Eosinophilic esophagitis other diagnostic studies: Difference between revisions

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==Overview==
==Overview==
[[Endoscopy|Endoscopic]] [[abnormalities]] in patients with EoE are as follows fixed [[esophageal ring]] which is corrugated, white [[Exudate|exudates]] or [[plaques]], longitudinal furrows, [[Mucous membrane|mucosal]] [[pallor]], [[diffuse]] [[esophageal]] narrowing, [[Mucous membrane|mucosal]] fragility leading to [[esophageal]] [[lacerations]] during the [[endoscopy]].
[[Endoscopy|Endoscopic]] [[abnormalities]] in patients with EoE include fixed [[esophageal ring]] which is corrugated, white [[Exudate|exudates]] or [[plaques]], longitudinal furrows, [[Mucous membrane|mucosal]] [[pallor]], [[diffuse]] [[esophageal]] narrowing, [[Mucous membrane|mucosal]] fragility leading to [[esophageal]] [[lacerations]] during the [[endoscopy]].


==Other Diagnostic Studies==
==Other Diagnostic Studies==
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**[[Mucous membrane|Mucosal]] [[pallor]]  
**[[Mucous membrane|Mucosal]] [[pallor]]  
**[[Diffuse]] [[esophageal]] narrowing  
**[[Diffuse]] [[esophageal]] narrowing  
**[[Mucosal]] fragility leading to [[esophageal]] lacerations during the endoscopy  
**[[Mucosal]] fragility leading to [[esophageal]] lacerations during the [[endoscopy]]
*However, because these [[Endoscopy|endoscopic]] features have been described in other [[esophageal]] [[disorders]], none can be considered [[pathognomonic]] for EoE.
*However, because these [[Endoscopy|endoscopic]] features have been described in other [[esophageal]] [[disorders]], none can be considered [[pathognomonic]] for EoE.


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===Biopsy===
===Biopsy===
*Characteristic features are as follows:
**> 20 eosinophils/0.24 mm2.
**[[Papillae]] are elongated
**[[Papillae]] reach into the top 1/3 of the epithelial layer
**Basal cell hyperplasia; > 3 cells thick or >15% of epithelial thickness
[[Image:Eosinophilic esophagiits path.jpg|thumb|center|150px|[[H&E]] stain of [[esophagus]] [[biopsy]] showing eosinophilic esophagitis, manifested by an infiltration of [[eosinophils]] in the [[lamina propria]]]]
[[Image:Eosinophilic esophagiits path.jpg|thumb|center|150px|[[H&E]] stain of [[esophagus]] [[biopsy]] showing eosinophilic esophagitis, manifested by an infiltration of [[eosinophils]] in the [[lamina propria]]]]



Latest revision as of 23:42, 19 December 2017

Eosinophilic Esophagitis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ajay Gade MD[2]]

Overview

Endoscopic abnormalities in patients with EoE include fixed esophageal ring which is corrugated, white exudates or plaques, longitudinal furrows, mucosal pallor, diffuse esophageal narrowing, mucosal fragility leading to esophageal lacerations during the endoscopy.

Other Diagnostic Studies

Endoscopy

Biopsy

  • Characteristic features are as follows:
    • > 20 eosinophils/0.24 mm2.
    • Papillae are elongated
    • Papillae reach into the top 1/3 of the epithelial layer
    • Basal cell hyperplasia; > 3 cells thick or >15% of epithelial thickness
H&E stain of esophagus biopsy showing eosinophilic esophagitis, manifested by an infiltration of eosinophils in the lamina propria

References

  1. "Vertical lines in distal esophageal mucosa (VLEM): a true endoscopic manifestation of esophagitis in children? - PubMed - NCBI".
  2. "Fragility of the esophageal mucosa: a pathognomonic endoscopic sign of primary eosinophilic esophagitis? - PubMed - NCBI".
  3. "Eosinophilic esophagitis: red on microscopy, white on endoscopy. - PubMed - NCBI".
  4. "The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. - PubMed - NCBI".

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