Difference between revisions of "Extranodal NK-T-cell lymphoma historical perspective"

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== Overview ==
  
First known case of Natural-Killer-cell lymphoma was a 19-years old man,with a tumor affecting nasal cavity. It was diagnosed as "Granuloma Gangraenescens" which was considered as unclassified sarcoma.The diagnosis was confirmed by pathology as Wegner's Granulomatosis was ruled out.
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== Historical Perspective ==
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First known case of Natural-Killer-cell lymphoma was a 19-years old man, with a tumor affecting nasal cavity. It was diagnosed as "Granuloma Gangraenescens" which was considered as unclassified sarcoma. The diagnosis was confirmed by pathology as Wegner's Granulomatosis was ruled out.
  
 
33 years later,in 1998, the patient had a relapse with skin lesions which progressed with nasal involvement in 2002, and the final mortal relapse was in 2003 with leukemic disease. Reanalysis of stored slides of 1965 revealed an immunophenotype typical of NK cell which was similar to those found in 1998 skin lesions, 2002 nasal tissue and 2003 blood.Biopsy specimen collected in 1998 and 2002 contained EBV virus encoded RNA transcripts and then diagnosed as a Natural-killer-cell lymphoma.<ref name="pmid14736941">{{cite journal| author=Schrader C, Janssen D, Kneba M, Lennert K| title=A 38-year history of natural-killer-cell lymphoma. | journal=N Engl J Med | year= 2004 | volume= 350 | issue= 4 | pages= 418-9 | pmid=14736941 | doi=10.1056/NEJM200401223500423 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14736941  }} </ref>  
 
33 years later,in 1998, the patient had a relapse with skin lesions which progressed with nasal involvement in 2002, and the final mortal relapse was in 2003 with leukemic disease. Reanalysis of stored slides of 1965 revealed an immunophenotype typical of NK cell which was similar to those found in 1998 skin lesions, 2002 nasal tissue and 2003 blood.Biopsy specimen collected in 1998 and 2002 contained EBV virus encoded RNA transcripts and then diagnosed as a Natural-killer-cell lymphoma.<ref name="pmid14736941">{{cite journal| author=Schrader C, Janssen D, Kneba M, Lennert K| title=A 38-year history of natural-killer-cell lymphoma. | journal=N Engl J Med | year= 2004 | volume= 350 | issue= 4 | pages= 418-9 | pmid=14736941 | doi=10.1056/NEJM200401223500423 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14736941  }} </ref>  

Revision as of 13:01, 16 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]

Overview

Historical Perspective

First known case of Natural-Killer-cell lymphoma was a 19-years old man, with a tumor affecting nasal cavity. It was diagnosed as "Granuloma Gangraenescens" which was considered as unclassified sarcoma. The diagnosis was confirmed by pathology as Wegner's Granulomatosis was ruled out.

33 years later,in 1998, the patient had a relapse with skin lesions which progressed with nasal involvement in 2002, and the final mortal relapse was in 2003 with leukemic disease. Reanalysis of stored slides of 1965 revealed an immunophenotype typical of NK cell which was similar to those found in 1998 skin lesions, 2002 nasal tissue and 2003 blood.Biopsy specimen collected in 1998 and 2002 contained EBV virus encoded RNA transcripts and then diagnosed as a Natural-killer-cell lymphoma.[1]

References

  1. Schrader C, Janssen D, Kneba M, Lennert K (2004). "A 38-year history of natural-killer-cell lymphoma". N Engl J Med. 350 (4): 418–9. doi:10.1056/NEJM200401223500423. PMID 14736941.

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