263-72 |year= 1995 |pmid= 7757816 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Scherer SW, Cheung J, MacDonald JR |title=Human chromosome 7: DNA sequence and biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |display-authors=etal}}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Li W, Kedersha N, Chen S |title=FAST is a BCL-X(L)-associated mitochondrial protein |journal=Biochem. Biophys. Res. Commun. |volume=318 |issue= 1 |pages= 95–102 |year= 2004 |pmid= 15110758 |doi= 10.1016/j.bbrc.2004.03.188 |display-authors=etal}}
*{{cite journal  | author=Li W, Kedersha N, Chen S, ''et al.'' |title=FAST is a BCL-X(L)-associated mitochondrial protein. |journal=Biochem. Biophys. Res. Commun. |volume=318 |issue= 1 |pages= 95-102 |year= 2004 |pmid= 15110758 |doi= 10.1016/j.bbrc.2004.03.188 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal | author=Li W, Simarro M, Kedersha N, Anderson P |title=FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10718-32 |year= 2004 |pmid= 15572676 |doi= 10.1128/MCB.24.24.10718-10732.2004 }}
*{{cite journal  | vauthors=Oh JH, Yang JO, Hahn Y |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Izquierdo JM, Valcárcel J |title=Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing |journal=J. Biol. Chem. |volume=282 |issue= 3 |pages= 1539–43 |year= 2007 |pmid= 17135269 |doi= 10.1074/jbc.C600198200 }}
*{{cite journal  | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal  | vauthors=Simarro M, Mauger D, Rhee K |title=Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 27 |pages= 11370–5 |year= 2007 |pmid= 17592127 |doi= 10.1073/pnas.0704964104 | pmc=2040905 |display-authors=etal}}
*{{cite journal  | author=Izquierdo JM, Valcárcel J |title=Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. |journal=J. Biol. Chem. |volume=282 |issue= 3 |pages= 1539-43 |year= 2007 |pmid= 17135269 |doi= 10.1074/jbc.C600198200 }}
*{{cite journal  | author=Simarro M, Mauger D, Rhee K, ''et al.'' |title=Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 27 |pages= 11370-5 |year= 2007 |pmid= 17592127 |doi= 10.1073/pnas.0704964104 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]
 
 
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Revision as of 01:42, 28 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.[1][2][3]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates the apoptosis-promoting nuclear RNA-binding protein TIA1. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.[3]

References

  1. ↑ Tian Q, Taupin J, Elledge S, Robertson M, Anderson P (Sep 1995). "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis". J Exp Med. 182 (3): 865–74. doi:10.1084/jem.182.3.865. PMC 2192163. PMID 7544399.
  2. ↑ Li W, Simarro M, Kedersha N, Anderson P (Dec 2004). "FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression". Mol Cell Biol. 24 (24): 10718–32. doi:10.1128/MCB.24.24.10718-10732.2004. PMC 533970. PMID 15572676.
  3. ↑ 3.0 3.1 "Entrez Gene: FASTK Fas-activated serine/threonine kinase".

Further reading


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