Extranodal NK-T-cell lymphoma differential diagnosis: Difference between revisions

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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center"|[[NK cell leukemia]]
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center"|[[NK cell leukemia]]
|style="padding: 5px 5px; background: #F5F5F5;" |CD16+
|style="padding: 5px 5px; background: #F5F5F5; align="center" |CD16+
|style="padding: 5px 5px; background: #F5F5F5;" | +
|style="padding: 5px 5px; background: #F5F5F5; align="center" |+
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center"|[[Lymphomatoid granulomatosis]]
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center"|[[Lymphomatoid granulomatosis]]
|CD20+
|style="padding: 5px 5px; background: #F5F5F5; align="center" |CD20+
| +
|style="padding: 5px 5px; background: #F5F5F5; align="center" |+
|-
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|[[Diffuse large B cell lymphoma|EBV-positive diffuse large B cell lymphoma, NOS]]  
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center"|[[Diffuse large B cell lymphoma|EBV-positive diffuse large B cell lymphoma, NOS]]  
|CD20+ & CD76+
|style="padding: 5px 5px; background: #F5F5F5; align="center" |CD20+ & CD76+
| +
|style="padding: 5px 5px; background: #F5F5F5; align="center" |+
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|[[Peripheral T cell lymphoma|Peripheral T cell lymphoma, unspecified]]  
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center"|[[Peripheral T cell lymphoma|Peripheral T cell lymphoma, unspecified]]  
|CD3+ & CD56-
|style="padding: 5px 5px; background: #F5F5F5; align="center" |CD3+ & CD56-
| -
|style="padding: 5px 5px; background: #F5F5F5; align="center" |-
|-
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|[[Anaplastic large cell lymphoma, ALK positive|Anaplastic large cell lymphoma]]
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center"|[[Anaplastic large cell lymphoma, ALK positive|Anaplastic large cell lymphoma]]
|CD30+
|style="padding: 5px 5px; background: #F5F5F5; align="center" |CD30+
| -
|style="padding: 5px 5px; background: #F5F5F5; align="center" |-
|-
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|[[Hepatosplenic T cell lymphoma]]  
|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center"|[[Hepatosplenic T cell lymphoma]]  
|CD2+ & CD7+&CD3+
|style="padding: 5px 5px; background: #F5F5F5; align="center" |CD2+ & CD7+&CD3+
| -
|style="padding: 5px 5px; background: #F5F5F5; align="center" |-
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Revision as of 15:53, 26 August 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

Extranodal NK-T-cell lymphoma must be differentiated from other diseases such as NK cell lukemia, lymphomatoid granulomatosis, EBV-positive diffuse large B cell lymphoma, NOS, anaplastic large cell lymphoma, non specific inflammatory process, enteropathy associated T cell lymphoma, peripheral T cell lymphoma, hepatosplenic T cell lymphoma

Extranodal NK/T-cell lymphoma, nasal type must be diffrentiated from Wegner's granulomatosis, Polymorphic reticulosis, and Midline malignant lymphoma

Differential Diagnosis

Extranodal NK t-cell must be differentiated with other NK and T cell hematologic malignancies and EBV-associated T cell or NK cell lymphoprolifrative disorders.[1]

Extranodal NK-T-cell lymphoma must be differentiated from other diseases such as:[2]

Extranodal NK-T cell lymphoma, nasal type shows aggresive lethal midline granuloma macroscopicaly so it must be differentiated from diseases such as:[4]

Differentiating extranodal NK T-cell from other hematologic malignancies by immunophenotype and EBV infection:

 Malignancies based on immunophenotype and EBV infection
Disease immunophenotype EBV
NK cell leukemia CD16+ +
Lymphomatoid granulomatosis CD20+ +
EBV-positive diffuse large B cell lymphoma, NOS CD20+ & CD76+ +
Peripheral T cell lymphoma, unspecified CD3+ & CD56- -
Anaplastic large cell lymphoma CD30+ -
Hepatosplenic T cell lymphoma CD2+ & CD7+&CD3+ -

References

  1. ↑ Karube, Kennosuke; Aoki, Ryosuke; Nomura, Yuko; Yamamoto, Kohei; Shimizu, Kay; Yoshida, Shirou; Komatani, Hideki; Sugita, Yasuo; Ohshima, Koichi (2008). "Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: Analysis of 490 cases". Pathology International. 58 (2): 89–97. doi:10.1111/j.1440-1827.2007.02195.x. ISSN 1320-5463.
  2. ↑ Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 19, 2016
  3. ↑ Kassel SH, Echevarria RA, Guzzo FP (1969). "Midline malignant reticulosis (so-called lethal midline granuloma)". Cancer. 23 (4): 920–35. doi:10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m. PMID 5818523.
  4. ↑ Kassel SH, Echevarria RA, Guzzo FP (1969). "Midline malignant reticulosis (so-called lethal midline granuloma)". Cancer. 23 (4): 920–35. doi:10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m. PMID 5818523.


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