Extranodal NK-T-cell lymphoma classification

Jump to navigation Jump to search

Extranodal NK-T-cell lymphoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Extranodal NK-T-cell lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Xray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Extranodal NK-T-cell lymphoma classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Extranodal NK-T-cell lymphoma classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Extranodal NK-T-cell lymphoma classification

CDC on Extranodal NK-T-cell lymphoma classification

Extranodal NK-T-cell lymphoma classification in the news

Blogs on Extranodal NK-T-cell lymphoma classification

Risk calculators and risk factors for Extranodal NK-T-cell lymphoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]

Overview

In contrast with B-cell lymphoma, the classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar immuno-phenotype. Because of such matters, clinical features became handier for classification and somehow even more important than the precise cell of origin. since the majority of cytotoxic T-cell and NK cell lymphomas are located out of lymph nodes, the gene expressing cytotoxic molecules may predispose to apoptosis by tumor cells and by standard cells.Three major categories of extranodal T/NK cell tumors include: Extranodal NK/T-cell lymphoma, nasal type lymphoma, Extranodal NK/T-cell lymphoma, enteropathy type lymphoma, Extranodal NK/T-cell lymphoma, subcutaneous panniculitis-like, Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes:, NK cell-derived neoplasms, namely, aggressive NK cell leukemia, Extranodal NK/T-cell lymphoma, nasal type, Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into: Extranodal NK-T-cell lymphoma, nasal type, Extranodal NK-T-cell lymphoma, extra nasal type


Classification

  • In contrast with B-cell lymphoma, the classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar immuno-phenotype. Because of such matter, clinical features became handier for classification and somehow even more important than the precise cell of origin.[1][2]
Extranodal NK-T-cell lymphoma classification
Name Description
Extranodal NK-T-cell lymphoma, nasal type
Extranodal NK-T-cell lymphoma, extra nasal type
  • Can affect the:

Natural Killer cell neoplasms are classified by the world health organization (WHO) into:

  • NK/T-cell lymphoma, nasal type (NKTCL) [5]
  • Aggressive NK-cell leukemia (ANKCL)
  • Chronic lymphoproliferative disorders of NK-cell

References

  1. 1.0 1.1 Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016
  2. Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016,
  3. Jaffe ES, Krenacs L, Raffeld M (2003). "Classification of cytotoxic T-cell and natural killer cell lymphomas". Semin Hematol. 40 (3): 175–84. PMID 12876666.
  4. Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 18, 2016
  5. Lima M (2013). "Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis". Orphanet J Rare Dis. 8: 95. doi:10.1186/1750-1172-8-95. PMC 3770456. PMID 23816348.


Template:WikiDoc Sources