Elastofibroma

Jump to navigation Jump to search

WikiDoc Resources for Elastofibroma

Articles

Most recent articles on Elastofibroma

Most cited articles on Elastofibroma

Review articles on Elastofibroma

Articles on Elastofibroma in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Elastofibroma

Images of Elastofibroma

Photos of Elastofibroma

Podcasts & MP3s on Elastofibroma

Videos on Elastofibroma

Evidence Based Medicine

Cochrane Collaboration on Elastofibroma

Bandolier on Elastofibroma

TRIP on Elastofibroma

Clinical Trials

Ongoing Trials on Elastofibroma at Clinical Trials.gov

Trial results on Elastofibroma

Clinical Trials on Elastofibroma at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Elastofibroma

NICE Guidance on Elastofibroma

NHS PRODIGY Guidance

FDA on Elastofibroma

CDC on Elastofibroma

Books

Books on Elastofibroma

News

Elastofibroma in the news

Be alerted to news on Elastofibroma

News trends on Elastofibroma

Commentary

Blogs on Elastofibroma

Definitions

Definitions of Elastofibroma

Patient Resources / Community

Patient resources on Elastofibroma

Discussion groups on Elastofibroma

Patient Handouts on Elastofibroma

Directions to Hospitals Treating Elastofibroma

Risk calculators and risk factors for Elastofibroma

Healthcare Provider Resources

Symptoms of Elastofibroma

Causes & Risk Factors for Elastofibroma

Diagnostic studies for Elastofibroma

Treatment of Elastofibroma

Continuing Medical Education (CME)

CME Programs on Elastofibroma

International

Elastofibroma en Espanol

Elastofibroma en Francais

Business

Elastofibroma in the Marketplace

Patents on Elastofibroma

Experimental / Informatics

List of terms related to Elastofibroma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3

Overview

Historical Perspective

  • [Disease name] was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
  • In [year], [gene] mutations were first identified in the pathogenesis of [disease name].
  • In [year], the first [discovery] was developed by [scientist] to treat/diagnose [disease name].

Classification

  • [Disease name] may be classified according to [classification method] into [number] subtypes/groups:
  • [group1]
  • [group2]
  • [group3]
  • Other variants of [disease name] include [disease subtype 1], [disease subtype 2], and [disease subtype 3].

Pathophysiology

  • Elastofibroma, also called elastofibroma dorsi, is an ill-defined fibroelastic tumor-like condition made up of enlarged and irregular elastic fibers. [1] [2]
  • The genetic mutation in has been associated alterations of short arm of chromosome 1 with the development of elastofibroma.
  • On gross pathology, ill defined, nonencapsulated, rubbery, and firm, white lesion with interspersed fat are characteristic findings of elastofibroma .
  • On microscopic histopathological analysis, heavy dense bands of collagenous tissue dissected by fat and abnormal elastic fibers are characteristic findings of elastofibroma . The elastic fibers are often quite large and are easily identified. The elastic fibers are coarse, thick, and darkly eosinophilic, often fragmented into globules, creating a "string of pearls" or "pipe cleaner" appearance. Because of degeneration, the elastic fibers will appear as globules with a serrated or "prickled" edge.

Causes

  • Elastofibroma may be caused by either trauma, genetic mutation, or systemic enzyme defects.

Differentiating [disease name] from other Diseases

  • Elastofibroma must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:

Epidemiology and Demographics

  • Elastoblastoma is a very rare disease.

Age

  • Elastofibroma is more commonly observed among patients aged more than 50 years old.

Gender

  • Females are more commonly affected with Elastofibroma than male.
  • The female to male ratio is approximately 5:1.

Race

  • Elastofibroma usually reported more in individuals of the Japanese race.

Risk Factors

  • Common risk factors in the development of [disease name] are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

  • The majority of patients with [disease name] remain asymptomatic for [duration/years].
  • Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
  • If left untreated, [#%] of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
  • Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
  • Prognosis is generally [excellent/good/poor], and the [1/5/10year mortality/survival rate] of patients with [disease name] is approximately [#%].

Diagnosis

Diagnostic Criteria

  • The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met:
  • [criterion 1]
  • [criterion 2]
  • [criterion 3]
  • [criterion 4]

Symptoms

  • [Disease name] is usually asymptomatic.
  • Symptoms of [disease name] may include the following:
  • [symptom 1]
  • [symptom 2]
  • [symptom 3]
  • [symptom 4]
  • [symptom 5]
  • [symptom 6]

Physical Examination

  • Patients with elastofibroma usually appear normal.
  • Physical examination may be remarkable for:
  • Slow growing, deep-seated, firm mass, often presenting bilaterally
  • Tenderness

Laboratory Findings

  • There are no specific laboratory findings associated with [disease name].
  • A [positive/negative] [test name] is diagnostic of [disease name].
  • An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of [disease name].
  • Other laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

  • On CT, elastofibroma is characterized bypoorly circumscribed, heterogeneous soft tissue mass, with a signal intensity similar to skeletal muscle.
  • On US, elastofibroma is characterized by multilayered pattern of hypoechoic linear areas of fat deposition intermixed with echogenic fibroelastic tissue.
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

  • [Disease name] may also be diagnosed using [diagnostic study name].
  • Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • There is no treatment for [disease name]; the mainstay of therapy is supportive care.
  • The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
  • [Medical therapy 1] acts by [mechanism of action1].
  • Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

  • Surgery is the mainstay of therapy for [disease name].
  • [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of [disease name].
  • [Surgical procedure] can only be performed for patients with [disease stage] [disease name].

Prevention

  • There are no primary preventive measures available for [disease name].
  • Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
  • Once diagnosed and successfully treated, patients with [disease name] are followedup every [duration]. Followup testing includes [test 1], [test 2], and [test 3].

References

  1. Chandrasekar, C. R.; Grimer, R. J.; Carter, S. R.; Tillman, R. M.; Abudu, A.; Davies, A. M.; Sumathi, V. P. (2008). "Elastofibroma Dorsi: An Uncommon Benign Pseudotumour". Sarcoma. 2008: 1. doi:10.1155/2008/756565. PMC 2276598. PMID 18382611.
  2. Briccoli, A.; Casadei, R.; Di Renzo, M.; Favale, L.; Bacchini, P.; Bertoni, F. (2000). "Elastofibroma dorsi". Surgery today. 30 (2): 147–152. doi:10.1007/pl00010063. PMID 10664338.